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Literature DB >> 22771943

A conserved role for intragenic DNA methylation in alternative pre-mRNA splicing.

Abstract

DNA methylome analysis in a variety of species has revealed elevated 5-methylcytosine at exons relative to introns. These associations raised the possibility that intragenic DNA methylation aids the spliceosome in the process of exon definition. Here, I highlight recent genome-wide associations and direct evidence linking DNA methylation to pre-mRNA splicing.

Entities: Chemical

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Year: 2012 PMID： 22771943 PMCID： PMC3616078 DOI： 10.4161/trns.19816

Source DB: PubMed Journal: Transcription ISSN： 2154-1272

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