BACKGROUND: Pre-eclampsia is a common complication of pregnancy and is a major cause of fetal-maternal mortality and morbidity. Despite a number of plausible mechanisms by which air pollutants might contribute to this process, few studies have investigated the association between pre-eclampsia and traffic emissions, a major contributor to air pollution in urban areas. OBJECTIVE: The authors investigated the association between traffic-related air pollution and risk of pre-eclampsia in a maternal population in the urban centre of Perth, Western Australia. METHOD: The authors estimated maternal residential exposure to a marker for traffic-related air pollution (nitrogen dioxide, NO(2)) during pregnancy for 23 452 births using temporally adjusted land-use regression. Logistic regression was used to investigate associations with pre-eclampsia. RESULTS: Each IQR increase in levels of traffic-related air pollution in whole pregnancy and third trimester was associated with a 12% (1%-25%) and 30% (7%-58%) increased risk of pre-eclampsia, respectively. The largest effect sizes were observed for women aged younger than 20 years or 40 years or older, aboriginal women and women with pre-existing and gestational diabetes, for whom an IQR increase in traffic-related air pollution in whole pregnancy was associated with a 34% (5%-72%), 35% (0%-82%) and 53% (7%-219%) increase in risk of pre-eclampsia, respectively. CONCLUSIONS: Elevated exposure to traffic-related air pollution in pregnancy was associated with increased risk of pre-eclampsia. Effect sizes were highest for elevated exposures in third trimester and among younger and older women, aboriginal women and women with diabetes.
BACKGROUND: Pre-eclampsia is a common complication of pregnancy and is a major cause of fetal-maternal mortality and morbidity. Despite a number of plausible mechanisms by which air pollutants might contribute to this process, few studies have investigated the association between pre-eclampsia and traffic emissions, a major contributor to air pollution in urban areas. OBJECTIVE: The authors investigated the association between traffic-related air pollution and risk of pre-eclampsia in a maternal population in the urban centre of Perth, Western Australia. METHOD: The authors estimated maternal residential exposure to a marker for traffic-related air pollution (nitrogen dioxide, NO(2)) during pregnancy for 23 452 births using temporally adjusted land-use regression. Logistic regression was used to investigate associations with pre-eclampsia. RESULTS: Each IQR increase in levels of traffic-related air pollution in whole pregnancy and third trimester was associated with a 12% (1%-25%) and 30% (7%-58%) increased risk of pre-eclampsia, respectively. The largest effect sizes were observed for women aged younger than 20 years or 40 years or older, aboriginal women and women with pre-existing and gestational diabetes, for whom an IQR increase in traffic-related air pollution in whole pregnancy was associated with a 34% (5%-72%), 35% (0%-82%) and 53% (7%-219%) increase in risk of pre-eclampsia, respectively. CONCLUSIONS: Elevated exposure to traffic-related air pollution in pregnancy was associated with increased risk of pre-eclampsia. Effect sizes were highest for elevated exposures in third trimester and among younger and older women, aboriginal women and women with diabetes.
Authors: Patricia D Koman; Kelly A Hogan; Natalie Sampson; Rebecca Mandell; Chris M Coombe; Myra M Tetteh; Yolanda R Hill-Ashford; Donele Wilkins; Marya G Zlatnik; Rita Loch-Caruso; Amy J Schulz; Tracey J Woodruff Journal: World Med Health Policy Date: 2018-03-12
Authors: Rong Yang; Dan Luo; Yi-Ming Zhang; Ke Hu; Zheng-Min Qian; Li-Qin Hu; Long-Jiao Shen; Hong Xian; Juliet Iwelunmor; Su-Rong Mei Journal: Curr Med Sci Date: 2019-12-16
Authors: David A Savitz; Beth Elston; Jennifer F Bobb; Jane E Clougherty; Francesca Dominici; Kazuhiko Ito; Sarah Johnson; Tara McAlexander; Zev Ross; Jessie L C Shmool; Thomas D Matte; Gregory A Wellenius Journal: Epidemiology Date: 2015-09 Impact factor: 4.822
Authors: Natalie M Johnson; Aline Rodrigues Hoffmann; Jonathan C Behlen; Carmen Lau; Drew Pendleton; Navada Harvey; Ross Shore; Yixin Li; Jingshu Chen; Yanan Tian; Renyi Zhang Journal: Environ Health Prev Med Date: 2021-07-12 Impact factor: 3.674