Literature DB >> 22853708

Automated synthesis of a library of triazolated 1,2,5-thiadiazepane 1,1-dioxides via a double aza-Michael strategy.

Qin Zang, Salim Javed, David Hill, Farman Ullah, Danse Bi, Patrick Porubsky, Benjamin Neuenswander, Gerald H Lushington, Conrad Santini, Michael G Organ, Paul R Hanson.   

Abstract

The construction of a 96-member library of triazolated 1,2,5-thiadiazepane 1,1-dioxides was performed on a Chemspeed Accelerator (SLT-100) automated parallel synthesis platform, culminating in the successful preparation of 94 out of 96 possible products. The key step, a one-pot, sequential elimination, double-aza-Michael reaction, and [3 + 2] Huisgen cycloaddition pathway has been automated and utilized in the production of two sets of triazolated sultam products.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22853708      PMCID： PMC3656823          DOI： 10.1021/co300049u

Source DB:  PubMed          Journal:  ACS Comb Sci        ISSN： 2156-8944            Impact factor:   3.784


  15 in total

1.  Drug discovery: a historical perspective.

Authors:  J Drews
Journal:  Science       Date:  2000-03-17       Impact factor: 47.728

2.  A chicken in every pot, thanks to sulfonamide drugs.

Authors:  M A Navia
Journal:  Science       Date:  2000-06-23       Impact factor: 47.728

3.  Automated 'X-Y' robot for peptide synthesis with microwave heating: application to difficult peptide sequences and protein domains.

Authors:  Leila Malik; A Pernille Tofteng; Søren L Pedersen; Kasper K Sørensen; Knud J Jensen
Journal:  J Pept Sci       Date:  2010-09       Impact factor: 1.905

4.  SynCar: an approach to automated synthesis.

Authors:  Angelika Weber; Erich von Roedern; Hans Ulrich Stilz
Journal:  J Comb Chem       Date:  2005 Mar-Apr

5.  A formal total synthesis of taxol aided by an automated synthesizer.

Authors:  Takayuki Doi; Shinichiro Fuse; Shigeru Miyamoto; Kazuoki Nakai; Daisuke Sasuga; Takashi Takahashi
Journal:  Chem Asian J       Date:  2006-09-18

Review 6.  Automated oligosaccharide synthesis.

Authors:  Peter H Seeberger
Journal:  Chem Soc Rev       Date:  2007-08-20       Impact factor: 54.564

7.  Total synthesis of spiruchostatin B aided by an automated synthesizer.

Authors:  Shinichiro Fuse; Kumiko Okada; Yusuke Iijima; Asami Munakata; Kazuhiro Machida; Takashi Takahashi; Motoki Takagi; Kazuo Shin-ya; Takayuki Doi
Journal:  Org Biomol Chem       Date:  2011-03-29       Impact factor: 3.876

8.  Application of a Double Aza-Michael Reaction in a 'Click, Click, Cy-Click' Strategy: From Bench to Flow.

Authors:  Qin Zang; Salim Javed; Farman Ullah; Aihua Zhou; Christopher A Knudtson; Danse Bi; Fatima Z Basha; Michael G Organ; Paul R Hanson
Journal:  Synthesis (Stuttg)       Date:  2011-09-01       Impact factor: 3.157

9.  Automated synthesis of a 184-member library of thiadiazepan-1,1-dioxide-4-ones.

Authors:  Erik Fenster; Toby R Long; Qin Zang; David Hill; Benjamin Neuenswander; Gerald H Lushington; Aihua Zhou; Conrad Santini; Paul R Hanson
Journal:  ACS Comb Sci       Date:  2011-02-10       Impact factor: 3.784

10.  A highly automated, polymer-assisted strategy for the preparation of 2-alkylthiobenzimidazoles and N,N'-dialkylbenzimidazolin-2-ones.

Authors:  Emma Vickerstaffe; Brian H Warrington; Mark Ladlow; Steven V Ley
Journal:  J Comb Chem       Date:  2005 May-Jun
View more
  3 in total

1.  A summary of seven- and eight-membered ring sultam syntheses via three Michael addition reactions.

Authors:  Ben Niu; Ping Xie; Min Wang; Yanjie Wang; Wannian Zhao; Charles U Pittman; Aihua Zhou
Journal:  Mol Divers       Date:  2015-04-03       Impact factor: 2.943

2.  Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 1: A One-Pot Sulfonylation/Thia-Michael Protocol.

Authors:  Qin Zang; Aihua Zhou; Salim Javed; Pradip K Maity; Chris A Knudtson; Danse Bi; Jared J Hastings; Fatima Z Basha; Paul R Hanson
Journal:  Heterocycles       Date:  2012-12-31       Impact factor: 0.831

Review 3.  Machine-Assisted Organic Synthesis.

Authors:  Steven V Ley; Daniel E Fitzpatrick; Rebecca M Myers; Claudio Battilocchio; Richard J Ingham
Journal:  Angew Chem Int Ed Engl       Date:  2015-07-16       Impact factor: 15.336
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.