Literature DB >> 23997790

Sirtuin 3: A major control point for obesity-related metabolic diseases?

Sean A Newsom1, Kristen E Boyle, Jacob E Friedman.   

Abstract

Obesity and obesity-related complications are epidemic issues currently plaguing much of the developed world with increasing associated morbidity, mortality, and economic burden. In this brief review, we discuss emerging evidence and remaining questions regarding the possible role for mitochondrial sirtuin 3 as a therapeutic target for the treatment of obesity-related metabolic diseases.

Entities:  

Year:  2013        PMID： 23997790      PMCID： PMC3756827          DOI： 10.1016/j.ddmec.2013.04.001

Source DB:  PubMed          Journal:  Drug Discov Today Dis Mech        ISSN： 1740-6765


  38 in total

1.  SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity.

Authors:  Zhongping Lu; Mohammed Bourdi; Jian H Li; Angel M Aponte; Yong Chen; David B Lombard; Marjan Gucek; Lance R Pohl; Michael N Sack
Journal:  EMBO Rep       Date:  2011-07-01       Impact factor: 8.807

2.  Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2.

Authors:  Ubaldina Galli; Ornella Mesenzani; Camilla Coppo; Giovanni Sorba; Pier Luigi Canonico; Gian Cesare Tron; Armando A Genazzani
Journal:  Eur J Med Chem       Date:  2012-07-15       Impact factor: 6.514

3.  Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux.

Authors:  Qijun Wang; Yakun Zhang; Chen Yang; Hui Xiong; Yan Lin; Jun Yao; Hong Li; Lu Xie; Wei Zhao; Yufeng Yao; Zhi-Bin Ning; Rong Zeng; Yue Xiong; Kun-Liang Guan; Shimin Zhao; Guo-Ping Zhao
Journal:  Science       Date:  2010-02-19       Impact factor: 47.728

4.  Regulation of cellular metabolism by protein lysine acetylation.

Authors:  Shimin Zhao; Wei Xu; Wenqing Jiang; Wei Yu; Yan Lin; Tengfei Zhang; Jun Yao; Li Zhou; Yaxue Zeng; Hong Li; Yixue Li; Jiong Shi; Wenlin An; Susan M Hancock; Fuchu He; Lunxiu Qin; Jason Chin; Pengyuan Yang; Xian Chen; Qunying Lei; Yue Xiong; Kun-Liang Guan
Journal:  Science       Date:  2010-02-19       Impact factor: 47.728

5.  Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria.

Authors:  Huseyin Cimen; Min-Joon Han; Yongjie Yang; Qiang Tong; Hasan Koc; Emine C Koc
Journal:  Biochemistry       Date:  2010-01-19       Impact factor: 3.162

6.  SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.

Authors:  Matthew D Hirschey; Tadahiro Shimazu; Eric Goetzman; Enxuan Jing; Bjoern Schwer; David B Lombard; Carrie A Grueter; Charles Harris; Sudha Biddinger; Olga R Ilkayeva; Robert D Stevens; Yu Li; Asish K Saha; Neil B Ruderman; James R Bain; Christopher B Newgard; Robert V Farese; Frederick W Alt; C Ronald Kahn; Eric Verdin
Journal:  Nature       Date:  2010-03-04       Impact factor: 49.962

7.  Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle.

Authors:  Orsolya M Palacios; Juan J Carmona; Shaday Michan; Ke Yun Chen; Yasuko Manabe; Jack Lee Ward; Laurie J Goodyear; Qiang Tong
Journal:  Aging (Albany NY)       Date:  2009-08-15       Impact factor: 5.682

8.  Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.

Authors:  Jintang Du; Yeyun Zhou; Xiaoyang Su; Jiu Jiu Yu; Saba Khan; Hong Jiang; Jungwoo Kim; Jimin Woo; Jun Huyn Kim; Brian Hyun Choi; Bin He; Wei Chen; Sheng Zhang; Richard A Cerione; Johan Auwerx; Quan Hao; Hening Lin
Journal:  Science       Date:  2011-11-11       Impact factor: 47.728

9.  Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity.

Authors:  Lydia W S Finley; Wilhelm Haas; Valérie Desquiret-Dumas; Douglas C Wallace; Vincent Procaccio; Steven P Gygi; Marcia C Haigis
Journal:  PLoS One       Date:  2011-08-17       Impact factor: 3.240

10.  A molecular mechanism for direct sirtuin activation by resveratrol.

Authors:  Melanie Gertz; Giang Thi Tuyet Nguyen; Frank Fischer; Benjamin Suenkel; Christine Schlicker; Benjamin Fränzel; Jana Tomaschewski; Firouzeh Aladini; Christian Becker; Dirk Wolters; Clemens Steegborn
Journal:  PLoS One       Date:  2012-11-21       Impact factor: 3.240
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  6 in total

Review 1.  Developmental programming of pediatric nonalcoholic fatty liver disease: redefining the"first hit".

Authors:  Michael S Stewart; Margaret J R Heerwagen; Jacob E Friedman
Journal:  Clin Obstet Gynecol       Date:  2013-09       Impact factor: 2.190

Review 2.  SIRT3 as a Regulator of Non-alcoholic Fatty Liver Disease.

Authors:  Eun-Hee Cho
Journal:  J Lifestyle Med       Date:  2014-09-30

3.  Hypoxia is associated with a lower expression of genes involved in lipogenesis in visceral adipose tissue.

Authors:  Eduardo García-Fuentes; Concepción Santiago-Fernández; Carolina Gutiérrez-Repiso; María D Mayas; Wilfredo Oliva-Olivera; Leticia Coín-Aragüez; Juan Alcaide; Luis Ocaña-Wilhelmi; Joan Vendrell; Francisco J Tinahones; Lourdes Garrido-Sánchez
Journal:  J Transl Med       Date:  2015-11-30       Impact factor: 5.531

4.  The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue.

Authors:  Ana Elena Peredo-Escárcega; Verónica Guarner-Lans; Israel Pérez-Torres; Sergio Ortega-Ocampo; Elizabeth Carreón-Torres; Vicente Castrejón-Tellez; Eulises Díaz-Díaz; María Esther Rubio-Ruiz
Journal:  Evid Based Complement Alternat Med       Date:  2015-11-01       Impact factor: 2.629

5.  Expression-based GWAS identifies variants, gene interactions and key regulators affecting intramuscular fatty acid content and composition in porcine meat.

Authors:  Anna Puig-Oliveras; Manuel Revilla; Anna Castelló; Ana I Fernández; Josep M Folch; Maria Ballester
Journal:  Sci Rep       Date:  2016-08-18       Impact factor: 4.379

Review 6.  Oxidative, Reductive, and Nitrosative Stress Effects on Epigenetics and on Posttranslational Modification of Enzymes in Cardiometabolic Diseases.

Authors:  I Pérez-Torres; M E Soto; V Castrejón-Tellez; M E Rubio-Ruiz; L Manzano Pech; V Guarner-Lans
Journal:  Oxid Med Cell Longev       Date:  2020-10-30       Impact factor: 6.543
  6 in total

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