OBJECTIVE: To determine placental characteristics associated with neonatal encephalopathy (NE) and correlate these with short- and long-term neurodevelopmental outcome. DESIGN: Case/control study. SETTING: Neonatal Intensive Care Unit, Rotunda Hospital, Dublin, Ireland. PATIENTS: Newborns ≥36 weeks gestation, with NE (cases). Healthy term newborns (controls). INTERVENTIONS: Placental pathology was obtained from the official placental report. Brain MRI was blindly reviewed. Children were assessed using a variety of standardised assessments. Data were analysed using multinomial logistic regression analysis. MAIN OUTCOME MEASURES: RRR for grade of encephalopathy. OR for neurodevelopmental outcome. RESULTS: Placental reports were available on 141 cases (76 grade 1; 46 grade 2; 19 grade 3) and 309 control infants. Meconium phagocytosis, haemorrhage, raised placental to birth weight ratio and/or markers of infection/inflammation were independently associated with NE and showed a synergistic effect, when combined, for short- and long-term impairments. CONCLUSIONS: Evaluation of the mechanisms leading to the placental characteristics identified may help to characterise the causal pathway of NE.
OBJECTIVE: To determine placental characteristics associated with neonatal encephalopathy (NE) and correlate these with short- and long-term neurodevelopmental outcome. DESIGN: Case/control study. SETTING: Neonatal Intensive Care Unit, Rotunda Hospital, Dublin, Ireland. PATIENTS: Newborns ≥36 weeks gestation, with NE (cases). Healthy term newborns (controls). INTERVENTIONS: Placental pathology was obtained from the official placental report. Brain MRI was blindly reviewed. Children were assessed using a variety of standardised assessments. Data were analysed using multinomial logistic regression analysis. MAIN OUTCOME MEASURES: RRR for grade of encephalopathy. OR for neurodevelopmental outcome. RESULTS: Placental reports were available on 141 cases (76 grade 1; 46 grade 2; 19 grade 3) and 309 control infants. Meconium phagocytosis, haemorrhage, raised placental to birth weight ratio and/or markers of infection/inflammation were independently associated with NE and showed a synergistic effect, when combined, for short- and long-term impairments. CONCLUSIONS: Evaluation of the mechanisms leading to the placental characteristics identified may help to characterise the causal pathway of NE.
Authors: C M C Frank; P G J Nikkels; J C Harteman; I C van Haastert; M J N L Benders; C Koopman-Esseboom; L S de Vries; F Groenendaal Journal: J Perinatol Date: 2016-08-18 Impact factor: 2.521
Authors: Breda C Hayes; Elaine Doherty; Andrea Grehan; Cathy Madigan; Cliona McGarvey; Siobhan Mulvany; Tom G Matthews; Mary D King Journal: Eur J Pediatr Date: 2017-10-24 Impact factor: 3.183
Authors: Cally J Tann; Margaret Nakakeeto; Barbara A Willey; Margaret Sewegaba; Emily L Webb; Ibby Oke; Emmanuel Derek Mutuuza; Donald Peebles; Margaret Musoke; Kathryn A Harris; Neil J Sebire; Nigel Klein; Jennifer J Kurinczuk; Alison M Elliott; Nicola J Robertson Journal: Arch Dis Child Fetal Neonatal Ed Date: 2017-08-05 Impact factor: 5.747
Authors: Cally J Tann; Kathryn A Martinello; Samantha Sadoo; Joy E Lawn; Anna C Seale; Maira Vega-Poblete; Neal J Russell; Carol J Baker; Linda Bartlett; Clare Cutland; Michael G Gravett; Margaret Ip; Kirsty Le Doare; Shabir A Madhi; Craig E Rubens; Samir K Saha; Stephanie Schrag; Ajoke Sobanjo-Ter Meulen; Johan Vekemans; Paul T Heath Journal: Clin Infect Dis Date: 2017-11-06 Impact factor: 9.079