OBJECTIVE: Impulsivity, conceptualized as impairment in planning and poor attentional and inhibitory control, is a key feature of bipolar disorder. Familial risk for bipolar disorder is known to affect inhibitory control but its impact on the attentional and planning dimensions of impulsivity is still unclear. METHODS: We administered the Barratt Impulsiveness Scale, version 11 (BIS-11) to 54 euthymic individuals with DSM-IV bipolar I disorder, 57 of their clinically unaffected siblings, and 49 healthy comparison subjects. Groups were compared on the attentional (rapid shifts in attention/impatience with complexity), motor (acting impetuously), and non-planning (absence of weighing upon long-term consequences of actions) subscales of the BIS-11, and on total BIS-11 score. To investigate functional implications of trait impulsivity, total BIS-11 score was examined in relation to current psychosocial functioning and criminal history. RESULTS: Individuals with bipolar I disorder had elevated scores compared to healthy comparison subjects on BIS-11 total score and all three subscales (p < 0.0001). Unaffected siblings had elevated BIS-11 total score (p = 0.0037), motor (p = 0.0027), and non-planning (p = 0.0379) subscales in comparison to unrelated healthy controls. Total BIS-11 score was negatively associated with global assessment of functioning (GAF) score (β = -0.32, p < 0.0001). CONCLUSIONS: Our results suggest that impulsivity is sensitive to familial liability for the illness, making it a potential endophenotype for bipolar disorder.
OBJECTIVE: Impulsivity, conceptualized as impairment in planning and poor attentional and inhibitory control, is a key feature of bipolar disorder. Familial risk for bipolar disorder is known to affect inhibitory control but its impact on the attentional and planning dimensions of impulsivity is still unclear. METHODS: We administered the Barratt Impulsiveness Scale, version 11 (BIS-11) to 54 euthymic individuals with DSM-IV bipolar I disorder, 57 of their clinically unaffected siblings, and 49 healthy comparison subjects. Groups were compared on the attentional (rapid shifts in attention/impatience with complexity), motor (acting impetuously), and non-planning (absence of weighing upon long-term consequences of actions) subscales of the BIS-11, and on total BIS-11 score. To investigate functional implications of trait impulsivity, total BIS-11 score was examined in relation to current psychosocial functioning and criminal history. RESULTS: Individuals with bipolar I disorder had elevated scores compared to healthy comparison subjects on BIS-11 total score and all three subscales (p < 0.0001). Unaffected siblings had elevated BIS-11 total score (p = 0.0037), motor (p = 0.0027), and non-planning (p = 0.0379) subscales in comparison to unrelated healthy controls. Total BIS-11 score was negatively associated with global assessment of functioning (GAF) score (β = -0.32, p < 0.0001). CONCLUSIONS: Our results suggest that impulsivity is sensitive to familial liability for the illness, making it a potential endophenotype for bipolar disorder.
Authors: David C Glahn; Joanne E Curran; Anderson M Winkler; Melanie A Carless; Jack W Kent; Jac C Charlesworth; Matthew P Johnson; Harald H H Göring; Shelley A Cole; Thomas D Dyer; Eric K Moses; Rene L Olvera; Peter Kochunov; Ravi Duggirala; Peter T Fox; Laura Almasy; John Blangero Journal: Biol Psychiatry Date: 2011-10-07 Impact factor: 13.382
Authors: Alan C Swann; Marijn Lijffijt; Scott D Lane; Kimberly L Kjome; Joel L Steinberg; F Gerard Moeller Journal: Bipolar Disord Date: 2011-03 Impact factor: 6.744
Authors: Stephen M Strakowski; David E Fleck; Melissa P DelBello; Caleb M Adler; Paula K Shear; Renu Kotwal; Stephan Arndt Journal: Bipolar Disord Date: 2010-05 Impact factor: 6.744
Authors: Tommy H Ng; Jonathan P Stange; Chelsea L Black; Madison K Titone; Rachel B Weiss; Lyn Y Abramson; Lauren B Alloy Journal: J Affect Disord Date: 2016-03-15 Impact factor: 4.839
Authors: Danella M Hafeman; John Merranko; David Axelson; Benjamin I Goldstein; Tina Goldstein; Kelly Monk; Mary Beth Hickey; Dara Sakolsky; Rasim Diler; Satish Iyengar; David Brent; David Kupfer; Boris Birmaher Journal: Am J Psychiatry Date: 2016-02-19 Impact factor: 18.112
Authors: Manpreet K Singh; Kiki D Chang; Ryan G Kelley; Manish Saggar; Allan L Reiss; Ian H Gotlib Journal: Bipolar Disord Date: 2014-06-17 Impact factor: 6.744
Authors: L Felice Reddy; Junghee Lee; Michael C Davis; Lori Altshuler; David C Glahn; David J Miklowitz; Michael F Green Journal: Neuropsychopharmacology Date: 2013-08-21 Impact factor: 7.853