PURPOSE: To review the incidence, histopathological features and clinical outcomes of patients with incidental prostate cancer (CaP) found in cystoprostatectomy specimens (CP) excised for bladder cancer and to determine whether these prostate cancers could affect the follow-up strategy. PATIENTS AND METHODS: We retrospectively reviewed the records of 110 patients who underwent CP for bladder cancer (1998-2011) at our institution. CaP grade, stage, volume and surgical margin status were recorded. Prostatic involvement by bladder tumour or carcinoma in situ (CIS) was studied. Pre-operative prostate assessment and follow-up in those diagnosed with incidental CaP were analysed. RESULTS: Incidental CaP was identified in 35 patients (32.5%), 4 with prostatic PIN alone and 2 patients with diagnoses of CaP prior to cystectomy were excluded from study. Of the CaP cases, 28.5% had clinically significant disease: 5 with Gleason score 7, 2 with Gleason score 9, who also had extracapsular invasion of tumour, and three with positive surgical margins. All patients were pN0 for CaP. Of the 108 patients, 16.5% had prostatic urethral involvement with CIS or TCC. In the subgroup of patients with the incidentally diagnosed CaP who developed local recurrence of bladder tumour and/or metastatic disease, none originated from their CaP. CONCLUSION: The majority of incidental CaP in CP specimens are organ confined and do not influence oncological outcome. The prognosis of such patients is primarily determined by bladder cancer. Our findings support previous reports and autopsy studies elsewhere.
PURPOSE: To review the incidence, histopathological features and clinical outcomes of patients with incidental prostate cancer (CaP) found in cystoprostatectomy specimens (CP) excised for bladder cancer and to determine whether these prostate cancers could affect the follow-up strategy. PATIENTS AND METHODS: We retrospectively reviewed the records of 110 patients who underwent CP for bladder cancer (1998-2011) at our institution. CaP grade, stage, volume and surgical margin status were recorded. Prostatic involvement by bladder tumour or carcinoma in situ (CIS) was studied. Pre-operative prostate assessment and follow-up in those diagnosed with incidental CaP were analysed. RESULTS: Incidental CaP was identified in 35 patients (32.5%), 4 with prostatic PIN alone and 2 patients with diagnoses of CaP prior to cystectomy were excluded from study. Of the CaP cases, 28.5% had clinically significant disease: 5 with Gleason score 7, 2 with Gleason score 9, who also had extracapsular invasion of tumour, and three with positive surgical margins. All patients were pN0 for CaP. Of the 108 patients, 16.5% had prostatic urethral involvement with CIS or TCC. In the subgroup of patients with the incidentally diagnosed CaP who developed local recurrence of bladder tumour and/or metastatic disease, none originated from their CaP. CONCLUSION: The majority of incidental CaP in CP specimens are organ confined and do not influence oncological outcome. The prognosis of such patients is primarily determined by bladder cancer. Our findings support previous reports and autopsy studies elsewhere.
Authors: Nicolas Barry Delongchamps; Kaili Mao; Hang Theng; Marc Zerbib; Bernard Debré; Michaël Peyromaure Journal: Eur Urol Date: 2005-08-02 Impact factor: 20.096
Authors: Monica P Revelo; Michael S Cookson; Sam S Chang; M Frances Shook; Joseph A Smith; Scott B Shappell Journal: J Urol Date: 2004-02 Impact factor: 7.450
Authors: C Wetterauer; M Weibel; J R Gsponer; T Vlajnic; T Zellweger; S Bütikofer; G Müller; H Püschel; A Bachmann; T C Gasser; L Bubendorf; C A Rentsch Journal: Virchows Arch Date: 2014-10-01 Impact factor: 4.064
Authors: Antonio Lopez-Beltran; Liang Cheng; Francesco Montorsi; Maria Scarpelli; Maria R Raspollini; Rodolfo Montironi Journal: Nat Rev Urol Date: 2017-08-16 Impact factor: 14.432
Authors: Christian Thomas; Alexander Giesswein; Michael Hainz; Raimund Stein; Peter Rubenwolf; Frederik C Roos; Andreas Neisius; Sebastian Nestler; Christian Hampel; Wolfgang Jäger; Christoph Wiesner; Joachim W Thüroff Journal: Int Urol Nephrol Date: 2015-09-16 Impact factor: 2.370
Authors: Pietro Pepe; Filippo Fraggetta; Antonio Galia; Paolo Panella; Michele Pennisi; Maurizio Colecchia; Francesco Aragona Journal: Int Urol Nephrol Date: 2014-02-01 Impact factor: 2.370
Authors: In-Chang Cho; Jeong Eun Kim; Sung Han Kim; Jae Young Joung; Ho Kyung Seo; Jinsoo Chung; Weon Seo Park; Kang Hyun Lee Journal: Prostate Int Date: 2015-04-07