Literature DB >> 18369138

Transcription regulation through promoter-proximal pausing of RNA polymerase II.

Leighton J Core1, John T Lis.   

Abstract

Recent work has shown that the RNA polymerase II enzyme pauses at a promoter-proximal site of many genes in Drosophila and mammals. This rate-limiting step occurs after recruitment and initiation of RNA polymerase II at a gene promoter. This stage in early elongation appears to be an important and broadly used target of gene regulation.

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Year:  2008        PMID： 18369138      PMCID： PMC2833332          DOI： 10.1126/science.1150843

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  26 in total

1.  RNA polymerase II promoter-proximal pausing upregulates c-fos gene expression.

Authors:  J Fivaz; M C Bassi; S Pinaud; J Mirkovitch
Journal:  Gene       Date:  2000-09-19       Impact factor: 3.688

2.  RNA polymerase II transcription complexes may become arrested if the nascent RNA is shortened to less than 50 nucleotides.

Authors:  Andrea Ujvári; Mahadeb Pal; Donal S Luse
Journal:  J Biol Chem       Date:  2002-06-26       Impact factor: 5.157

3.  Control of formation of two distinct classes of RNA polymerase II elongation complexes.

Authors:  N F Marshall; D H Price
Journal:  Mol Cell Biol       Date:  1992-05       Impact factor: 4.272

Review 4.  Elongation by RNA polymerase II: the short and long of it.

Authors:  Robert J Sims; Rimma Belotserkovskaya; Danny Reinberg
Journal:  Genes Dev       Date:  2004-10-15       Impact factor: 11.361

5.  Promoter-proximal pausing of RNA polymerase II defines a general rate-limiting step after transcription initiation.

Authors:  A Krumm; L B Hickey; M Groudine
Journal:  Genes Dev       Date:  1995-03-01       Impact factor: 11.361

6.  The beta -globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation.

Authors:  Tomoyuki Sawado; Jessica Halow; M A Bender; Mark Groudine
Journal:  Genes Dev       Date:  2003-04-02       Impact factor: 11.361

7.  Clustering of RNA polymerase B molecules in the 5' moiety of the adult beta-globin gene of hen erythrocytes.

Authors:  P Gariglio; M Bellard; P Chambon
Journal:  Nucleic Acids Res       Date:  1981-06-11       Impact factor: 16.971

8.  Global position and recruitment of HATs and HDACs in the yeast genome.

Authors:  François Robert; Dmitry K Pokholok; Nancy M Hannett; Nicola J Rinaldi; Mark Chandy; Alex Rolfe; Jerry L Workman; David K Gifford; Richard A Young
Journal:  Mol Cell       Date:  2004-10-22       Impact factor: 17.970

9.  RNA polymerase is poised for activation across the genome.

Authors:  Ginger W Muse; Daniel A Gilchrist; Sergei Nechaev; Ruchir Shah; Joel S Parker; Sherry F Grissom; Julia Zeitlinger; Karen Adelman
Journal:  Nat Genet       Date:  2007-11-11       Impact factor: 38.330

10.  The RNA polymerase II molecule at the 5' end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged.

Authors:  A E Rougvie; J T Lis
Journal:  Cell       Date:  1988-09-09       Impact factor: 41.582
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  212 in total

Review 1.  Controlling gene expression in response to stress.

Authors:  Eulàlia de Nadal; Gustav Ammerer; Francesc Posas
Journal:  Nat Rev Genet       Date:  2011-11-03       Impact factor: 53.242

2.  Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II.

Authors:  Humaira Gowher; Kevin Brick; R Daniel Camerini-Otero; Gary Felsenfeld
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-30       Impact factor: 11.205

3.  Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation.

Authors:  Sang-Hyun Song; AeRi Kim; Tobias Ragoczy; M A Bender; Mark Groudine; Ann Dean
Journal:  Blood       Date:  2010-06-22       Impact factor: 22.113

4.  Efficient and rapid nucleosome traversal by RNA polymerase II depends on a combination of transcript elongation factors.

Authors:  Donal S Luse; Lisa C Spangler; Andrea Újvári
Journal:  J Biol Chem       Date:  2010-12-22       Impact factor: 5.157

5.  Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation.

Authors:  Joanna Y Ip; Dominic Schmidt; Qun Pan; Arun K Ramani; Andrew G Fraser; Duncan T Odom; Benjamin J Blencowe
Journal:  Genome Res       Date:  2010-12-16       Impact factor: 9.043

Review 6.  The human Mediator complex: a versatile, genome-wide regulator of transcription.

Authors:  Dylan J Taatjes
Journal:  Trends Biochem Sci       Date:  2010-03-17       Impact factor: 13.807

7.  HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells.

Authors:  Jonathan E Reeder; Youn-Tae Kwak; Ryan P McNamara; Christian V Forst; Iván D'Orso
Journal:  Elife       Date:  2015-10-21       Impact factor: 8.140

8.  Collective Properties of a Transcription Initiation Model Under Varying Environment.

Authors:  Yucheng Hu; John S Lowengrub
Journal:  J Comput Biol       Date:  2015-12-08       Impact factor: 1.479

9.  Interferon-γ resets muscle cell fate by stimulating the sequential recruitment of JARID2 and PRC2 to promoters to repress myogenesis.

Authors:  Priya Londhe; Judith K Davie
Journal:  Sci Signal       Date:  2013-12-10       Impact factor: 8.192

10.  A conserved protein motif is required for full modulatory activity of negative elongation factor subunits NELF-A and NELF-B in modifying glucocorticoid receptor-regulated gene induction properties.

Authors:  Min Luo; Xinping Lu; Rong Zhu; Zhenhuan Zhang; Carson C Chow; Rong Li; S Stoney Simons
Journal:  J Biol Chem       Date:  2013-10-06       Impact factor: 5.157
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