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Literature DB >> 24516291

pH-Responsive Theranostic Polymer-Caged Nanobins (PCNs): Enhanced Cytotoxicity and T₁ MRI Contrast by Her2-Targeting.

Bong Jin Hong¹, Elden P Swindell², Keith W Macrenaris¹, Patrick L Hankins¹, Anthony J Chipre¹, Daniel J Mastarone¹, Richard W Ahn¹, Thomas J Meade¹, Thomas V O'Halloran¹, Sonbinh T Nguyen¹.

Abstract

A PCN theranostic platform comprises a doxorubicin (DXR)-loaded liposomal core and an acid-sensitive polymer shell that is functionalized with Herceptin and GdIII-based MRI contrast agents. In vitro testing reveals a 14-fold increase in DXR-based cytotoxicity versus a non-targeted analogue and an 120-fold improvement in cellular GdIII-uptake in comparison with clinically approved DOTA-GdIII, leading to significant T1 MRI contrast enhancement.

Entities: CellLine Chemical Disease Gene Species

Keywords: cancer targeting; drug delivery; magnetic resonance imaging; pH-responsive drug release; theranostics

Year: 2013 PMID： 24516291 PMCID： PMC3916701 DOI： 10.1002/ppsc.201300158

Source DB: PubMed Journal: Part Part Syst Charact ISSN： 0934-0866 Impact factor: 3.310

40 in total

1. Multifunctional magneto-polymeric nanohybrids for targeted detection and synergistic therapeutic effects on breast cancer.

Authors: Jaemoon Yang; Choong-Hwan Lee; Hyun-Ju Ko; Jin-Suck Suh; Ho-Geun Yoon; Kwangyeol Lee; Yong-Min Huh; Seungjoo Haam
Journal: Angew Chem Int Ed Engl Date: 2007 Impact factor: 15.336

2. pH-triggered drug-releasing magnetic nanoparticles for cancer therapy guided by molecular imaging by MRI.

Authors: Eun-Kyung Lim; Yong-Min Huh; Jaemoon Yang; Kwangyeol Lee; Jin-Suck Suh; Seungjoo Haam
Journal: Adv Mater Date: 2011-04-14 Impact factor: 30.849

Review 3. Sensors and regulators of intracellular pH.

Authors: Joseph R Casey; Sergio Grinstein; John Orlowski
Journal: Nat Rev Mol Cell Biol Date: 2009-12-09 Impact factor: 94.444

4. Trastuzumab emtansine for HER2-positive advanced breast cancer.

Authors: Sunil Verma; David Miles; Luca Gianni; Ian E Krop; Manfred Welslau; José Baselga; Mark Pegram; Do-Youn Oh; Véronique Diéras; Ellie Guardino; Liang Fang; Michael W Lu; Steven Olsen; Kim Blackwell
Journal: N Engl J Med Date: 2012-10-01 Impact factor: 91.245

Review 5. Nanoparticle-based theranostic agents.

Authors: Jin Xie; Seulki Lee; Xiaoyuan Chen
Journal: Adv Drug Deliv Rev Date: 2010-08-04 Impact factor: 15.470

6. Acid pH in tumors and its potential for therapeutic exploitation.

Authors: I F Tannock; D Rotin
Journal: Cancer Res Date: 1989-08-15 Impact factor: 12.701

7. Synthesis and In vitro activity of ROMP-based polymer nanoparticles.

Authors: Deedee Smith; Sandra H Clark; Paul A Bertin; Bernard L Mirkin; Sonbinh T Nguyen
Journal: J Mater Chem Date: 2009-04-21

8. Hydrogels incorporating GdDOTA: towards highly efficient dual T1/T2 MRI contrast agents.

Authors: Thomas Courant; Valérie Gaëlle Roullin; Cyril Cadiou; Maïté Callewaert; Marie Christine Andry; Christophe Portefaix; Christine Hoeffel; Marie Christine de Goltstein; Marc Port; Sophie Laurent; Luce Vander Elst; Robert Muller; Michaël Molinari; Françoise Chuburu
Journal: Angew Chem Int Ed Engl Date: 2012-08-02 Impact factor: 15.336

pH-Responsive Theranostic Polymer-Caged Nanobins (PCNs): Enhanced Cytotoxicity and T₁ MRI Contrast by Her2-Targeting.

1. Multifunctional magneto-polymeric nanohybrids for targeted detection and synergistic therapeutic effects on breast cancer.

2. pH-triggered drug-releasing magnetic nanoparticles for cancer therapy guided by molecular imaging by MRI.

Review 3. Sensors and regulators of intracellular pH.

4. Trastuzumab emtansine for HER2-positive advanced breast cancer.

Review 5. Nanoparticle-based theranostic agents.

6. Acid pH in tumors and its potential for therapeutic exploitation.

7. Synthesis and In vitro activity of ROMP-based polymer nanoparticles.

8. Hydrogels incorporating GdDOTA: towards highly efficient dual T1/T2 MRI contrast agents.

9. "Clickable" polymer-caged nanobins as a modular drug delivery platform.

10. Multimodality imaging in vivo for preclinical assessment of tumor-targeted doxorubicin nanoparticles.

1. Smart Nanoscale Drug Delivery Platforms from Stimuli-Responsive Polymers and Liposomes.

2. Highly Stable, Ultrasmall Polymer-Grafted Nanobins (usPGNs) with Stimuli-Responsive Capability.

3. Graphene oxide enhances cellular delivery of hydrophilic small molecules by co-incubation.

Review 4. Current advances in polymer-based nanotheranostics for cancer treatment and diagnosis.

Review 5. Versatile Nanosystem-Based Cancer Theranostics: Design Inspiration and Predetermined Routing.