BACKGROUND: Trait functional abnormalities in BD patients have only been reported in the ventral prefrontal cortex (VPFC). We examined whether deficits in VPFC-related inhibitory processes, but not dorsal prefrontal (DPFC) based executive functions, represent an endophenotypic marker for bipolar disorder I (BDI). METHODS: We used the Wisconsin Card Sorting Test (WCST), commonly associated with DPFC function, and the Hayling Sentence Completion Task (HSCT) which engages the VPFC. Performance on these tests of 43 healthy participants was compared to that of 10 remitted BDI patients and 15 of their unaffected offspring. RESULTS: Compared to healthy participants, patients and their offspring made more errors in the HSCT but offspring achieved more categories and made fewer perseverative errors in the WCST. CONCLUSIONS: Impaired response inhibition, predominantly a VPFC related function, may reflect familial predisposition to BDI while deficits in rule attainment, a DPFC based function, may be associated only with the clinical phenotype.
BACKGROUND: Trait functional abnormalities in BDpatients have only been reported in the ventral prefrontal cortex (VPFC). We examined whether deficits in VPFC-related inhibitory processes, but not dorsal prefrontal (DPFC) based executive functions, represent an endophenotypic marker for bipolar disorder I (BDI). METHODS: We used the Wisconsin Card Sorting Test (WCST), commonly associated with DPFC function, and the Hayling Sentence Completion Task (HSCT) which engages the VPFC. Performance on these tests of 43 healthy participants was compared to that of 10 remitted BDI patients and 15 of their unaffected offspring. RESULTS: Compared to healthy participants, patients and their offspring made more errors in the HSCT but offspring achieved more categories and made fewer perseverative errors in the WCST. CONCLUSIONS: Impaired response inhibition, predominantly a VPFC related function, may reflect familial predisposition to BDI while deficits in rule attainment, a DPFC based function, may be associated only with the clinical phenotype.
Authors: Tomas Hajek; Jeffrey Cullis; Tomas Novak; Miloslav Kopecek; Ryan Blagdon; Lukas Propper; Pavla Stopkova; Anne Duffy; Cyril Hoschl; Rudolf Uher; Tomas Paus; L Trevor Young; Martin Alda Journal: Biol Psychiatry Date: 2012-07-20 Impact factor: 13.382
Authors: Heidi W Thermenos; Nikos Makris; Susan Whitfield-Gabrieli; Ariel B Brown; Anthony J Giuliano; Erica H Lee; Stephen V Faraone; Ming T Tsuang; Larry J Seidman Journal: Bipolar Disord Date: 2011-05 Impact factor: 6.744
Authors: Lauren E Lombardo; Carrie E Bearden; Jennifer Barrett; Margaret S Brumbaugh; Brian Pittman; Sophia Frangou; David C Glahn Journal: Bipolar Disord Date: 2012-07-16 Impact factor: 6.744
Authors: A E Doyle; J Wozniak; T E Wilens; A Henin; L J Seidman; C Petty; R Fried; L M Gross; S V Faraone; J Biederman Journal: Psychol Med Date: 2008-12-11 Impact factor: 7.723