Shumpei Ogawa1, Hiromasa Takemura2, Hiroshi Horiguchi3, Masahiko Terao4, Tomoki Haji5, Franco Pestilli6, Jason D Yeatman6, Hiroshi Tsuneoka3, Brian A Wandell6, Yoichiro Masuda7. 1. Department of Psychology, Stanford University, Stanford, California, United States Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan. 2. Department of Psychology, Stanford University, Stanford, California, United States Department of Psychology, The University of Tokyo, Tokyo, Japan. 3. Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan. 4. Department of Psychology, The University of Tokyo, Tokyo, Japan Tamagawa University Brain Science Institute, Machida, Japan. 5. Department of Ophthalmology, Atsugi City Hospital, Kanagawa, Japan. 6. Department of Psychology, Stanford University, Stanford, California, United States. 7. Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan The Japan Society for the Promotion of Science, Tokyo, Japan.
Abstract
PURPOSE: Patients with Leber hereditary optic neuropathy (LHON) and cone-rod dystrophy (CRD) have central vision loss; but CRD damages the retinal photoreceptor layer, and LHON damages the retinal ganglion cell (RGC) layer. Using diffusion MRI, we measured how these two types of retinal damage affect the optic tract (ganglion cell axons) and optic radiation (geniculo-striate axons). METHODS: Adult onset CRD (n = 5), LHON (n = 6), and healthy controls (n = 14) participated in the study. We used probabilistic fiber tractography to identify the optic tract and the optic radiation. We compared axial and radial diffusivity at many positions along the optic tract and the optic radiation. RESULTS: In both types of patients, diffusion measures within the optic tract and the optic radiation differ from controls. The optic tract change is principally a decrease in axial diffusivity; the optic radiation change is principally an increase in radial diffusivity. CONCLUSIONS: Both photoreceptor layer (CRD) and retinal ganglion cell (LHON) retinal disease causes substantial change in the visual white matter. These changes can be measured using diffusion MRI. The diffusion changes measured in the optic tract and the optic radiation differ, suggesting that they are caused by different biological mechanisms. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
PURPOSE:Patients with Leber hereditary optic neuropathy (LHON) and cone-rod dystrophy (CRD) have central vision loss; but CRD damages the retinal photoreceptor layer, and LHON damages the retinal ganglion cell (RGC) layer. Using diffusion MRI, we measured how these two types of retinal damage affect the optic tract (ganglion cell axons) and optic radiation (geniculo-striate axons). METHODS: Adult onset CRD (n = 5), LHON (n = 6), and healthy controls (n = 14) participated in the study. We used probabilistic fiber tractography to identify the optic tract and the optic radiation. We compared axial and radial diffusivity at many positions along the optic tract and the optic radiation. RESULTS: In both types of patients, diffusion measures within the optic tract and the optic radiation differ from controls. The optic tract change is principally a decrease in axial diffusivity; the optic radiation change is principally an increase in radial diffusivity. CONCLUSIONS: Both photoreceptor layer (CRD) and retinal ganglion cell (LHON) retinal disease causes substantial change in the visual white matter. These changes can be measured using diffusion MRI. The diffusion changes measured in the optic tract and the optic radiation differ, suggesting that they are caused by different biological mechanisms. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
Entities:
Keywords:
Leber hereditary optic neuropathy; cone-rod dystrophy; diffusion-MRI; white matter
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