BACKGROUND AND PURPOSE: The present study was designed to map the alteration of white matter in primary open-angle glaucoma (POAG) by applying tract-based spatial statistics (TBSS) analysis. METHODS: Diffusion tensor imaging (DTI) data from MRI brain scans were collected from 15 POAG patients and 15 gender- and age-matched non-glaucoma controls using a SIEMENS Trio 3.0-Tesla scanner. For the white-matter analysis, DTI images were processed using FSL software (http://www.fmrib.ox.ac.uk/fsl/index.html). Fractional anisotropy (FA) between the POAG and control groups was compared by TBSS analysis corrected for multiple comparisons using threshold-free cluster enhancement (TFCE). RESULTS: Compared with non-glaucoma subjects, the occipital white matter in POAG patients had significantly lower FA values (p<0.05, corrected). CONCLUSION: The change in white-matter FA may indicate atrophy of the visual cortex that may be important in the diagnosis and treatment of POAG patients.
BACKGROUND AND PURPOSE: The present study was designed to map the alteration of white matter in primary open-angle glaucoma (POAG) by applying tract-based spatial statistics (TBSS) analysis. METHODS: Diffusion tensor imaging (DTI) data from MRI brain scans were collected from 15 POAG patients and 15 gender- and age-matched non-glaucoma controls using a SIEMENS Trio 3.0-Tesla scanner. For the white-matter analysis, DTI images were processed using FSL software (http://www.fmrib.ox.ac.uk/fsl/index.html). Fractional anisotropy (FA) between the POAG and control groups was compared by TBSS analysis corrected for multiple comparisons using threshold-free cluster enhancement (TFCE). RESULTS: Compared with non-glaucoma subjects, the occipital white matter in POAG patients had significantly lower FA values (p<0.05, corrected). CONCLUSION: The change in white-matter FA may indicate atrophy of the visual cortex that may be important in the diagnosis and treatment of POAG patients.
Authors: Zhe Sun; Carlos Parra; Ji Won Bang; Els Fieremans; Gadi Wollstein; Joel S Schuman; Kevin C Chan Journal: Annu Int Conf IEEE Eng Med Biol Soc Date: 2020-07
Authors: Holly D H Brown; Rachel L Woodall; Rebecca E Kitching; Heidi A Baseler; Antony B Morland Journal: Ophthalmic Physiol Opt Date: 2016-05 Impact factor: 3.117