BACKGROUND: MRI is a sensitive tool for the evaluation of synovitis in juvenile idiopathic arthritis (JIA). OBJECTIVE: The purpose of this study was to introduce a novel MRI-based score for synovitis in children and to examine its inter- and intraobserver variability in a multi-centre study. MATERIALS AND METHODS: Wrist MRI was performed in 76 children with JIA. On postcontrast 3-D spoiled gradient-echo and fat-suppressed T2-weighted spin-echo images, joint recesses were scored for the degree of synovial enhancement, effusion and overall inflammation independently by two paediatric radiologists. Total-enhancement and inflammation-synovitis scores were calculated. RESULTS: Interobserver agreement was poor to moderate for enhancement and inflammation in all recesses, except in the radioulnar and radiocarpal joints. Intraobserver agreement was good to excellent. For enhancement and inflammation scores, mean differences (95 % CI) between observers were -1.18 (-4.79 to 2.42) and -2.11 (-6.06 to 1.83). Intraobserver variability (reader 1) was 0 (-1.65 to 1.65) and 0.02 (-1.39 to 1.44). CONCLUSION: Intraobserver agreement was good. Except for the radioulnar and radiocarpal joints, interobserver agreement was not acceptable. Therefore, the proposed scoring system requires further refinement.
BACKGROUND: MRI is a sensitive tool for the evaluation of synovitis in juvenile idiopathic arthritis (JIA). OBJECTIVE: The purpose of this study was to introduce a novel MRI-based score for synovitis in children and to examine its inter- and intraobserver variability in a multi-centre study. MATERIALS AND METHODS: Wrist MRI was performed in 76 children with JIA. On postcontrast 3-D spoiled gradient-echo and fat-suppressed T2-weighted spin-echo images, joint recesses were scored for the degree of synovial enhancement, effusion and overall inflammation independently by two paediatric radiologists. Total-enhancement and inflammation-synovitis scores were calculated. RESULTS: Interobserver agreement was poor to moderate for enhancement and inflammation in all recesses, except in the radioulnar and radiocarpal joints. Intraobserver agreement was good to excellent. For enhancement and inflammation scores, mean differences (95 % CI) between observers were -1.18 (-4.79 to 2.42) and -2.11 (-6.06 to 1.83). Intraobserver variability (reader 1) was 0 (-1.65 to 1.65) and 0.02 (-1.39 to 1.44). CONCLUSION: Intraobserver agreement was good. Except for the radioulnar and radiocarpal joints, interobserver agreement was not acceptable. Therefore, the proposed scoring system requires further refinement.
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Authors: Derk Frederik Matthaus Avenarius; Charlotte Nusman; Clara Malattia; Laura Tanturri de Horatio; Karen Rosendahl; Mario Maas; Lil-Sofie Ording Müller Journal: Pediatr Radiol Date: 2018-05-08
Authors: Jeffrey M A van der Krogt; F Verkuil; E Charlotte van Gulik; Robert Hemke; J Merlijn van den Berg; Dieneke Schonenberg-Meinema; Angelika Kindermann; Koert M Dolman; Marc A Benninga; Taco W Kuijpers; Mario Maas; Charlotte M Nusman Journal: Rheumatol Int Date: 2021-11-22 Impact factor: 3.580
Authors: Charlotte M Nusman; Robert Hemke; Marc A Benninga; Dieneke Schonenberg-Meinema; Angelika Kindermann; Marion A J van Rossum; J Merlijn van den Berg; Mario Maas; Taco W Kuijpers Journal: Eur Radiol Date: 2015-08-02 Impact factor: 5.315
Authors: Charlotte M Nusman; Laura Tanturri de Horatio; Robert Hemke; E Charlotte van Gulik; Lil-Sofie Ording Müller; Clara Malattia; Derk Avenarius; Paolo Toma; Johannes Roth; Nikolay Tzaribachev; Silvia Magni-Manzoni; Mario Maas; Andrea S Doria; Karen Rosendahl Journal: Pediatr Radiol Date: 2018-01-13