Tommy H Ng1, Jonathan P Stange1, Chelsea L Black1, Madison K Titone1, Rachel B Weiss2, Lyn Y Abramson3, Lauren B Alloy4. 1. Department of Psychology, Temple University, United States. 2. Department of Psychiatry, McLean Hospital/Harvard Medical School, Unites States. 3. Department of Psychology, University of Wisconsin-Madison, Unites States. 4. Department of Psychology, Temple University, United States. Electronic address: lalloy@temple.edu.
Abstract
BACKGROUND: A growing body of research suggests that bipolar disorders (BD) are associated with high impulsivity. Using a multi-method approach, the current study provided the first examination of the hypothesis that impulsivity would prospectively predict shorter time to onset of DSM-IV-TR or RDC hypomanic or manic episodes in a sample selected based on reward sensitivity, a biobehavioral trait shown to predict onset and course of BD. METHODS: 163 participants with high reward sensitivity and 114 participants with moderate reward sensitivity were followed every six months for an average of 2.68 years. Participants completed the Barratt Impulsiveness Scale - Version 11 (BIS-11), Balloon Analog Risk Task (BART), Beck Depression Inventory, Altman Self-Rating Mania Scale, and an expanded Schedule for Affective Disorders and Schizophrenia (exp-SADS) - Lifetime Version at baseline and were followed prospectively with the exp-SADS - Change Version to assess onset of hypomanic or manic episodes and treatment seeking for mood problems. RESULTS: Cox proportional hazard regression analyses indicated that impulsivity as measured by a behavioral task (BART; OR=1.04, p=.03) and a self-report measure (BIS-11 Attentional Impulsiveness subscale; OR=1.16, p=.01) predicted shorter time to hypomania/mania onset, after controlling for baseline depressive and manic symptoms, family history of mood disorder, treatment seeking for mood problems, and reward sensitivity. LIMITATIONS: The study was limited by non-comprehensive assessment of impulsivity and unknown generalizability to clinical samples. CONCLUSIONS: Impulsivity confers vulnerability to hypomania or mania. Future studies would benefit from considering how impulsivity can be integrated into existing biopsychosocial models of BD.
BACKGROUND: A growing body of research suggests that bipolar disorders (BD) are associated with high impulsivity. Using a multi-method approach, the current study provided the first examination of the hypothesis that impulsivity would prospectively predict shorter time to onset of DSM-IV-TR or RDC hypomanic or manic episodes in a sample selected based on reward sensitivity, a biobehavioral trait shown to predict onset and course of BD. METHODS: 163 participants with high reward sensitivity and 114 participants with moderate reward sensitivity were followed every six months for an average of 2.68 years. Participants completed the Barratt Impulsiveness Scale - Version 11 (BIS-11), Balloon Analog Risk Task (BART), Beck Depression Inventory, Altman Self-Rating Mania Scale, and an expanded Schedule for Affective Disorders and Schizophrenia (exp-SADS) - Lifetime Version at baseline and were followed prospectively with the exp-SADS - Change Version to assess onset of hypomanic or manic episodes and treatment seeking for mood problems. RESULTS: Cox proportional hazard regression analyses indicated that impulsivity as measured by a behavioral task (BART; OR=1.04, p=.03) and a self-report measure (BIS-11Attentional Impulsiveness subscale; OR=1.16, p=.01) predicted shorter time to hypomania/mania onset, after controlling for baseline depressive and manic symptoms, family history of mood disorder, treatment seeking for mood problems, and reward sensitivity. LIMITATIONS: The study was limited by non-comprehensive assessment of impulsivity and unknown generalizability to clinical samples. CONCLUSIONS: Impulsivity confers vulnerability to hypomania or mania. Future studies would benefit from considering how impulsivity can be integrated into existing biopsychosocial models of BD.
Authors: Lauren B Alloy; Lyn Y Abramson; Patricia D Walshaw; Alex Cogswell; Louisa D Grandin; Megan E Hughes; Brian M Iacoviello; Wayne G Whitehouse; Snezana Urosevic; Robin Nusslock; Michael E Hogan Journal: Bipolar Disord Date: 2008-03 Impact factor: 6.744
Authors: Erica L Dawson; Paula K Shear; Steven R Howe; Caleb M Adler; Melissa P DelBello; David E Fleck; Stephen M Strakowski Journal: Bipolar Disord Date: 2014-07-16 Impact factor: 6.744
Authors: Tommy H Ng; Taylor A Burke; Jonathan P Stange; Patricia D Walshaw; Rachel B Weiss; Snezana Urosevic; Lyn Y Abramson; Lauren B Alloy Journal: J Abnorm Psychol Date: 2017-04
Authors: Tommy H Ng; Rachel D Freed; Madison K Titone; Jonathan P Stange; Rachel B Weiss; Lyn Y Abramson; Lauren B Alloy Journal: Behav Ther Date: 2016-08-31
Authors: Elisa Sophie Strasser; Paula Haffner; Jana Fiebig; Esther Quinlivan; Mazda Adli; Thomas Josef Stamm Journal: Int J Bipolar Disord Date: 2016-08-17
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Authors: Sajedeh Hamidian; Abbas Pourshahbaz; Ali Bozorgmehr; Esmaeil Shahsavand Ananloo; Behrooz Dolatshahi; Mina Ohadi Journal: Ann Gen Psychiatry Date: 2020-05-09 Impact factor: 3.455
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