Literature DB >> 22835699

Epigenetic regulation of stem cells differentiating along the neural lineage.

Volkan Coskun1, Rosemarie Tsoa, Yi E Sun.   

Abstract

Many lineage-specific genes are poised and silenced in stem cells. Upon differentiation, genes that are related to self-renewal and alternative lineages are stably silenced. CpG methylation at proximal promoters and PRC2-mediated H3K27me3 play a role in silencing genes temporarily or permanently, with or without coexistence of active epigenetic marks, respectively. Interestingly, DNA methylation on neuronal genes that is distal to transcription start site enable transcription activation owing to its ability to repel PRC2-mediated inhibition. In addition, DNA demethylase Tet proteins play a role in regulation of changes in DNA methylation and related H3K27me3 during differentiation. Collectively, a complex epigenetic network formed by H3K4me3, histone acetylation/deacetylation, H3K27me3 and DNA methylation/demethylation act together to regulate stem cell self-renewal and differentiation.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22835699      PMCID： PMC3489177          DOI： 10.1016/j.conb.2012.07.001

Source DB:  PubMed          Journal:  Curr Opin Neurobiol        ISSN： 0959-4388            Impact factor:   6.627


  44 in total

1.  Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts.

Authors:  Akiko Doi; In-Hyun Park; Bo Wen; Peter Murakami; Martin J Aryee; Rafael Irizarry; Brian Herb; Christine Ladd-Acosta; Junsung Rho; Sabine Loewer; Justine Miller; Thorsten Schlaeger; George Q Daley; Andrew P Feinberg
Journal:  Nat Genet       Date:  2009-11-01       Impact factor: 38.330

2.  Comprehensive methylome map of lineage commitment from haematopoietic progenitors.

Authors:  Hong Ji; Lauren I R Ehrlich; Jun Seita; Peter Murakami; Akiko Doi; Paul Lindau; Hwajin Lee; Martin J Aryee; Rafael A Irizarry; Kitai Kim; Derrick J Rossi; Matthew A Inlay; Thomas Serwold; Holger Karsunky; Lena Ho; George Q Daley; Irving L Weissman; Andrew P Feinberg
Journal:  Nature       Date:  2010-08-15       Impact factor: 49.962

3.  Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA.

Authors:  Aleksandra Szwagierczak; Sebastian Bultmann; Christine S Schmidt; Fabio Spada; Heinrich Leonhardt
Journal:  Nucleic Acids Res       Date:  2010-08-04       Impact factor: 16.971

4.  Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA.

Authors:  Shinwu Jeong; Gangning Liang; Shikhar Sharma; Joy C Lin; Si Ho Choi; Han Han; Christine B Yoo; Gerda Egger; Allen S Yang; Peter A Jones
Journal:  Mol Cell Biol       Date:  2009-07-20       Impact factor: 4.272

5.  Human DNA methylomes at base resolution show widespread epigenomic differences.

Authors:  Ryan Lister; Mattia Pelizzola; Robert H Dowen; R David Hawkins; Gary Hon; Julian Tonti-Filippini; Joseph R Nery; Leonard Lee; Zhen Ye; Que-Minh Ngo; Lee Edsall; Jessica Antosiewicz-Bourget; Ron Stewart; Victor Ruotti; A Harvey Millar; James A Thomson; Bing Ren; Joseph R Ecker
Journal:  Nature       Date:  2009-10-14       Impact factor: 49.962

6.  Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids.

Authors:  Lakshminarayan M Iyer; Mamta Tahiliani; Anjana Rao; L Aravind
Journal:  Cell Cycle       Date:  2009-06-27       Impact factor: 4.534

7.  Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes.

Authors:  Hao Wu; Volkan Coskun; Jifang Tao; Wei Xie; Weihong Ge; Kazuaki Yoshikawa; En Li; Yi Zhang; Yi Eve Sun
Journal:  Science       Date:  2010-07-23       Impact factor: 47.728

8.  Nucleosome-interacting proteins regulated by DNA and histone methylation.

Authors:  Till Bartke; Michiel Vermeulen; Blerta Xhemalce; Samuel C Robson; Matthias Mann; Tony Kouzarides
Journal:  Cell       Date:  2010-10-29       Impact factor: 41.582

9.  Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.

Authors:  Shinsuke Ito; Li Shen; Qing Dai; Susan C Wu; Leonard B Collins; James A Swenberg; Chuan He; Yi Zhang
Journal:  Science       Date:  2011-07-21       Impact factor: 47.728

10.  Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification.

Authors:  Shinsuke Ito; Ana C D'Alessio; Olena V Taranova; Kwonho Hong; Lawrence C Sowers; Yi Zhang
Journal:  Nature       Date:  2010-08-26       Impact factor: 49.962
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  16 in total

Review 1.  Epigenetic regulation of early neural fate commitment.

Authors:  Yunbo Qiao; Xianfa Yang; Naihe Jing
Journal:  Cell Mol Life Sci       Date:  2016-01-22       Impact factor: 9.261

2.  Ten-Eleven Translocation 1 and 2 Confer Overlapping Transcriptional Programs for the Proliferation of Cultured Adult Neural Stem Cells.

Authors:  Koji Shimozaki
Journal:  Cell Mol Neurobiol       Date:  2016-10-24       Impact factor: 5.046

3.  Epigenetic regulation of miR-302 by JMJD1C inhibits neural differentiation of human embryonic stem cells.

Authors:  Jianle Wang; Jung W Park; Hicham Drissi; Xiaofang Wang; Ren-He Xu
Journal:  J Biol Chem       Date:  2013-12-06       Impact factor: 5.157

4.  Unique patterns of trimethylation of histone H3 lysine 4 are prone to changes during aging in Caenorhabditis elegans somatic cells.

Authors:  Mintie Pu; Minghui Wang; Wenke Wang; Satheeja Santhi Velayudhan; Siu Sylvia Lee
Journal:  PLoS Genet       Date:  2018-06-18       Impact factor: 5.917

5.  Symmetrical Dose-Dependent DNA-Methylation Profiles in Children with Deletion or Duplication of 7q11.23.

Authors:  Emma Strong; Darci T Butcher; Rajat Singhania; Carolyn B Mervis; Colleen A Morris; Daniel De Carvalho; Rosanna Weksberg; Lucy R Osborne
Journal:  Am J Hum Genet       Date:  2015-07-09       Impact factor: 11.025

Review 6.  The roles of retinoic acid and retinoic acid receptors in inducing epigenetic changes.

Authors:  Alison Urvalek; Kristian Bruun Laursen; Lorraine J Gudas
Journal:  Subcell Biochem       Date:  2014

7.  Major epigenetic development distinguishing neuronal and non-neuronal cells occurs postnatally in the murine hypothalamus.

Authors:  Ge Li; Wenjuan Zhang; Maria S Baker; Eleonora Laritsky; Natalia Mattan-Hung; Dahai Yu; Govindarajan Kunde-Ramamoorthy; Richard B Simerly; Rui Chen; Lanlan Shen; Robert A Waterland
Journal:  Hum Mol Genet       Date:  2013-11-01       Impact factor: 6.150

8.  Single-cell-level spatial gene expression in the embryonic neural differentiation niche.

Authors:  Yi Huang; Xiaoming Yu; Na Sun; Nan Qiao; Yaqiang Cao; Jerome D Boyd-Kirkup; Qin Shen; Jing-Dong J Han
Journal:  Genome Res       Date:  2015-01-09       Impact factor: 9.043

9.  From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects.

Authors:  Nina V Balmer; Stefanie Klima; Eugen Rempel; Violeta N Ivanova; Raivo Kolde; Matthias K Weng; Kesavan Meganathan; Margit Henry; Agapios Sachinidis; Michael R Berthold; Jan G Hengstler; Jörg Rahnenführer; Tanja Waldmann; Marcel Leist
Journal:  Arch Toxicol       Date:  2014-06-17       Impact factor: 5.153

10.  Clonal relationships impact neuronal tuning within a phylogenetically ancient vertebrate brain structure.

Authors:  Alistair M Muldal; Timothy P Lillicrap; Blake A Richards; Colin J Akerman
Journal:  Curr Biol       Date:  2014-08-07       Impact factor: 10.834
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