| Literature DB >> 21445425 |
Shinichiro Fuse1, Kumiko Okada, Yusuke Iijima, Asami Munakata, Kazuhiro Machida, Takashi Takahashi, Motoki Takagi, Kazuo Shin-ya, Takayuki Doi.
Abstract
The total synthesis of a natural product HDAC inhibitor, spiruchostatin B, was successfully achieved. A 5-step synthesis that included an asymmetric aldol reaction was carried out in an automated synthesizer to provide an (E)-(S)-3-hydroxy-7-thio-4-heptenoic acid segment that is the crucial structure of cysteine-containing, depsipeptidic natural products such as spiruchostatins, FK228, FR901375, and largazole for their inhibitory activity against HDACs.Entities:
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Year: 2011 PMID： 21445425 DOI： 10.1039/c0ob01169j
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876