OBJECTIVE: To assess the relationship between placental pathology, pattern of brain injury and neurodevelopmental outcome in term infants with perinatal asphyxia receiving therapeutic hypothermia. STUDY DESIGN: Studies were performed in 76 infants. Death or survival with impairments at 18 to 24 months was used as a composite adverse outcome. Multivariable analysis was performed. RESULTS: Among the 75 infants analyzed, the predominant pattern of brain injury was: no injury (n=27), a white matter/watershed pattern (n=14), basal-ganglia-thalamic injury (n=13) or near-total brain injury (n=21). An adverse outcome was seen in 35 of the 76 infants. Elevated nucleated red blood cells were associated with white matter involvement. Small placental infarcts were more common among infants without brain injury. All other placental abnormalities were not related to both outcome measures. CONCLUSION: In our population of term infants receiving therapeutic hypothermia, no type of placental pathology was related to extensive brain injury or adverse neurodevelopmental outcome.
OBJECTIVE: To assess the relationship between placental pathology, pattern of brain injury and neurodevelopmental outcome in term infants with perinatal asphyxia receiving therapeutic hypothermia. STUDY DESIGN: Studies were performed in 76 infants. Death or survival with impairments at 18 to 24 months was used as a composite adverse outcome. Multivariable analysis was performed. RESULTS: Among the 75 infants analyzed, the predominant pattern of brain injury was: no injury (n=27), a white matter/watershed pattern (n=14), basal-ganglia-thalamic injury (n=13) or near-total brain injury (n=21). An adverse outcome was seen in 35 of the 76 infants. Elevated nucleated red blood cells were associated with white matter involvement. Small placental infarcts were more common among infants without brain injury. All other placental abnormalities were not related to both outcome measures. CONCLUSION: In our population of term infants receiving therapeutic hypothermia, no type of placental pathology was related to extensive brain injury or adverse neurodevelopmental outcome.
Authors: Steven P Miller; Vijay Ramaswamy; David Michelson; A James Barkovich; Barbara Holshouser; Nathaniel Wycliffe; David V Glidden; Douglas Deming; J Colin Partridge; Yvonne W Wu; Stephen Ashwal; Donna M Ferriero Journal: J Pediatr Date: 2005-04 Impact factor: 4.406
Authors: Monique W M de Laat; Arie Franx; Michiel L Bots; Gerard H A Visser; Peter G J Nikkels Journal: Obstet Gynecol Date: 2006-05 Impact factor: 7.661
Authors: Denise G M McDonald; Peter Kelehan; Joseph B McMenamin; Winifred A Gorman; David Madden; Iqdam N Tobbia; Eoghan E Mooney Journal: Hum Pathol Date: 2004-07 Impact factor: 3.466
Authors: Johanna C Harteman; Peter G J Nikkels; Manon J N L Benders; Anneke Kwee; Floris Groenendaal; Linda S de Vries Journal: J Pediatr Date: 2013-07-25 Impact factor: 4.406
Authors: Johanna C Harteman; Floris Groenendaal; Mona C Toet; Manon Jnl Benders; Ingrid C Van Haastert; Rutger Aj Nievelstein; Corine Koopman-Esseboom; Linda S de Vries Journal: Dev Med Child Neurol Date: 2013-04-01 Impact factor: 5.449
Authors: Rebecca L Linn; Jessica Kiley; Lucy Minturn; Michael K Fritsch; Todd Dejulio; Emily Rostlund; Linda M Ernst Journal: Pediatr Dev Pathol Date: 2013-07-30
Authors: Thomas Alderliesten; Peter G J Nikkels; Manon J N L Benders; Linda S de Vries; Floris Groenendaal Journal: Arch Dis Child Fetal Neonatal Ed Date: 2012-11-21 Impact factor: 5.747
Authors: Breda C Hayes; Sharon Cooley; Jennifer Donnelly; Elaine Doherty; Andrea Grehan; Cathy Madigan; Cliona McGarvey; Siobhan Mulvany; Stephanie Ryan; John Gillian; Michael P Geary; Tom G Matthews; Mary D King Journal: Arch Dis Child Fetal Neonatal Ed Date: 2012-07-12 Impact factor: 5.747
Authors: Jessica L Wisnowski; Stefan Bluml; Ashok Panigrahy; Amit M Mathur; Jeffrey Berman; Ping-Sun Keven Chen; James Dix; Trevor Flynn; Stanley Fricke; Seth D Friedman; Hayden W Head; Chang Y Ho; Beth Kline-Fath; Michael Oveson; Richard Patterson; Sumit Pruthi; Nancy Rollins; Yanerys M Ramos; John Rampton; Jerome Rusin; Dennis W Shaw; Mark Smith; Jean Tkach; Shreyas Vasanawala; Arastoo Vossough; Matthew T Whitehead; Duan Xu; Kristen Yeom; Bryan Comstock; Patrick J Heagerty; Sandra E Juul; Yvonne W Wu; Robert C McKinstry Journal: BMJ Open Date: 2021-04-22 Impact factor: 2.692