Literature DB >> 22835719

Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2.

Ubaldina Galli1, Ornella Mesenzani, Camilla Coppo, Giovanni Sorba, Pier Luigi Canonico, Gian Cesare Tron, Armando A Genazzani.   

Abstract

As part of an effort to identify novel selective modulators of sirtuins, we synthesized and tested several isosteres and constrained analogues of nicotinamide. Biological data suggest that compound 2 is selective for Sirt3 over Sirt1 and Sirt2.
Copyright © 2012 Elsevier Masson SAS. All rights reserved.

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Year:  2012        PMID： 22835719     DOI： 10.1016/j.ejmech.2012.07.001

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  13 in total

1.  A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells.

Authors:  Turki Y Alhazzazi; Pachiyappan Kamarajan; Yanli Xu; Teng Ai; Liqiang Chen; Eric Verdin; Yvonne L Kapila
Journal:  Anticancer Res       Date:  2016-01       Impact factor: 2.480

2.  Sirtuin 3: A major control point for obesity-related metabolic diseases?

Authors:  Sean A Newsom; Kristen E Boyle; Jacob E Friedman
Journal:  Drug Discov Today Dis Mech       Date:  2013-06-01

3.  Sirtuin-3 (SIRT3) and the Hallmarks of Cancer.

Authors:  Turki Y Alhazzazi; Pachiyappan Kamarajan; Eric Verdin; Yvonne L Kapila
Journal:  Genes Cancer       Date:  2013-03

4.  5-O-Mycaminosyltylonolide antibacterial derivatives: design, synthesis and bioactivity.

Authors:  Akihiro Sugawara; Hitomi Maruyama; Sho Shibusawa; Hidehito Matsui; Tomoyasu Hirose; Ayumi Tsutsui; Robrecht Froyman; Carolin Ludwig; Johannes Koebberling; Hideaki Hanaki; Gerd Kleefeld; Satoshi Ōmura; Toshiaki Sunazuka
Journal:  J Antibiot (Tokyo)       Date:  2017-05-31       Impact factor: 2.649

5.  Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells.

Authors:  Rani Ojha; Ishaq Tantray; Suman Rimal; Siddhartha Mitra; Sam Cheshier; Bingwei Lu
Journal:  Dev Cell       Date:  2022-01-24       Impact factor: 12.270

6.  Atractylon inhibits the tumorigenesis of glioblastoma through SIRT3 signaling.

Authors:  Shanshan Sun; Jiali Shi; Xin Wang; Changgang Huang; Yuqian Huang; Jiayun Xu; Yuanyuan Jiang; Liying Cao; Tian Xie; Yongjie Wang; Zhihui Huang
Journal:  Am J Cancer Res       Date:  2022-05-15       Impact factor: 5.942

Review 7.  Mitochondrial Sirtuins in Cancer: Emerging Roles and Therapeutic Potential.

Authors:  Jasmine George; Nihal Ahmad
Journal:  Cancer Res       Date:  2016-04-20       Impact factor: 12.701

8.  Discovery of 2-(4-Acrylamidophenyl)-Quinoline-4-Carboxylic Acid Derivatives as Potent SIRT3 Inhibitors.

Authors:  Qian Hui; Xueming Li; Wenli Fan; Congying Gao; Lin Zhang; Hongyu Qin; Liuya Wei; Lei Zhang
Journal:  Front Chem       Date:  2022-03-30       Impact factor: 5.221

9.  SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin.

Authors:  Huifeng Pi; Shangcheng Xu; Russel J Reiter; Pan Guo; Lei Zhang; Yuming Li; Min Li; Zhenwang Cao; Li Tian; Jia Xie; Ruiqi Zhang; Mindi He; Yonghui Lu; Chuan Liu; Weixia Duan; Zhengping Yu; Zhou Zhou
Journal:  Autophagy       Date:  2015       Impact factor: 16.016

Review 10.  Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target.

Authors:  Jin Zhang; Honggang Xiang; Jie Liu; Yi Chen; Rong-Rong He; Bo Liu
Journal:  Theranostics       Date:  2020-07-09       Impact factor: 11.556
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