| Literature DB >> 25377262 |
Rujing Zhang1, Ziyuan Song, Lichen Yin, Nan Zheng, Haoyu Tang, Hua Lu, Nathan P Gabrielson, Yao Lin, Kyung Kim, Jianjun Cheng.
Abstract
The advent of polymeric materials has significantly promoted the development and rapid growth of various technologies in biomedical applications, such as tissue engineering and controlled drug and gene delivery. Water-soluble polypeptides bearing functional side chains and adopting stable secondary structures are a new class of functional polymeric materials of potentially broad applications in medicine and biotechnology. In this article, we summarize our recent effort on the design and synthesis of the water-soluble α-helical ionic polypeptides originally developed in our laboratory and highlight their applications in cell membrane penetration and nonviral gene/small interfering RNA (siRNA) delivery.Entities:
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Year: 2014 PMID： 25377262 PMCID： PMC4545666 DOI： 10.1002/wnan.1307
Source DB: PubMed Journal: Wiley Interdiscip Rev Nanomed Nanobiotechnol ISSN： 1939-0041