Literature DB >> 22847273

The continuing value of twin studies in the omics era.

Jenny van Dongen1, P Eline Slagboom, Harmen H M Draisma, Nicholas G Martin, Dorret I Boomsma.   

Abstract

The classical twin study has been a powerful heuristic in biomedical, psychiatric and behavioural research for decades. Twin registries worldwide have collected biological material and longitudinal phenotypic data on tens of thousands of twins, providing a valuable resource for studying complex phenotypes and their underlying biology. In this Review, we consider the continuing value of twin studies in the current era of molecular genetic studies. We conclude that classical twin methods combined with novel technologies represent a powerful approach towards identifying and understanding the molecular pathways that underlie complex traits.

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Year:  2012        PMID： 22847273     DOI： 10.1038/nrg3243

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN： 1471-0056            Impact factor:   53.242


  144 in total

1.  A longitudinal study of epigenetic variation in twins.

Authors:  Chloe Chung Yi Wong; Avshalom Caspi; Benjamin Williams; Ian W Craig; Renate Houts; Antony Ambler; Terrie E Moffitt; Jonathan Mill
Journal:  Epigenetics       Date:  2010-08-16       Impact factor: 4.528

2.  Co-twin control and cohort analyses of body mass index and height in relation to breast, prostate, ovarian, corpus uteri, colon and rectal cancer among Swedish and Finnish twins.

Authors:  Ellen Lundqvist; Jaakko Kaprio; Pia K Verkasalo; Eero Pukkala; Markku Koskenvuo; Karin C Söderberg; Maria Feychting
Journal:  Int J Cancer       Date:  2007-08-15       Impact factor: 7.396

Review 3.  Twin studies and the heritability of MS: a conclusion.

Authors:  C H Hawkes; A J Macgregor
Journal:  Mult Scler       Date:  2009-06       Impact factor: 6.312

4.  Personal genomes: The case of the missing heritability.

Authors:  Brendan Maher
Journal:  Nature       Date:  2008-11-06       Impact factor: 49.962

5.  The eukaryotic genome as an RNA machine.

Authors:  Paulo P Amaral; Marcel E Dinger; Tim R Mercer; John S Mattick
Journal:  Science       Date:  2008-03-28       Impact factor: 47.728

6.  Variability gene effect on cholesterol at the Kidd blood group locus.

Authors:  K Berg
Journal:  Clin Genet       Date:  1988-02       Impact factor: 4.438

7.  A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes.

Authors:  Ben P Willing; Johan Dicksved; Jonas Halfvarson; Anders F Andersson; Marianna Lucio; Zongli Zheng; Gunnar Järnerot; Curt Tysk; Janet K Jansson; Lars Engstrand
Journal:  Gastroenterology       Date:  2010-10-08       Impact factor: 22.682

8.  The shared genetics of migraine and anxious depression.

Authors:  Lannie Ligthart; Dale R Nyholt; Brenda W J H Penninx; Dorret I Boomsma
Journal:  Headache       Date:  2010-11       Impact factor: 5.887

9.  Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins.

Authors:  G Kuratomi; K Iwamoto; M Bundo; I Kusumi; N Kato; N Iwata; N Ozaki; T Kato
Journal:  Mol Psychiatry       Date:  2007-05-01       Impact factor: 15.992

10.  Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans.

Authors:  Kirsi H Pietiläinen; Tomasz Róg; Tuulikki Seppänen-Laakso; Sam Virtue; Peddinti Gopalacharyulu; Jing Tang; Sergio Rodriguez-Cuenca; Arkadiusz Maciejewski; Jussi Naukkarinen; Anna-Liisa Ruskeepää; Perttu S Niemelä; Laxman Yetukuri; Chong Yew Tan; Vidya Velagapudi; Sandra Castillo; Heli Nygren; Tuulia Hyötyläinen; Aila Rissanen; Jaakko Kaprio; Hannele Yki-Järvinen; Ilpo Vattulainen; Antonio Vidal-Puig; Matej Orešič
Journal:  PLoS Biol       Date:  2011-06-07       Impact factor: 8.029
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  110 in total

Review 1.  From promises to practical strategies in epigenetic epidemiology.

Authors:  Jonathan Mill; Bastiaan T Heijmans
Journal:  Nat Rev Genet       Date:  2013-07-02       Impact factor: 53.242

2.  Genes contributing to subcortical volumes and intellectual ability implicate the thalamus.

Authors:  Marc M Bohlken; Rachel M Brouwer; René C W Mandl; Neeltje E M van Haren; Rachel G H Brans; G Caroline M van Baal; Eco J C de Geus; Dorret I Boomsma; René S Kahn; Hilleke E Hulshoff Pol
Journal:  Hum Brain Mapp       Date:  2013-09-13       Impact factor: 5.038

3.  Chronic diseases and objectively monitored physical activity profile among aged individuals - a cross-sectional twin cohort study.

Authors:  Urho M Kujala; Pekka Hautasaari; Henri Vähä-Ypyä; Katja Waller; Noora Lindgren; Paula Iso-Markku; Kauko Heikkilä; Juha Rinne; Jaakko Kaprio; Harri Sievänen
Journal:  Ann Med       Date:  2019-03-05       Impact factor: 4.709

4.  Overlapping genetic and environmental influences on nonsuicidal self-injury and suicidal ideation: different outcomes, same etiology?

Authors:  Dominique F Maciejewski; Hanneke E Creemers; Michael T Lynskey; Pamela A F Madden; Andrew C Heath; Dixie J Statham; Nicholas G Martin; Karin J H Verweij
Journal:  JAMA Psychiatry       Date:  2014-06       Impact factor: 21.596

5.  Serum microRNAs explain discordance of non-alcoholic fatty liver disease in monozygotic and dizygotic twins: a prospective study.

Authors:  Amir Zarrinpar; Shakti Gupta; Mano R Maurya; Shankar Subramaniam; Rohit Loomba
Journal:  Gut       Date:  2015-05-22       Impact factor: 23.059

Review 6.  Genetic and epigenetic trends in telomere research: a novel way in immunoepigenetics.

Authors:  Dora Melicher; Edit I Buzas; Andras Falus
Journal:  Cell Mol Life Sci       Date:  2015-07-20       Impact factor: 9.261

Review 7.  Making headway towards understanding how epigenetic mechanisms contribute to early-life effects.

Authors:  Maja Vukic; Haoyu Wu; Lucia Daxinger
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2019-04-15       Impact factor: 6.237

8.  De novo single-nucleotide and copy number variation in discordant monozygotic twins reveals disease-related genes.

Authors:  Nirmal Vadgama; Alan Pittman; Michael Simpson; Niranjanan Nirmalananthan; Robin Murray; Takeo Yoshikawa; Peter De Rijk; Elliott Rees; George Kirov; Deborah Hughes; Tomas Fitzgerald; Mark Kristiansen; Kerra Pearce; Eliza Cerveira; Qihui Zhu; Chengsheng Zhang; Charles Lee; John Hardy; Jamal Nasir
Journal:  Eur J Hum Genet       Date:  2019-03-18       Impact factor: 4.246

9.  Overweight is associated with lower resting state functional connectivity in females after eliminating genetic effects: A twin study.

Authors:  Stieneke Doornweerd; Eelco van Duinkerken; Eco J de Geus; Parniane Arbab-Zadeh; Dick J Veltman; Richard G IJzerman
Journal:  Hum Brain Mapp       Date:  2017-07-17       Impact factor: 5.038

Review 10.  The contribution of genetic and environmental factors to the duration of pregnancy.

Authors:  Timothy P York; Lindon J Eaves; Michael C Neale; Jerome F Strauss
Journal:  Am J Obstet Gynecol       Date:  2013-10-02       Impact factor: 8.661
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