INTRODUCTION: The prognostic significance of human epidermal growth factor 2 (HER2) overexpression in patients diagnosed with oesophageal cancer is controversial. We performed a systematic review and meta-analysis to determine the influence of HER2 overexpression and amplification on outcomes in operable oesophageal cancer. METHODS: MEDLINE and Embase (January 1990 to November 2011) was searched for translational studies that correlated HER2 expression with survival in operable oesophageal cancer. RESULTS: Fourteen studies involving 1,464 patients who had undergone potentially curative oesophagectomy for oesophageal cancer [322 (22%) HER2-positive] were included. Five-year mortality was significantly higher in HER2-positive patients [odds ratio (OR) 1.43, 95% confidence interval (CI) 1.04 to 1.95, p = 0.03]. Analysis related to histological cell type demonstrated significantly higher 5-year mortality in HER2-positive squamous cell carcinoma [OR 2.88, 95% CI 1.34 to 6.17, p = 0.006] and adenocarcinoma [OR 1.91, 95% CI 1.15 to 3.17, p = 0.01] on sensitivity analysis of higher-quality studies. CONCLUSION: HER2 overexpression and gene amplification in operable oesophageal cancer was an indicator of poor prognosis.
INTRODUCTION: The prognostic significance of human epidermal growth factor 2 (HER2) overexpression in patients diagnosed with oesophageal cancer is controversial. We performed a systematic review and meta-analysis to determine the influence of HER2 overexpression and amplification on outcomes in operable oesophageal cancer. METHODS: MEDLINE and Embase (January 1990 to November 2011) was searched for translational studies that correlated HER2 expression with survival in operable oesophageal cancer. RESULTS: Fourteen studies involving 1,464 patients who had undergone potentially curative oesophagectomy for oesophageal cancer [322 (22%) HER2-positive] were included. Five-year mortality was significantly higher in HER2-positive patients [odds ratio (OR) 1.43, 95% confidence interval (CI) 1.04 to 1.95, p = 0.03]. Analysis related to histological cell type demonstrated significantly higher 5-year mortality in HER2-positive squamous cell carcinoma [OR 2.88, 95% CI 1.34 to 6.17, p = 0.006] and adenocarcinoma [OR 1.91, 95% CI 1.15 to 3.17, p = 0.01] on sensitivity analysis of higher-quality studies. CONCLUSION:HER2 overexpression and gene amplification in operable oesophageal cancer was an indicator of poor prognosis.
Authors: N Normanno; C Bianco; L Strizzi; M Mancino; M R Maiello; A De Luca; F Caponigro; D S Salomon Journal: Curr Drug Targets Date: 2005-05 Impact factor: 3.465
Authors: T Nakamura; H Nekarda; A H Hoelscher; E Bollschweiler; N Harbeck; K Becker; J R Siewert; N ] Harbec N [corrected to Harbeck Journal: Cancer Date: 1994-04-01 Impact factor: 6.860
Authors: Whitfield B Growdon; Jolijn Groeneweg; Virginia Byron; Celeste DiGloria; Darrell R Borger; Rosemary Tambouret; Rosemary Foster; Ahmed Chenna; Jeff Sperinde; John Winslow; Bo R Rueda Journal: Gynecol Oncol Date: 2015-01-17 Impact factor: 5.482
Authors: Carrie L Robinson; Beth T Harrison; Azra H Ligon; Fei Dong; Valeria Maffeis; Ursula Matulonis; Marisa R Nucci; David L Kolin Journal: Mod Pathol Date: 2020-10-19 Impact factor: 7.842
Authors: L H McCormick Matthews; F Noble; J Tod; E Jaynes; S Harris; J N Primrose; C Ottensmeier; G J Thomas; T J Underwood Journal: Br J Cancer Date: 2015-06-25 Impact factor: 7.640