| Literature DB >> 17441074 |
Takayuki Doi1, Shinichiro Fuse, Shigeru Miyamoto, Kazuoki Nakai, Daisuke Sasuga, Takashi Takahashi.
Abstract
A 36-step synthesis was carried out in automated synthesizers to provide a synthetic key intermediate of taxol. A key step involved a microwave-assisted alkylation reaction to construct the ABC ring system from an AC precursor. Subsequent formation of the D ring afforded baccatin III, a well-known precursor of taxol.Entities:
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Year: 2006 PMID： 17441074 DOI： 10.1002/asia.200600156
Source DB: PubMed Journal: Chem Asian J ISSN： 1861-471X