Literature DB >> 22853191

Water-soluble poly(L-serine)s with elongated and charged side-chains: synthesis, conformations, and cell-penetrating properties.

Haoyu Tang1, Lichen Yin, Hua Lu, Jianjun Cheng.   

Abstract

Water-soluble poly(L-serine)s bearing long side-chain with terminal charge groups were synthesized via ring-opening polymerization of O-pentenyl-L-serine N-carboxyanhydride followed by thiol-ene reactions. These side-chain modified poly(L-serine)s adopt β-sheet conformation in aqueous solution with excellent stability against changes in pH and temperature. These water-soluble poly(L-serine) derivatives with charged side-chain functional groups and stable β-sheet conformations showed membrane-penetrating capabilities in different cell lines with low cytotoxicity.

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Year:  2012        PMID： 22853191      PMCID： PMC3555145          DOI： 10.1021/bm3009445

Source DB:  PubMed          Journal:  Biomacromolecules        ISSN： 1525-7797            Impact factor:   6.988


  30 in total

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Journal:  Biomacromolecules       Date:  2001       Impact factor: 6.988

5.  The thermal melting of poly-L-alanine helices in water.

Authors:  N Lotan; A Berger; E Katchalski; R T Ingwall; H A Scheraga
Journal:  Biopolymers       Date:  1966       Impact factor: 2.505

6.  Water-Soluble Polypeptides with Elongated, Charged Side Chains Adopt Ultra-Stable Helical Conformations.

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7.  Thermoresponsive polypeptides from pegylated poly-L-glutamates.

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Journal:  Biomacromolecules       Date:  2011-07-05       Impact factor: 6.988

8.  A single carboxy-terminal arginine determines the amino-terminal helix conformation of an alanine-based peptide.

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Journal:  Nat Struct Biol       Date:  1994-06

9.  Mammalian cell penetration, siRNA transfection, and DNA transfection by supercharged proteins.

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10.  Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides.

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  7 in total

Review 1.  Ionic α-helical polypeptides toward nonviral gene delivery.

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Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2014-11-06

2.  Site-Specific Drug-Releasing Polypeptide Nanocarriers Based on Dual-pH Response for Enhanced Therapeutic Efficacy against Drug-Resistant Tumors.

Authors:  Yaqiong Dong; Jun Yang; Hongmei Liu; Tianyou Wang; Suoqin Tang; Jinchao Zhang; Xin Zhang
Journal:  Theranostics       Date:  2015-04-28       Impact factor: 11.556

3.  Polypeptides with quaternary phosphonium side chains: synthesis, characterization, and cell-penetrating properties.

Authors:  Ziyuan Song; Nan Zheng; Xiaochu Ba; Lichen Yin; Rujing Zhang; Liang Ma; Jianjun Cheng
Journal:  Biomacromolecules       Date:  2014-03-17       Impact factor: 6.988

4.  Bio-inspired synthetic nanovesicles for glucose-responsive release of insulin.

Authors:  Wanyi Tai; Ran Mo; Jin Di; Vinayak Subramanian; Xiao Gu; John B Buse; Zhen Gu
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5.  Self-assembled micelles of amphiphilic poly(L-phenylalanine)-b-poly(L-serine) polypeptides for tumor-targeted delivery.

Authors:  Ziming Zhao; Yu Wang; Jin Han; Keli Wang; Dan Yang; Yihua Yang; Qian Du; Yuanjian Song; Xiaoxing Yin
Journal:  Int J Nanomedicine       Date:  2014-12-12

6.  Design and Synthesis of Helical N-Terminal L-Prolyl Oligopeptides Possessing Hydrocarbon Stapling.

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Journal:  Molecules       Date:  2020-10-13       Impact factor: 4.411

7.  X-ray Crystallographic Structure of α-Helical Peptide Stabilized by Hydrocarbon Stapling at i,i + 1 Positions.

Authors:  Yui Makura; Atsushi Ueda; Takuma Kato; Akihiro Iyoshi; Mei Higuchi; Mitsunobu Doi; Masakazu Tanaka
Journal:  Int J Mol Sci       Date:  2021-05-19       Impact factor: 5.923
  7 in total

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