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Literature DB >> 22825424

The CENP-A nucleosome: a dynamic structure and role at the centromere.

Abstract

The centromere is a specialized locus that directs the formation of the kinetochore protein complex for correct chromosome segregation. The specific centromere histone H3 variant CENP-A has been described as the epigenetic mark of this chromatin region. Several laboratories have explored its properties, its partners, and its role in centromere formation. Specifically, two types of CENP-A nucleosomes have been described, suggesting there may be more complexity involved in centromere structure than previously thought. Recent work adds to this paradox by questioning the role of CENP-A as a unique centromeric mark and highlighting the assembly of a functional kinetochore in the absence of CENP-A. In this review, we discuss recent literature on the CENP-A nucleosomes and the debate on its role in kinetochore formation and centromere identity.

Entities: CellLine Chemical Disease Gene Species

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Year: 2012 PMID： 22825424 PMCID： PMC6309197 DOI： 10.1007/s10577-012-9301-4

Source DB: PubMed Journal: Chromosome Res ISSN： 0967-3849 Impact factor: 5.239

90 in total

1. Double-strand DNA breaks recruit the centromeric histone CENP-A.

Authors: Samantha G Zeitlin; Norman M Baker; Brian R Chapados; Evi Soutoglou; Jean Y J Wang; Michael W Berns; Don W Cleveland
Journal: Proc Natl Acad Sci U S A Date: 2009-08-28 Impact factor: 11.205

2. The centromeric nucleosome of budding yeast is perfectly positioned and covers the entire centromere.

Authors: Hope A Cole; Bruce H Howard; David J Clark
Journal: Proc Natl Acad Sci U S A Date: 2011-07-18 Impact factor: 11.205

3. Interaction of the histone (H3-H4)2 tetramer of the nucleosome with positively supercoiled DNA minicircles: Potential flipping of the protein from a left- to a right-handed superhelical form.

Authors: A Hamiche; V Carot; M Alilat; F De Lucia; M F O'Donohue; B Revet; A Prunell
Journal: Proc Natl Acad Sci U S A Date: 1996-07-23 Impact factor: 11.205

9. Centromere Protein (CENP)-W Interacts with Heterogeneous Nuclear Ribonucleoprotein (hnRNP) U and May Contribute to Kinetochore-Microtubule Attachment in Mitotic Cells.

Authors: Younghwa Chun; Raehyung Kim; Soojin Lee
Journal: PLoS One Date: 2016-02-16 Impact factor: 3.240

10. CENPT bridges adjacent CENPA nucleosomes on young human α-satellite dimers.

Authors: Jitendra Thakur; Steven Henikoff
Journal: Genome Res Date: 2016-07-06 Impact factor: 9.043

The CENP-A nucleosome: a dynamic structure and role at the centromere.

1. Double-strand DNA breaks recruit the centromeric histone CENP-A.

2. The centromeric nucleosome of budding yeast is perfectly positioned and covers the entire centromere.

3. Interaction of the histone (H3-H4)2 tetramer of the nucleosome with positively supercoiled DNA minicircles: Potential flipping of the protein from a left- to a right-handed superhelical form.

4. Crystal structure of the nucleosome core particle at 2.8 A resolution.

5. An octamer of histones in chromatin and free in solution.

6. Human centromere protein B induces translational positioning of nucleosomes on alpha-satellite sequences.

7. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP.

8. DNA binding of centromere protein C (CENPC) is stabilized by single-stranded RNA.

9. Analogous cleavage of DNA by micrococcal nuclease and a 1-10-phenanthroline-cuprous complex.

10. A map of nucleosome positions in yeast at base-pair resolution.

Review 1. Mechanisms of Nucleosome Dynamics In Vivo.

Review 2. Orchestrating the Specific Assembly of Centromeric Nucleosomes.

Review 3. Histone variants: The unsung guardians of the genome.

4. Role of helicase-like transcription factor (hltf) in the G2/m transition and apoptosis in brain.

5. Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3.

Review 6. Structure of centromere chromatin: from nucleosome to chromosomal architecture.

7. Fission Yeast CENP-C (Cnp3) Plays a Role in Restricting the Site of CENP-A Accumulation.

8. The budding yeast Centromere DNA Element II wraps a stable Cse4 hemisome in either orientation in vivo.

9. Centromere Protein (CENP)-W Interacts with Heterogeneous Nuclear Ribonucleoprotein (hnRNP) U and May Contribute to Kinetochore-Microtubule Attachment in Mitotic Cells.

10. CENPT bridges adjacent CENPA nucleosomes on young human α-satellite dimers.