Literature DB >> 22840998

Making a noisy gene: HDACs turn up the static.

Roshan M Kumar1, James J Collins.   

Abstract

In this issue of Molecular Cell, Weinberger et al. (2012) find that particular histone deacetylases (HDACs) regulate distinct stages of transcription, implicating chromatin dynamics in the generation of gene-specific noise within populations of genetically identical cells.
Copyright © 2012 Elsevier Inc. All rights reserved.

Entities:  

Year:  2012        PMID： 22840998      PMCID： PMC3417138          DOI： 10.1016/j.molcel.2012.07.008

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  11 in total

1.  Regulation of noise in the expression of a single gene.

Authors:  Ertugrul M Ozbudak; Mukund Thattai; Iren Kurtser; Alan D Grossman; Alexander van Oudenaarden
Journal:  Nat Genet       Date:  2002-04-22       Impact factor: 38.330

2.  Noise in eukaryotic gene expression.

Authors:  William J Blake; Mads KAErn; Charles R Cantor; J J Collins
Journal:  Nature       Date:  2003-04-10       Impact factor: 49.962

3.  Stochastic gene expression in a single cell.

Authors:  Michael B Elowitz; Arnold J Levine; Eric D Siggia; Peter S Swain
Journal:  Science       Date:  2002-08-16       Impact factor: 47.728

4.  Tuning in to noise: epigenetics and intangible variation.

Authors:  Nadia C Whitelaw; Suyinn Chong; Emma Whitelaw
Journal:  Dev Cell       Date:  2010-11-16       Impact factor: 12.270

5.  Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity.

Authors:  Leor S Weinberger; John C Burnett; Jared E Toettcher; Adam P Arkin; David V Schaffer
Journal:  Cell       Date:  2005-07-29       Impact factor: 41.582

6.  Phenotypic consequences of promoter-mediated transcriptional noise.

Authors:  William J Blake; Gábor Balázsi; Michael A Kohanski; Farren J Isaacs; Kevin F Murphy; Yina Kuang; Charles R Cantor; David R Walt; James J Collins
Journal:  Mol Cell       Date:  2006-12-28       Impact factor: 17.970

Review 7.  The logic of chromatin architecture and remodelling at promoters.

Authors:  Bradley R Cairns
Journal:  Nature       Date:  2009-09-10       Impact factor: 49.962

8.  Transcription regulation through promoter-proximal pausing of RNA polymerase II.

Authors:  Leighton J Core; John T Lis
Journal:  Science       Date:  2008-03-28       Impact factor: 47.728

9.  Expression noise and acetylation profiles distinguish HDAC functions.

Authors:  Leehee Weinberger; Yoav Voichek; Itay Tirosh; Gil Hornung; Ido Amit; Naama Barkai
Journal:  Mol Cell       Date:  2012-06-07       Impact factor: 17.970

10.  Stochastic pulse regulation in bacterial stress response.

Authors:  James C W Locke; Jonathan W Young; Michelle Fontes; María Jesús Hernández Jiménez; Michael B Elowitz
Journal:  Science       Date:  2011-10-06       Impact factor: 47.728
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