Literature DB >> 22751036

Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities.

Ana M M Oliveira1, Thekla J Hemstedt, Hilmar Bading.   

Abstract

Cognitive abilities decline in normal aging, yet the underlying molecular mechanisms are poorly understood. We found that aging was associated with a decrease in the expression of the DNA methyltransferase Dnmt3a2 in the hippocampus and that rescuing Dnmt3a2 levels restored cognitive functions. Moreover, we found that Dnmt3a2 is an activity-regulated immediate early gene that is partly dependent on nuclear calcium signaling and that hippocampal Dnmt3a2 levels determine cognitive abilities in both young adult and aged mice.

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Year:  2012        PMID： 22751036     DOI： 10.1038/nn.3151

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  19 in total

1.  Differential inheritance modes of DNA methylation between euchromatic and heterochromatic DNA sequences in ageing fetal bovine fibroblasts.

Authors:  Y K Kang; D B Koo; J S Park; Y H Choi; K K Lee; Y M Han
Journal:  FEBS Lett       Date:  2001-06-01       Impact factor: 4.124

2.  Age related changes in 5-methylcytosine content in human peripheral leukocytes and placentas: an HPLC-based study.

Authors:  C Fuke; M Shimabukuro; A Petronis; J Sugimoto; T Oda; K Miura; T Miyazaki; C Ogura; Y Okazaki; Y Jinno
Journal:  Ann Hum Genet       Date:  2004-05       Impact factor: 1.670

3.  Covalent modification of DNA regulates memory formation.

Authors:  Courtney A Miller; J David Sweatt
Journal:  Neuron       Date:  2007-03-15       Impact factor: 17.173

4.  Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons.

Authors:  Jian Feng; Yu Zhou; Susan L Campbell; Thuc Le; En Li; J David Sweatt; Alcino J Silva; Guoping Fan
Journal:  Nat Neurosci       Date:  2010-03-14       Impact factor: 24.884

5.  Stimulation of protein tyrosine phosphorylation by NMDA receptor activation.

Authors:  H Bading; M E Greenberg
Journal:  Science       Date:  1991-08-23       Impact factor: 47.728

6.  Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression.

Authors:  G E Hardingham; S Chawla; C M Johnson; H Bading
Journal:  Nature       Date:  1997-01-16       Impact factor: 49.962

7.  Epigenetic alterations are critical for fear memory consolidation and synaptic plasticity in the lateral amygdala.

Authors:  Melissa S Monsey; Kristie T Ota; Irene F Akingbade; Ellie S Hong; Glenn E Schafe
Journal:  PLoS One       Date:  2011-05-20       Impact factor: 3.240

8.  A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation.

Authors:  Taiping Chen; Yoshihide Ueda; Shaoping Xie; En Li
Journal:  J Biol Chem       Date:  2002-07-22       Impact factor: 5.157

9.  Nuclear calcium signaling controls expression of a large gene pool: identification of a gene program for acquired neuroprotection induced by synaptic activity.

Authors:  Sheng-Jia Zhang; Ming Zou; Li Lu; David Lau; Désirée A W Ditzel; Celine Delucinge-Vivier; Yoshinori Aso; Patrick Descombes; Hilmar Bading
Journal:  PLoS Genet       Date:  2009-08-14       Impact factor: 5.917

10.  MeCP2, a key contributor to neurological disease, activates and represses transcription.

Authors:  Maria Chahrour; Sung Yun Jung; Chad Shaw; Xiaobo Zhou; Stephen T C Wong; Jun Qin; Huda Y Zoghbi
Journal:  Science       Date:  2008-05-30       Impact factor: 47.728
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  112 in total

1.  Dnmt3a2: a hub for enhancing cognitive functions.

Authors:  A M M Oliveira; T J Hemstedt; H E Freitag; H Bading
Journal:  Mol Psychiatry       Date:  2015-11-24       Impact factor: 15.992

Review 2.  DNA modifications and neurological disorders.

Authors:  Yi-Lan Weng; Ran An; Jaehoon Shin; Hongjun Song; Guo-li Ming
Journal:  Neurotherapeutics       Date:  2013-10       Impact factor: 7.620

Review 3.  Prospects for the development of epigenetic drugs for CNS conditions.

Authors:  Moshe Szyf
Journal:  Nat Rev Drug Discov       Date:  2015-05-22       Impact factor: 84.694

Review 4.  Chemobrain: a critical review and causal hypothesis of link between cytokines and epigenetic reprogramming associated with chemotherapy.

Authors:  Xiao-Min Wang; Brian Walitt; Leorey Saligan; Agnes F Y Tiwari; Chi Wai Cheung; Zhang-Jin Zhang
Journal:  Cytokine       Date:  2015-01-05       Impact factor: 3.861

Review 5.  Diverse and dynamic DNA modifications in brain and diseases.

Authors:  Matthew J Armstrong; Yulin Jin; Emily G Allen; Peng Jin
Journal:  Hum Mol Genet       Date:  2019-11-21       Impact factor: 6.150

Review 6.  Epigenetic regulation of memory formation and maintenance.

Authors:  Iva B Zovkic; Mikael C Guzman-Karlsson; J David Sweatt
Journal:  Learn Mem       Date:  2013-01-15       Impact factor: 2.460

7.  Dnmt3a2 in the Nucleus Accumbens Shell Is Required for Reinstatement of Cocaine Seeking.

Authors:  Nazzareno Cannella; Ana M M Oliveira; Thekla Hemstedt; Thomas Lissek; Elena Buechler; Hilmar Bading; Rainer Spanagel
Journal:  J Neurosci       Date:  2018-07-20       Impact factor: 6.167

Review 8.  When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron.

Authors:  Johannes C M Schlachetzki; Tomohisa Toda; Jerome Mertens
Journal:  Exp Gerontol       Date:  2020-02-14       Impact factor: 4.032

9.  Selective role for DNMT3a in learning and memory.

Authors:  Michael J Morris; Megumi Adachi; Elisa S Na; Lisa M Monteggia
Journal:  Neurobiol Learn Mem       Date:  2014-06-14       Impact factor: 2.877

10.  Age-related changes in Egr1 transcription and DNA methylation within the hippocampus.

Authors:  M R Penner; R R Parrish; L T Hoang; T L Roth; F D Lubin; C A Barnes
Journal:  Hippocampus       Date:  2016-04-04       Impact factor: 3.899
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