BACKGROUND: Recent preventive strategies for patients with cognitive impairment include the identification of modifiable somatic risk factors like vitamin D deficiency. METHODS: A systematic literature research and meta-analysis were conducted to assess the association of cognitive impairment and vitamin D deficiency. RESULTS: Data from cross-sectional and longitudinal studies suggest an association between cognitive impairment and vitamin D deficiency. Meta-analysis of 5 cross-sectional and 2 longitudinal studies comprising 7,688 participants showed an increased risk of cognitive impairment in those with low vitamin D compared with normal vitamin D (OR 2.39, 95% CI 1.91-3.00; p < 0.0001). CONCLUSIONS: Methodological limitations of these studies comprise heterogeneity of study populations, different forms of cognitive assessment, the problem of reverse causality, different definitions of vitamin D deficiency and inconsistent control for confounders. As the value of vitamin D substitution in cognitive impairment remains doubtful, a long-time major placebo-controlled randomized trial of vitamin D supplementation in participants with mild cognitive impairment (MCI) should be started.
BACKGROUND: Recent preventive strategies for patients with cognitive impairment include the identification of modifiable somatic risk factors like vitamin D deficiency. METHODS: A systematic literature research and meta-analysis were conducted to assess the association of cognitive impairment and vitamin D deficiency. RESULTS: Data from cross-sectional and longitudinal studies suggest an association between cognitive impairment and vitamin D deficiency. Meta-analysis of 5 cross-sectional and 2 longitudinal studies comprising 7,688 participants showed an increased risk of cognitive impairment in those with low vitamin D compared with normal vitamin D (OR 2.39, 95% CI 1.91-3.00; p < 0.0001). CONCLUSIONS: Methodological limitations of these studies comprise heterogeneity of study populations, different forms of cognitive assessment, the problem of reverse causality, different definitions of vitamin D deficiency and inconsistent control for confounders. As the value of vitamin D substitution in cognitive impairment remains doubtful, a long-time major placebo-controlled randomized trial of vitamin D supplementation in participants with mild cognitive impairment (MCI) should be started.
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Authors: Laurel Kilpatrick; Denise K Houston; Valerie K Wilson; James Lovato; Hilsa N Ayonayon; Jane A Cauley; Tamara Harris; Eleanor M Simonsick; Kristine Yaffe; Stephen B Kritchevsky; Kaycee M Sink Journal: J Nutr Gerontol Geriatr Date: 2018-03-05