Literature DB >> 22771535

Epithelial-to-mesenchymal transition and cancer stem(-like) cells in head and neck squamous cell carcinoma.

Chao Chen1, Miriam Zimmermann, Inge Tinhofer, Andreas M Kaufmann, Andreas E Albers.   

Abstract

Head and neck squamous cell carcinoma (HNSCC) is the 6th commonest cancer worldwide. Relapse, thought to involve cancer stem(-like) cells (CSCs), and the development of metastases are common and survival rates remain low. Epithelial-to-mesenchymal transition (EMT) is a key event in metastasis and increasing evidence suggests a link between EMT and CSCs. MicroRNAs regulate multiple cellular processes including EMT and have been implicated in a CSC phenotype. This review aims to highlight key events that are involved in EMT, discusses their relevance in HNSCC progression and metastasis and explores the possibility of targeting EMT as a novel therapy in HNSCC.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Cancer stem(-like) cells; Epithelial-to-mesenchymal transition; HNSCC; Metastasis; MicroRNA; Therapeutic target regulation

Mesh：

Substances：

Year:  2012        PMID： 22771535     DOI： 10.1016/j.canlet.2012.06.013

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  39 in total

1.  CD271 Confers an Invasive and Metastatic Phenotype of Head and Neck Squamous Cell Carcinoma through the Upregulation of Slug.

Authors:  Man Ki Chung; Young Ho Jung; Joon Kyoo Lee; Soo Youn Cho; Oihana Murillo-Sauca; Ravindra Uppaluri; June Ho Shin; John B Sunwoo
Journal:  Clin Cancer Res       Date:  2017-12-05       Impact factor: 12.531

2.  Evaluation of the Cell Invasion and Migration Process: A Comparison of the Video Microscope-based Scratch Wound Assay and the Boyden Chamber Assay.

Authors:  Jean-Baptiste Guy; Sophie Espenel; Alexis Vallard; Priscillia Battiston-Montagne; Anne-Sophie Wozny; Dominique Ardail; Gersende Alphonse; Chloé Rancoule; Claire Rodriguez-Lafrasse; Nicolas Magne
Journal:  J Vis Exp       Date:  2017-11-17       Impact factor: 1.355

3.  Epithelial-mesenchymal transition (EMT) markers have prognostic impact in multiple primary oral squamous cell carcinoma.

Authors:  Sabrina Daniela da Silva; Grégoire B Morand; Faisal A Alobaid; Michael P Hier; Alex M Mlynarek; Moulay A Alaoui-Jamali; Luiz Paulo Kowalski
Journal:  Clin Exp Metastasis       Date:  2014-11-30       Impact factor: 5.150

4.  Cancer as the Disintegration of Robustness: Population-Level Variance in Gene Expression Identifies Key Differences Between Tobacco- and HPV-Associated Oropharyngeal Carcinogenesis.

Authors:  Miriam M Ben-Dayan; Thomas MacCarthy; Nicolas F Schlecht; Thomas J Belbin; Geoffrey Childs; Richard V Smith; Michael B Prystowsky; Aviv Bergman
Journal:  Arch Pathol Lab Med       Date:  2015-07-01       Impact factor: 5.534

Review 5.  Concise review: custodians of the transcriptome: how microRNAs guard stemness in squamous epithelia.

Authors:  Matthew S Ning; Thomas Andl
Journal:  Stem Cells       Date:  2015-04       Impact factor: 6.277

6.  Prognostic significance of ALDH1A1-positive cancer stem cells in patients with locally advanced, metastasized head and neck squamous cell carcinoma.

Authors:  Xu Qian; Steffen Wagner; Chenming Ma; Annekatrin Coordes; Julia Gekeler; Jens P Klussmann; Michael Hummel; Andreas M Kaufmann; Andreas E Albers
Journal:  J Cancer Res Clin Oncol       Date:  2014-04-27       Impact factor: 4.553

7.  Oxidative stress, epigenetics, and cancer stem cells in arsenic carcinogenesis and prevention.

Authors:  Lingzhi Li; Fei Chen
Journal:  Curr Pharmacol Rep       Date:  2016-01-23

8.  Pituitary tumor-transforming gene 1 (PTTG1) is overexpressed in oral squamous cell carcinoma (OSCC) and promotes migration, invasion and epithelial-mesenchymal transition (EMT) in SCC15 cells.

Authors:  Enjiao Zhang; Shuang Liu; Zhongfei Xu; Shaohui Huang; Xuexin Tan; Changfu Sun; Li Lu
Journal:  Tumour Biol       Date:  2014-05-31

9.  Comparative secretome analysis of epithelial and mesenchymal subpopulations of head and neck squamous cell carcinoma identifies S100A4 as a potential therapeutic target.

Authors:  Kati Rasanen; Sira Sriswasdi; Alexander Valiga; Hsin-Yao Tang; Gao Zhang; Michela Perego; Rajasekharan Somasundaram; Ling Li; Kaye Speicher; Andres J Klein-Szanto; Devraj Basu; Anil K Rustgi; David W Speicher; Meenhard Herlyn
Journal:  Mol Cell Proteomics       Date:  2013-09-13       Impact factor: 5.911

Review 10.  [Cancer stem cell phenotypes and miRNA: therapeutic targets in head and neck squamous cell carcinoma].

Authors:  A Coordes; S Zhifeng; V Sangvatanakul; X Qian; M Lenarz; A M Kaufmann; A E Albers
Journal:  HNO       Date:  2014-12       Impact factor: 1.284
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