Oxidative stress, epigenetics, and cancer stem cells in arsenic carcinogenesis and prevention.

The carcinogenic role of arsenic has been extensively studied for more than half century. How arsenic causes human cancer, however, remains to be fully elucidated. In this brief review, we focus our attentions on the most recent discoveries by us and others on the capabilities of arsenic in inducing generation of reactive oxygen species (ROS), expression of microRNAs (miRNAs) and the generation of the cancer stem cells. We believe that these new understandings on the mechanisms of arsenic-induced carcinogenesis will shed light on the prevention and treatment of human cancers resulted from environmental or occupational arsenic exposure. Furthermore, these latest findings on arsenic-induced cellular responses will also have an important impact on the investigation of the carcinogenic effects of other environmental or occupational carcinogens or hazards.