Literature DB >> 24020007

Sirtuin-3 (SIRT3) and the Hallmarks of Cancer.

Turki Y Alhazzazi1, Pachiyappan Kamarajan, Eric Verdin, Yvonne L Kapila.   

Abstract

Sirtuins (SIRT1-SIRT7), the mammalian homologs of the silent information regulator 2 (Sir2) in Saccharomyces cerevisiae, have been a major focus of study in the scientific community this past decade because of their emerging role in cancer biology and other age-related diseases. Emerging functions for this unique family of enzymes include roles in genomic stability, angiogenesis, metabolism, and anoikis. Here, we review recent developments on the role of sirtuins in cancer with a particular focus on SIRT3 and its role in the hallmarks of cancer and as a potential drug target for cancer treatment.

Entities:  

Keywords:  SIRT3; anoikis; cancer; sirtuin-3; sirtuins; tumor promoter; tumor suppressor

Year:  2013        PMID： 24020007      PMCID： PMC3764471          DOI： 10.1177/1947601913486351

Source DB:  PubMed          Journal:  Genes Cancer        ISSN： 1947-6019


  122 in total

1.  Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms.

Authors:  Jianjun Bao; Zhongping Lu; Joshua J Joseph; Darin Carabenciov; Christopher C Dimond; Liyan Pang; Leigh Samsel; J Philip McCoy; Jaime Leclerc; Phuongmai Nguyen; David Gius; Michael N Sack
Journal:  J Cell Biochem       Date:  2010-05       Impact factor: 4.429

2.  Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

Authors:  Raul Mostoslavsky; Katrin F Chua; David B Lombard; Wendy W Pang; Miriam R Fischer; Lionel Gellon; Pingfang Liu; Gustavo Mostoslavsky; Sonia Franco; Michael M Murphy; Kevin D Mills; Parin Patel; Joyce T Hsu; Andrew L Hong; Ethan Ford; Hwei-Ling Cheng; Caitlin Kennedy; Nomeli Nunez; Roderick Bronson; David Frendewey; Wojtek Auerbach; David Valenzuela; Margaret Karow; Michael O Hottiger; Stephen Hursting; J Carl Barrett; Leonard Guarente; Richard Mulligan; Bruce Demple; George D Yancopoulos; Frederick W Alt
Journal:  Cell       Date:  2006-01-27       Impact factor: 41.582

3.  Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis.

Authors:  Vladislav Temkin; Qiquan Huang; Hongtao Liu; Hiroyuki Osada; Richard M Pope
Journal:  Mol Cell Biol       Date:  2006-03       Impact factor: 4.272

Review 4.  Human cancers express mutator phenotypes: origin, consequences and targeting.

Authors:  Lawrence A Loeb
Journal:  Nat Rev Cancer       Date:  2011-05-19       Impact factor: 60.716

5.  p53 alterations in human squamous cell carcinomas and carcinoma cell lines.

Authors:  J Caamano; S Y Zhang; E A Rosvold; B Bauer; A J Klein-Szanto
Journal:  Am J Pathol       Date:  1993-04       Impact factor: 4.307

6.  SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways.

Authors:  Simon J Allison; Jo Milner
Journal:  Cell Cycle       Date:  2007-08-10       Impact factor: 4.534

7.  Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway.

Authors:  Vinodkumar B Pillai; Nagalingam R Sundaresan; Gene Kim; Madhu Gupta; Senthilkumar B Rajamohan; Jyothish B Pillai; Sadhana Samant; P V Ravindra; Ayman Isbatan; Mahesh P Gupta
Journal:  J Biol Chem       Date:  2009-11-24       Impact factor: 5.157

8.  Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.

Authors:  Eriko Michishita; Ronald A McCord; Lisa D Boxer; Matthew F Barber; Tao Hong; Or Gozani; Katrin F Chua
Journal:  Cell Cycle       Date:  2009-08-26       Impact factor: 4.534

9.  Mutation and cancer: statistical study of retinoblastoma.

Authors:  A G Knudson
Journal:  Proc Natl Acad Sci U S A       Date:  1971-04       Impact factor: 11.205

10.  Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.

Authors:  Rui-Hong Wang; Kundan Sengupta; Cuiling Li; Hyun-Seok Kim; Liu Cao; Cuiying Xiao; Sangsoo Kim; Xiaoling Xu; Yin Zheng; Beverly Chilton; Rong Jia; Zhi-Ming Zheng; Ettore Appella; Xin Wei Wang; Thomas Ried; Chu-Xia Deng
Journal:  Cancer Cell       Date:  2008-10-07       Impact factor: 31.743
View more
  24 in total

1.  A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells.

Authors:  Turki Y Alhazzazi; Pachiyappan Kamarajan; Yanli Xu; Teng Ai; Liqiang Chen; Eric Verdin; Yvonne L Kapila
Journal:  Anticancer Res       Date:  2016-01       Impact factor: 2.480

Review 2.  Iron and Cancer.

Authors:  Suzy V Torti; David H Manz; Bibbin T Paul; Nicole Blanchette-Farra; Frank M Torti
Journal:  Annu Rev Nutr       Date:  2018-08-21       Impact factor: 11.848

Review 3.  Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease.

Authors:  Xiaochen He; Heng Zeng; Jian-Xiong Chen
Journal:  J Cell Physiol       Date:  2018-08-21       Impact factor: 6.384

4.  4'-Bromo-resveratrol, a dual Sirtuin-1 and Sirtuin-3 inhibitor, inhibits melanoma cell growth through mitochondrial metabolic reprogramming.

Authors:  Jasmine George; Minakshi Nihal; Chandra K Singh; Nihal Ahmad
Journal:  Mol Carcinog       Date:  2019-07-10       Impact factor: 4.784

Review 5.  Interplay Between SIRT-3, Metabolism and Its Tumor Suppressor Role in Hepatocellular Carcinoma.

Authors:  Serena De Matteis; Anna Maria Granato; Roberta Napolitano; Chiara Molinari; Martina Valgiusti; Daniele Santini; Francesco Giuseppe Foschi; Giorgio Ercolani; Umberto Vespasiani Gentilucci; Luca Faloppi; Mario Scartozzi; Giovanni Luca Frassineti; Andrea Casadei Gardini
Journal:  Dig Dis Sci       Date:  2017-05-19       Impact factor: 3.199

6.  Kaempferol and Apigenin suppresses the stemness properties of TNBC cells by modulating Sirtuins.

Authors:  Abhilasha Sharma; Sonam Sinha; Harshita Keswani; Neeta Shrivastava
Journal:  Mol Divers       Date:  2022-02-07       Impact factor: 2.943

7.  Antimelanoma Effects of Concomitant Inhibition of SIRT1 and SIRT3 in BrafV600E/PtenNULL Mice.

Authors:  Gagan Chhabra; Chandra K Singh; Glorimar Guzmán-Pérez; Mary A Ndiaye; Kenneth A Iczkowski; Nihal Ahmad
Journal:  J Invest Dermatol       Date:  2021-09-29       Impact factor: 7.590

8.  Distinct Profiles for Mitochondrial t-RNAs and Small Nucleolar RNAs in Locally Invasive and Metastatic Colorectal Cancer.

Authors:  Lai Xu; Joseph Ziegelbauer; Rong Wang; Wells W Wu; Rong-Fong Shen; Hartmut Juhl; Yaqin Zhang; Amy Rosenberg
Journal:  Clin Cancer Res       Date:  2015-09-18       Impact factor: 12.531

Review 9.  Mitochondrial Sirtuins in Cancer: Emerging Roles and Therapeutic Potential.

Authors:  Jasmine George; Nihal Ahmad
Journal:  Cancer Res       Date:  2016-04-20       Impact factor: 12.701

10.  Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma.

Authors:  Jasmine George; Minakshi Nihal; Chandra K Singh; Weixiong Zhong; Xiaoqi Liu; Nihal Ahmad
Journal:  J Invest Dermatol       Date:  2015-12-29       Impact factor: 8.551
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.