| Literature DB >> 22865621 |
Thomas Courant1, Valérie Gaëlle Roullin, Cyril Cadiou, Maïté Callewaert, Marie Christine Andry, Christophe Portefaix, Christine Hoeffel, Marie Christine de Goltstein, Marc Port, Sophie Laurent, Luce Vander Elst, Robert Muller, Michaël Molinari, Françoise Chuburu.
Abstract
Do not tumble dry: Gadolinium-DOTA encapsulated into polysaccharide nanoparticles (GdDOTA NPs) exhibited high relaxivity (r(1) =101.7 s(-1) mM(-1) per Gd(3+) ion at 37 °C and 20 MHz). This high relaxation rate is due to efficient Gd loading, reduced tumbling of the Gd complex, and the hydrogel nature of the nanoparticles. The efficacy of the nanoparticles as a T(1)/T(2) dual-mode contrast agent was studied in C6 cells.Entities:
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Year: 2012 PMID： 22865621 DOI： 10.1002/anie.201203190
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336