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Literature DB >> 22775474

Geranylphenazinediol, an acetylcholinesterase inhibitor produced by a Streptomyces species.

Birgit Ohlendorf¹, Dirk Schulz, Arlette Erhard, Kerstin Nagel, Johannes F Imhoff.

Abstract

Geranylphenazinediol (1), a new phenazine natural product, was produced by the Streptomyces sp. strain LB173, which was isolated from a marine sediment sample. The structure was established by analysis of NMR and MS data. 1 inhibited the enzyme acetylcholinesterase in the low micromolar range and showed weak antibacterial activity. In order to get a more detailed picture of the activity profile of 1, its inhibitory potential was compared to that of related structures.

Entities: Chemical Species

Mesh：

Substances：

Year: 2012 PMID： 22775474 DOI： 10.1021/np2009626

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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Cited

18 in total

1. Acetylcholinesterase inhibitors from a marine fungus Talaromyces sp. strain LF458.

Authors: Bin Wu; Birgit Ohlendorf; Vanessa Oesker; Jutta Wiese; Susann Malien; Rolf Schmaljohann; Johannes F Imhoff
Journal: Mar Biotechnol (NY) Date: 2014-08-10 Impact factor: 3.619

2. Identification of novel endophenaside antibiotics produced by Kitasatospora sp. MBT66.

Authors: Changsheng Wu; Gilles P van Wezel; Young Hae Choi
Journal: J Antibiot (Tokyo) Date: 2015-02-18 Impact factor: 2.649

Review 3. Antimicrobial compounds from marine actinomycetes.

Authors: Cong Wang; Yuanyu Lu; Shugeng Cao
Journal: Arch Pharm Res Date: 2020-07-20 Impact factor: 4.946

Review 4. Bacterial terpenome.

Authors: Jeffrey D Rudolf; Tyler A Alsup; Baofu Xu; Zining Li
Journal: Nat Prod Rep Date: 2021-05-26 Impact factor: 15.111

5. Lindgomycin, an Unusual Antibiotic Polyketide from a Marine Fungus of the Lindgomycetaceae.

Authors: Bin Wu; Jutta Wiese; Antje Labes; Annemarie Kramer; Rolf Schmaljohann; Johannes F Imhoff
Journal: Mar Drugs Date: 2015-07-27 Impact factor: 5.118

6. Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments.

Authors: Bin Wu; Jutta Wiese; Rolf Schmaljohann; Johannes F Imhoff
Journal: Mar Drugs Date: 2016-11-02 Impact factor: 5.118

Geranylphenazinediol, an acetylcholinesterase inhibitor produced by a Streptomyces species.

1. Acetylcholinesterase inhibitors from a marine fungus Talaromyces sp. strain LF458.

2. Identification of novel endophenaside antibiotics produced by Kitasatospora sp. MBT66.

Review 3. Antimicrobial compounds from marine actinomycetes.

Review 4. Bacterial terpenome.

5. Lindgomycin, an Unusual Antibiotic Polyketide from a Marine Fungus of the Lindgomycetaceae.

6. Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments.

7. StreptomeDB: a resource for natural compounds isolated from Streptomyces species.

8. Isolation, structure elucidation and total synthesis of lajollamide A from the marine fungus Asteromyces cruciatus.

9. Two new antibiotic pyridones produced by a marine fungus, Trichoderma sp. strain MF106.

10. Spirocyclic drimanes from the marine fungus Stachybotrys sp. strain MF347.