Literature DB >> 22847956

Evaluation of flavonoid and resveratrol chemical libraries reveals abyssinone II as a promising antibacterial lead.

Dianqing Sun1, Julian G Hurdle, Robin Lee, Richard Lee, Mark Cushman, John M Pezzuto.   

Abstract

Lead on! In the course of screening flavonoid and resveratrol libraries, abyssinone II, a naturally occurring prenylated flavonoid, was found to exhibit relatively good antitubercular and antibacterial activity. Preliminary mechanistic studies revealed that abyssinone II hyperpolarizes the bacterial membrane potential and inhibits the biosynthesis of key cellular macromolecules (DNA, RNA, and protein).
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22847956      PMCID： PMC3516920          DOI： 10.1002/cmdc.201200253

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


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