Literature DB >> 22810761

A new era of GPCR structural and chemical biology.

Sébastien Granier1, Brian Kobilka.   

Abstract

G protein-coupled receptors (GPCRs) are versatile molecular machines that regulate the majority of physiological responses to chemically diverse hormones and neurotransmitters. Recent breakthroughs in structural studies have advanced our understanding of GPCR signaling, particularly the selectivity of ligand recognition and receptor activation of G proteins.

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Year:  2012        PMID： 22810761      PMCID： PMC4031315          DOI： 10.1038/nchembio.1025

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  24 in total

1.  Crystal structure of rhodopsin: A G protein-coupled receptor.

Authors:  K Palczewski; T Kumasaka; T Hori; C A Behnke; H Motoshima; B A Fox; I Le Trong; D C Teller; T Okada; R E Stenkamp; M Yamamoto; M Miyano
Journal:  Science       Date:  2000-08-04       Impact factor: 47.728

Review 2.  Molecular tinkering of G protein-coupled receptors: an evolutionary success.

Authors:  J Bockaert; J P Pin
Journal:  EMBO J       Date:  1999-04-01       Impact factor: 11.598

3.  Differential targeting of Gbetagamma-subunit signaling with small molecules.

Authors:  Tabetha M Bonacci; Jennifer L Mathews; Chujun Yuan; David M Lehmann; Sundeep Malik; Dianqing Wu; Jose L Font; Jean M Bidlack; Alan V Smrcka
Journal:  Science       Date:  2006-04-21       Impact factor: 47.728

Review 4.  Conformational complexity of G-protein-coupled receptors.

Authors:  Brian K Kobilka; Xavier Deupi
Journal:  Trends Pharmacol Sci       Date:  2007-07-13       Impact factor: 14.819

Review 5.  Teaching old receptors new tricks: biasing seven-transmembrane receptors.

Authors:  Sudarshan Rajagopal; Keshava Rajagopal; Robert J Lefkowitz
Journal:  Nat Rev Drug Discov       Date:  2010-05       Impact factor: 84.694

6.  Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.

Authors:  Søren G F Rasmussen; Hee-Jung Choi; Daniel M Rosenbaum; Tong Sun Kobilka; Foon Sun Thian; Patricia C Edwards; Manfred Burghammer; Venkata R P Ratnala; Ruslan Sanishvili; Robert F Fischetti; Gebhard F X Schertler; William I Weis; Brian K Kobilka
Journal:  Nature       Date:  2007-10-21       Impact factor: 49.962

7.  GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function.

Authors:  Daniel M Rosenbaum; Vadim Cherezov; Michael A Hanson; Søren G F Rasmussen; Foon Sun Thian; Tong Sun Kobilka; Hee-Jung Choi; Xiao-Jie Yao; William I Weis; Raymond C Stevens; Brian K Kobilka
Journal:  Science       Date:  2007-10-25       Impact factor: 47.728

8.  The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist.

Authors:  Veli-Pekka Jaakola; Mark T Griffith; Michael A Hanson; Vadim Cherezov; Ellen Y T Chien; J Robert Lane; Adriaan P Ijzerman; Raymond C Stevens
Journal:  Science       Date:  2008-10-02       Impact factor: 47.728

Review 9.  New G-protein-coupled receptor crystal structures: insights and limitations.

Authors:  Brian Kobilka; Gebhard F X Schertler
Journal:  Trends Pharmacol Sci       Date:  2008-01-14       Impact factor: 14.819

10.  Structure of the δ-opioid receptor bound to naltrindole.

Authors:  Sébastien Granier; Aashish Manglik; Andrew C Kruse; Tong Sun Kobilka; Foon Sun Thian; William I Weis; Brian K Kobilka
Journal:  Nature       Date:  2012-05-16       Impact factor: 49.962
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  72 in total

1.  Fluorescent bioorthogonal labeling of class B GPCRs in live cells.

Authors:  Srikanth Kumar Gangam; Qing Lin
Journal:  Methods Enzymol       Date:  2020-06-15       Impact factor: 1.600

Review 2.  Structural and functional insights into the juxtamembranous amino-terminal tail and extracellular loop regions of class B GPCRs.

Authors:  M Dong; C Koole; D Wootten; P M Sexton; L J Miller
Journal:  Br J Pharmacol       Date:  2014-03       Impact factor: 8.739

3.  Molecular modeling studies give hint for the existence of a symmetric hβ₂R-Gαβγ-homodimer.

Authors:  Andrea Straßer; Hans-Joachim Wittmann
Journal:  J Mol Model       Date:  2013-08-08       Impact factor: 1.810

4.  Does the Lipid Bilayer Orchestrate Access and Binding of Ligands to Transmembrane Orthosteric/Allosteric Sites of G Protein-Coupled Receptors?

Authors:  Christopher T Szlenk; Jeevan B Gc; Senthil Natesan
Journal:  Mol Pharmacol       Date:  2019-04-08       Impact factor: 4.436

5.  Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells.

Authors:  Rabia U Malik; Michael Ritt; Brian T DeVree; Richard R Neubig; Roger K Sunahara; Sivaraj Sivaramakrishnan
Journal:  J Biol Chem       Date:  2013-04-29       Impact factor: 5.157

Review 6.  Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway.

Authors:  E A M Bouwens; F Stavenuiter; L O Mosnier
Journal:  J Thromb Haemost       Date:  2013-06       Impact factor: 5.824

7.  Retinal ligand mobility explains internal hydration and reconciles active rhodopsin structures.

Authors:  Nicholas Leioatts; Blake Mertz; Karina Martínez-Mayorga; Tod D Romo; Michael C Pitman; Scott E Feller; Alan Grossfield; Michael F Brown
Journal:  Biochemistry       Date:  2014-01-08       Impact factor: 3.162

Review 8.  Modelling three-dimensional protein structures for applications in drug design.

Authors:  Tobias Schmidt; Andreas Bergner; Torsten Schwede
Journal:  Drug Discov Today       Date:  2013-11-08       Impact factor: 7.851

9.  Higher-order assemblies in a new paradigm of signal transduction.

Authors:  Hao Wu
Journal:  Cell       Date:  2013-04-11       Impact factor: 41.582

10.  Engineering Salt Bridge Networks between Transmembrane Helices Confers Thermostability in G-Protein-Coupled Receptors.

Authors:  Soumadwip Ghosh; Tobias Bierig; Sangbae Lee; Suvamay Jana; Adelheid Löhle; Gisela Schnapp; Christofer S Tautermann; Nagarajan Vaidehi
Journal:  J Chem Theory Comput       Date:  2018-11-06       Impact factor: 6.006
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