Literature DB >> 24363888

Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors.

Hao Lin1, Thirunavukkarasu Annamalai2, Priyanka Bansod2, Yuk-Ching Tse-Dinh2, Dianqing Sun1.   

Abstract

Naturally occurring anziaic acid was very recently reported as a topoisomerase I inhibitor with antibacterial activity. Herein total synthesis of anziaic acid and structural analogues is described and the preliminary structure-activity relationship (SAR) has been developed based on topoisomerase inhibition and whole cell antibacterial activity.

Entities:  

Year:  2013        PMID： 24363888      PMCID： PMC3867937          DOI： 10.1039/C3MD00238A

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


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