Hao Lin1, Thirunavukkarasu Annamalai2, Priyanka Bansod2, Yuk-Ching Tse-Dinh2, Dianqing Sun1. 1. Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, HI 96720, USA. ; Tel: 1-(808)-933-2960. 2. Department of Chemistry & Biochemistry, Florida International University, 11200 SW 8 Street, Miami, FL 33199, USA.
Abstract
Naturally occurring anziaic acid was very recently reported as a topoisomerase I inhibitor with antibacterial activity. Herein total synthesis of anziaic acid and structural analogues is described and the preliminary structure-activity relationship (SAR) has been developed based on topoisomerase inhibition and whole cell antibacterial activity.
Naturally occurring n class="Chemical">anziaic acid was very recently reported as a topoisomerase I inhibitor with antibacterial activity. Herein total synthesis of anziaic acid and structural analogues is described and the preliminary structure-activity relationship (SAR) has been developed based on topoisomerase inhibition and whole cell antibacterial activity.
Authors: Li Shen; Marcus M Maddox; Sudip Adhikari; David F Bruhn; Manish Kumar; Robin E Lee; Julian G Hurdle; Richard E Lee; Dianqing Sun Journal: J Antibiot (Tokyo) Date: 2013-04-03 Impact factor: 2.649
Authors: Li Feng; Marcus M Maddox; Md Zahidul Alam; Lissa S Tsutsumi; Gagandeep Narula; David F Bruhn; Xiaoqian Wu; Shayna Sandhaus; Robin B Lee; Charles J Simmons; Yuk-Ching Tse-Dinh; Julian G Hurdle; Richard E Lee; Dianqing Sun Journal: J Med Chem Date: 2014-10-07 Impact factor: 7.446