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Literature DB >> 22824111

Transcriptomic biomarkers of cardiovascular disease.

Dawn M Pedrotty¹, Michael P Morley, Thomas P Cappola.

Abstract

Transcriptomics is the study of how our genes are regulated and expressed in different biological settings. Technical advances now enable quantitative assessment of all expressed genes (ie, the entire "transcriptome") in a given tissue at a given time. These approaches provide a powerful tool for understanding complex biological systems and for developing novel biomarkers. This chapter will introduce basic concepts in transcriptomics and available technologies for developing transcriptomic biomarkers. We will then review current and emerging applications in cardiovascular medicine.

Entities: Disease Gene Species

Mesh：

Substances：
Genetic Markers

Year: 2012 PMID： 22824111 PMCID： PMC4131429 DOI： 10.1016/j.pcad.2012.06.003

Source DB: PubMed Journal: Prog Cardiovasc Dis ISSN： 0033-0620 Impact factor: 8.194

57 in total

Review 1. RNA diagnostics: real-time RT-PCR strategies and promising novel target RNAs.

Authors: Günter Mayer; Jens Müller; Christina E Lünse
Journal: Wiley Interdiscip Rev RNA Date: 2010-09-27 Impact factor: 9.957

Review 2. Molecular testing in the management of cardiac transplant recipients: initial clinical experience.

Authors: Randall C Starling; Michael Pham; Hannah Valantine; Leslie Miller; Howard Eisen; E Rene Rodriguez; David O Taylor; Mohamad H Yamani; Jon Kobashigawa; Kenneth McCurry; Charles Marboe; Mandeep R Mehra; Andreas Zuckerman; Mario C Deng
Journal: J Heart Lung Transplant Date: 2006-12 Impact factor: 10.247

3. Universal noninvasive detection of solid organ transplant rejection.

Authors: Thomas M Snyder; Kiran K Khush; Hannah A Valantine; Stephen R Quake
Journal: Proc Natl Acad Sci U S A Date: 2011-03-28 Impact factor: 11.205

4. Multiple biomarkers for risk prediction in chronic heart failure.

Authors: Bonnie Ky; Benjamin French; Wayne C Levy; Nancy K Sweitzer; James C Fang; Alan H B Wu; Lee R Goldberg; Mariell Jessup; Thomas P Cappola
Journal: Circ Heart Fail Date: 2012-02-23 Impact factor: 8.790

Review 5. Functional genomics applied to cardiovascular medicine.

Authors: Thomas P Cappola; Kenneth B Margulies
Journal: Circulation Date: 2011-07-05 Impact factor: 29.690

Review 6. Clinical considerations of heritable factors in common heart failure.

Authors: Thomas P Cappola; Gerald W Dorn
Journal: Circ Cardiovasc Genet Date: 2011-12

7. Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome.

Authors: Christian Widera; Shashi K Gupta; Johan M Lorenzen; Claudia Bang; Johann Bauersachs; Kerstin Bethmann; Tibor Kempf; Kai C Wollert; Thomas Thum
Journal: J Mol Cell Cardiol Date: 2011-07-23 Impact factor: 5.000

8. Signature microRNA expression profile of essential hypertension and its novel link to human cytomegalovirus infection.

Authors: Shuqiang Li; Jianguo Zhu; Weili Zhang; Youren Chen; Ke Zhang; Laurentiu M Popescu; Xinliang Ma; Wayne Bond Lau; Rong Rong; Xueqing Yu; Bingbing Wang; Yafeng Li; Chuanshi Xiao; Mingming Zhang; Shuyan Wang; Liping Yu; Alex F Chen; Xinchun Yang; Jun Cai
Journal: Circulation Date: 2011-06-20 Impact factor: 29.690

9. DNA sequencing: clinical applications of new DNA sequencing technologies.

Authors: Frederick E Dewey; Stephen Pan; Matthew T Wheeler; Stephen R Quake; Euan A Ashley
Journal: Circulation Date: 2012-02-21 Impact factor: 29.690

10. Personal omics profiling reveals dynamic molecular and medical phenotypes.

Authors: Rui Chen; George I Mias; Jennifer Li-Pook-Than; Lihua Jiang; Hugo Y K Lam; Rong Chen; Elana Miriami; Konrad J Karczewski; Manoj Hariharan; Frederick E Dewey; Yong Cheng; Michael J Clark; Hogune Im; Lukas Habegger; Suganthi Balasubramanian; Maeve O'Huallachain; Joel T Dudley; Sara Hillenmeyer; Rajini Haraksingh; Donald Sharon; Ghia Euskirchen; Phil Lacroute; Keith Bettinger; Alan P Boyle; Maya Kasowski; Fabian Grubert; Scott Seki; Marco Garcia; Michelle Whirl-Carrillo; Mercedes Gallardo; Maria A Blasco; Peter L Greenberg; Phyllis Snyder; Teri E Klein; Russ B Altman; Atul J Butte; Euan A Ashley; Mark Gerstein; Kari C Nadeau; Hua Tang; Michael Snyder
Journal: Cell Date: 2012-03-16 Impact factor: 41.582

25 in total

1. Blood Gene Signatures of Chagas Cardiomyopathy With or Without Ventricular Dysfunction.

Authors: Ludmila Rodrigues Pinto Ferreira; Frederico Moraes Ferreira; Helder Imoto Nakaya; Xutao Deng; Darlan da Silva Cândido; Lea Campos de Oliveira; Jean-Noel Billaud; Marion C Lanteri; Vagner Oliveira-Carvalho Rigaud; Mark Seielstad; Jorge Kalil; Fabio Fernandes; Antonio Luiz P Ribeiro; Ester Cerdeira Sabino; Edecio Cunha-Neto
Journal: J Infect Dis Date: 2017-02-01 Impact factor: 5.226

2. C/VDdb: A multi-omics expression profiling database for a knowledge-driven approach in cardiovascular disease (CVD).

Authors: Marco Fernandes; Alisha Patel; Holger Husi
Journal: PLoS One Date: 2018-11-12 Impact factor: 3.240

3. Human Plasma Transcriptome Implicates Dysregulated S100A12 Expression: A Strong, Early-Stage Prognostic Factor in ST-Segment Elevated Myocardial Infarction: Bioinformatics Analysis and Experimental Verification.

Authors: Hu Zhai; Lei Huang; Yijie Gong; Yingwu Liu; Yu Wang; Bojiang Liu; Xiandong Li; Chunyan Peng; Tong Li
Journal: Front Cardiovasc Med Date: 2022-06-01

4. Transcriptome from circulating cells suggests dysregulated pathways associated with long-term recurrent events following first-time myocardial infarction.

Authors: Rahul Suresh; Xing Li; Anca Chiriac; Kashish Goel; Andre Terzic; Carmen Perez-Terzic; Timothy J Nelson
Journal: J Mol Cell Cardiol Date: 2014-05-04 Impact factor: 5.000

Review 5. Genetic epidemiology of type 2 diabetes and cardiovascular diseases in Africa.

Authors: Fasil Tekola-Ayele; Adebowale A Adeyemo; Charles N Rotimi
Journal: Prog Cardiovasc Dis Date: 2013 Nov-Dec Impact factor: 8.194

Review 6. Systems Biology and Noninvasive Imaging of Atherosclerosis.

Authors: Claudia Calcagno; Willem J M Mulder; Matthias Nahrendorf; Zahi A Fayad
Journal: Arterioscler Thromb Vasc Biol Date: 2016-02 Impact factor: 8.311

7. Transcriptomic heterogeneity of antibody mediated rejection after heart transplant with or without donor specific antibodies.

Authors: Benjamin S Mantell; Hector Cordero; Sarah B See; Kevin J Clerkin; Rodica Vasilescu; Charles C Marboe; Yoshifumi Naka; Susan Restaino; Paolo C Colombo; Linda J Addonizio; Maryjane A Farr; Emmanuel Zorn
Journal: J Heart Lung Transplant Date: 2021-07-08 Impact factor: 10.247