Literature DB >> 2285293

Effect of food on absorption of lomefloxacin.

W D Hooper1, R G Dickinson, M J Eadie.   

Abstract

Twelve subjects participated in an open-label, single-dose, balanced three-way crossover study in which the absorptions of lomefloxacin were compared following (i) an overnight fast, (ii) a carbohydrate meal, and (iii) a high-fat meal. The time to peak concentration of lomefloxacin was delayed, but peak concentration in plasma and amount of drug absorbed were unchanged following both meals.

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Year:  1990        PMID： 2285293      PMCID： PMC171929          DOI： 10.1128/AAC.34.9.1797

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  4 in total

1.  Effect of food on enoxacin absorption.

Authors:  A A Somogyi; F Bochner; J A Keal; P E Rolan; M Smith
Journal:  Antimicrob Agents Chemother       Date:  1987-04       Impact factor: 5.191

Review 2.  Influence of food on the bioavailability of drugs.

Authors:  A Melander
Journal:  Clin Pharmacokinet       Date:  1978 Sep-Oct       Impact factor: 6.447

3.  Ofloxacin: serum and skin blister fluid pharmacokinetics in the fasting and non-fasting state.

Authors:  T Kalager; A Digranes; T Bergan; T Rolstad
Journal:  J Antimicrob Chemother       Date:  1986-06       Impact factor: 5.790

4.  Effect of standard breakfast on drug absorption and multiple-dose pharmacokinetics of ciprofloxacin.

Authors:  B Ledergerber; J D Bettex; B Joos; M Flepp; R Lüthy
Journal:  Antimicrob Agents Chemother       Date:  1985-03       Impact factor: 5.191
  4 in total
  10 in total

1.  Predicting effect of food on extent of drug absorption based on physicochemical properties.

Authors:  Chong-Hui Gu; Hua Li; Jaquan Levons; Kimberley Lentz; Rajesh B Gandhi; Krishnaswamy Raghavan; Ronald L Smith
Journal:  Pharm Res       Date:  2007-03-24       Impact factor: 4.200

Review 2.  Lomefloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Authors:  A N Wadworth; K L Goa
Journal:  Drugs       Date:  1991-12       Impact factor: 9.546

3.  Effects of milk and food on the absorption of enoxacin.

Authors:  P Lehto; K T Kivistö
Journal:  Br J Clin Pharmacol       Date:  1995-02       Impact factor: 4.335

4.  Effect of enteral feeding with ensure on oral bioavailabilities of ofloxacin and ciprofloxacin.

Authors:  B A Mueller; D G Brierton; S R Abel; L Bowman
Journal:  Antimicrob Agents Chemother       Date:  1994-09       Impact factor: 5.191

5.  Effect of food and gastric pH on the bioavailability of grepafloxacin.

Authors:  C Efthymiopoulos; S L Bramer; A Maroli
Journal:  Clin Pharmacokinet       Date:  1997       Impact factor: 6.447

Review 6.  Effects of food on clinical pharmacokinetics.

Authors:  B N Singh
Journal:  Clin Pharmacokinet       Date:  1999-09       Impact factor: 6.447

7.  Effect of a fat- and calcium-rich breakfast on pharmacokinetics of fleroxacin administered in single and multiple doses.

Authors:  J S Bertino; A N Nafziger; M Wong; L Stragand; C Puleo
Journal:  Antimicrob Agents Chemother       Date:  1994-03       Impact factor: 5.191

Review 8.  Lomefloxacin clinical pharmacokinetics.

Authors:  C D Freeman; D P Nicolau; P P Belliveau; C H Nightingale
Journal:  Clin Pharmacokinet       Date:  1993-07       Impact factor: 6.447

Review 9.  Absorption interactions with fluoroquinolones. 1995 update.

Authors:  B M Lomaestro; G R Bailie
Journal:  Drug Saf       Date:  1995-05       Impact factor: 5.606

10.  The effect of food on the bioavailability of temafloxacin. A review of 3 studies.

Authors:  G R Granneman; D Mukherjee
Journal:  Clin Pharmacokinet       Date:  1992       Impact factor: 6.447
  10 in total

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