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Literature DB >> 22832848

Alpha-mangostin suppresses MMP-2 and MMP-9 expression in head and neck squamous carcinoma cells.

Abstract

The purpose of this study was to investigate the effect of alpha-mangostin on matrix metalloproteinase (MMP)-2 and MMP-9 expression in head and neck squamous cell carcinoma (HNSCC). The human HNSCC cell lines were treated with alpha-mangostin and the cytotoxicity of alpha-mangostin in HNSCC was determined using the MTS assay. To determine the effect of alpha-mangostin on the expression of MMP-2 and MMP-9 in HNSCC, gelatin zymography and RT-PCR were performed. The results showed that alpha-mangostin increased in growth inhibition of HNSCC cell lines in a concentration-dependent manner. Treatment with alpha-mangostin decreased MMP-2 and MMP-9 expression in a concentration-dependent manner in all cell lines. These findings suggested that alpha-mangostin might be a potential therapeutic agent for HNSCC.

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Year: 2012 PMID： 22832848 DOI： 10.1007/s10266-012-0081-2

Source DB: PubMed Journal: Odontology ISSN： 1618-1247 Impact factor: 2.634

18 in total

1. Global cancer statistics.

Authors: D M Parkin; P Pisani; J Ferlay
Journal: CA Cancer J Clin Date: 1999 Jan-Feb Impact factor: 508.702

Review 2. Molecular parameters of head and neck cancer metastasis.

Authors: Sanjay L Bhave; Theodoras N Teknos; Quintin Pan
Journal: Crit Rev Eukaryot Gene Expr Date: 2011 Impact factor: 1.807

3. Prognostic value of MMP-2, -9 and TIMP-1,-2 immunoreactive protein at the invasive front in advanced head and neck squamous cell carcinomas.

Authors: Constanze Ondruschka; Peter Buhtz; Christiane Motsch; Bernd Freigang; Regine Schneider-Stock; Albert Roessner; Carsten Boltze
Journal: Pathol Res Pract Date: 2002 Impact factor: 3.250

Review 4. Matrix metalloproteinases: regulators of the tumor microenvironment.

Authors: Kai Kessenbrock; Vicki Plaks; Zena Werb
Journal: Cell Date: 2010-04-02 Impact factor: 41.582

5. α-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth.

Authors: Jeremy J Johnson; Sakina M Petiwala; Deeba N Syed; John T Rasmussen; Vaqar M Adhami; Imtiaz A Siddiqui; Amanda M Kohl; Hasan Mukhtar
Journal: Carcinogenesis Date: 2011-12-09 Impact factor: 4.944

6. Alpha-mangostin suppresses phorbol 12-myristate 13-acetate-induced MMP-2/MMP-9 expressions via alphavbeta3 integrin/FAK/ERK and NF-kappaB signaling pathway in human lung adenocarcinoma A549 cells.

Authors: Yuan-Wei Shih; Shang-Tao Chien; Pin-Shern Chen; Jian-Hui Lee; Shu-Hau Wu; Li-Te Yin
Journal: Cell Biochem Biophys Date: 2010-09 Impact factor: 2.194

Review 7. Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer.

Authors: Roopali Roy; Jiang Yang; Marsha A Moses
Journal: J Clin Oncol Date: 2009-09-08 Impact factor: 44.544

8. alpha-Mangostin, a novel dietary xanthone, suppresses TPA-mediated MMP-2 and MMP-9 expressions through the ERK signaling pathway in MCF-7 human breast adenocarcinoma cells.

Authors: Yuan-Bing Lee; Kung-Chung Ko; Ming-Der Shi; Yi-Chen Liao; Tai-An Chiang; Pei-Fen Wu; You-Xin Shih; Yuan-Wei Shih
Journal: J Food Sci Date: 2010 Jan-Feb Impact factor: 3.167

9. Characterized mechanism of alpha-mangostin-induced cell death: caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells.

Authors: Yoshihito Nakagawa; Munekazu Iinuma; Tomoki Naoe; Yoshinori Nozawa; Yukihiro Akao
Journal: Bioorg Med Chem Date: 2007-05-18 Impact factor: 3.641

10. α-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation.

Authors: Masa-Aki Shibata; Munekazu Iinuma; Junji Morimoto; Hitomi Kurose; Kanako Akamatsu; Yasushi Okuno; Yukihiro Akao; Yoshinori Otsuki
Journal: BMC Med Date: 2011-06-03 Impact factor: 8.775

8 in total

1. Alpha-2 Heremans Schmid Glycoprotein (AHSG) modulates signaling pathways in head and neck squamous cell carcinoma cell line SQ20B.

Authors: Pamela D Thompson; Amos Sakwe; Rainelli Koumangoye; Wendell G Yarbrough; Josiah Ochieng; Dana R Marshall
Journal: Exp Cell Res Date: 2013-12-12 Impact factor: 3.905

Alpha-mangostin suppresses MMP-2 and MMP-9 expression in head and neck squamous carcinoma cells.

1. Global cancer statistics.

Review 2. Molecular parameters of head and neck cancer metastasis.

3. Prognostic value of MMP-2, -9 and TIMP-1,-2 immunoreactive protein at the invasive front in advanced head and neck squamous cell carcinomas.

Review 4. Matrix metalloproteinases: regulators of the tumor microenvironment.

5. α-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth.

6. Alpha-mangostin suppresses phorbol 12-myristate 13-acetate-induced MMP-2/MMP-9 expressions via alphavbeta3 integrin/FAK/ERK and NF-kappaB signaling pathway in human lung adenocarcinoma A549 cells.

Review 7. Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer.

8. alpha-Mangostin, a novel dietary xanthone, suppresses TPA-mediated MMP-2 and MMP-9 expressions through the ERK signaling pathway in MCF-7 human breast adenocarcinoma cells.

9. Characterized mechanism of alpha-mangostin-induced cell death: caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells.

10. α-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation.

1. Alpha-2 Heremans Schmid Glycoprotein (AHSG) modulates signaling pathways in head and neck squamous cell carcinoma cell line SQ20B.

2. Inhibitory effect of alpha-mangostin on Candida biofilms.

3. Alpha-mangostin suppresses IL-6 and IL-8 expression in P. gingivalis LPS-stimulated human gingival fibroblasts.

4. α-Mangostin Induces Apoptosis and Cell Cycle Arrest in Oral Squamous Cell Carcinoma Cell.

5. Inhibitory Effect of Alpha-Mangostin on Adhesion of Candida albicans to Denture Acrylic.

6. Garcinone E induces apoptosis and inhibits migration and invasion in ovarian cancer cells.

7. Induction of Apoptosis and Inhibition of Epithelial Mesenchymal Transition by α-Mangostin in MG-63 Cell Lines.

8. Stimuli-responsive drug delivery systems for head and neck cancer therapy.