Literature DB >> 2276457

A general kinetic equation for multihydronic state reactions and rapid procedures for parameter evaluation.

S M Brocklehurst1, C M Topham, K Brocklehurst.   

Abstract

Mesh：

Year:  1990        PMID： 2276457     DOI： 10.1042/bst0180598

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


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  14 in total

1.  Biochemical and X-ray crystallographic studies on shikimate kinase: the important structural role of the P-loop lysine.

Authors:  T Krell; J Maclean; D J Boam; A Cooper; M Resmini; K Brocklehurst; S M Kelly; N C Price; A J Lapthorn; J R Coggins
Journal:  Protein Sci       Date:  2001-06       Impact factor: 6.725

2.  Evaluation of hydrogen-bonding and enantiomeric P2-S2 hydrophobic contacts in dynamic aspects of molecular recognition by papain.

Authors:  M Patel; I S Kayani; W Templeton; G W Mellor; E W Thomas; K Brocklehurst
Journal:  Biochem J       Date:  1992-11-01       Impact factor: 3.857

3.  Evidence for 'lock and key' character in an anti-phosphonate hydrolytic antibody catalytic site augmented by non-reaction centre recognition: variation in substrate selectivity between an anti-phosphonate antibody, an anti-phosphate antibody and two hydrolytic enzymes.

Authors:  Sanjiv Sonkaria; Guillaume Boucher; José Flórez-Olvarez; Bilal Said; Syeed Hussain; Elizabeth L Ostler; Sheraz Gul; Emrys W Thomas; Marina Resmini; Gerard Gallacher; Keith Brocklehurst
Journal:  Biochem J       Date:  2004-07-01       Impact factor: 3.857

4.  Improvement in hydrolytic antibody activity by change in haptenic structure from phosphate to phosphonate with retention of a common leaving-group determinant: evidence for the 'flexibility' hypothesis.

Authors:  Sheraz Gul; Sanjiv Sonkaria; Surapong Pinitglang; José Florez-Alvarez; Syeed Hussain; Emrys W Thomas; Elizabeth L Ostler; Gerard Gallacher; Marina Resmini; Keith Brocklehurst
Journal:  Biochem J       Date:  2003-12-15       Impact factor: 3.857

5.  Clarification of the pH-dependent kinetic behaviour of papain by using reactivity probes and analysis of alkylation and catalysed acylation reactions in terms of multihydronic state models: implications for electrostatics calculations and interpretation of the consequences of site-specific mutations such as Asp-158-Asn and Asp-158-Glu.

Authors:  G W Mellor; M Patel; E W Thomas; K Brocklehurst
Journal:  Biochem J       Date:  1993-08-15       Impact factor: 3.857

6.  Characterization of retinaldehyde dehydrogenase 3.

Authors:  Caroline E Graham; Keith Brocklehurst; Richard W Pickersgill; Martin J Warren
Journal:  Biochem J       Date:  2006-02-15       Impact factor: 3.857

7.  Ionization characteristics and chemical influences of aspartic acid residue 158 of papain and caricain determined by structure-related kinetic and computational techniques: multiple electrostatic modulators of active-centre chemistry.

Authors:  M A Noble; S Gul; C S Verma; K Brocklehurst
Journal:  Biochem J       Date:  2000-11-01       Impact factor: 3.857

8.  Variation in the pH-dependent pre-steady-state and steady-state kinetic characteristics of cysteine-proteinase mechanism: evidence for electrostatic modulation of catalytic-site function by the neighbouring carboxylate anion.

Authors:  Syeed Hussain; Surapong Pinitglang; Tamara S F Bailey; James D Reid; Michael A Noble; Marina Resmini; Emrys W Thomas; Richard B Greaves; Chandra S Verma; Keith Brocklehurst
Journal:  Biochem J       Date:  2003-06-15       Impact factor: 3.857

9.  Ionization characteristics of the Cys-25/His-159 interactive system and of the modulatory group of papain: resolution of ambiguity by electronic perturbation of the quasi-2-mercaptopyridine leaving group in a new pyrimidyl disulphide reactivity probe.

Authors:  G W Mellor; E W Thomas; C M Topham; K Brocklehurst
Journal:  Biochem J       Date:  1993-02-15       Impact factor: 3.857

10.  Catalytic-site characteristics of the porcine calpain II 80 kDa/18 kDa heterodimer revealed by selective reaction of its essential thiol group with two-hydronic-state time-dependent inhibitors: evidence for a catalytic site Cys/His interactive system and an ionizing modulatory group.

Authors:  G W Mellor; S K Sreedharan; D Kowlessur; E W Thomas; K Brocklehurst
Journal:  Biochem J       Date:  1993-02-15       Impact factor: 3.857
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