Literature DB >> 2274577

The dihydrofolate reductase-thymidylate synthetase gene in the drug resistance of malaria parasites.

J E Hyde1.   

Abstract

Resistance to antifolate drugs such as pyrimethamine is widespread among malaria parasites of the most pathogenic species Plasmodium falciparum. These drugs inhibit the dihydrofolate reductase activity of the dihydrofolate reductase-thymidylate synthetase (DHFR-TS) bifunctional enzyme. This review examines work done to characterize the enzyme, the cloning of plasmodial DHFR-TS genes, chromosomal mapping studies of these genes by pulsed-field gel electrophoresis, and the structural insights into the mechanism of drug resistance that have been gained by comparing genes from drug-sensitive parasites with those from drug-resistant strains that have arisen in the field or after experimental induction.

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Year:  1990        PMID： 2274577     DOI： 10.1016/0163-7258(90)90017-v

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  31 in total

1.  Molecular determination of point mutation haplotypes in the dihydrofolate reductase and dihydropteroate synthase of Plasmodium falciparum in three districts of northern Tanzania.

Authors:  Richard J Pearce; Chris Drakeley; Daniel Chandramohan; Frank Mosha; Cally Roper
Journal:  Antimicrob Agents Chemother       Date:  2003-04       Impact factor: 5.191

2.  Genetics of mefloquine resistance in the rodent malaria parasite Plasmodium chabaudi.

Authors:  Pedro V L Cravo; Jane M-R Carlton; Paul Hunt; Laura Bisoni; Rose Ann Padua; David Walliker
Journal:  Antimicrob Agents Chemother       Date:  2003-02       Impact factor: 5.191

3.  Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate drug pressure.

Authors:  Edwin Ochong; David J Bell; David J Johnson; Umberto D'Alessandro; Modest Mulenga; Sant Muangnoicharoen; Jean-Pierre Van Geertruyden; Peter A Winstanley; Patrick G Bray; Stephen A Ward; Andrew Owen
Journal:  Antimicrob Agents Chemother       Date:  2008-08-25       Impact factor: 5.191

4.  Effects of extracts from Echinacea purpurea (L) MOENCH on mice infected with different strains of Toxoplasma gondii.

Authors:  Arquimedes Gasparotto Junior; Maria Luiza Antonio Cosmo; Michelle de Paula Reis; Pamela Secundo Dos Santos; Daniela Dib Gonçalves; Francielly Mourão Gasparotto; Italmar Teodorico Navarro; Emerson Luiz Botelho Lourenço
Journal:  Parasitol Res       Date:  2016-06-09       Impact factor: 2.289

5.  Molecular basis of in vivo resistance to sulfadoxine-pyrimethamine in African adult patients infected with Plasmodium falciparum malaria parasites.

Authors:  L K Basco; R Tahar; P Ringwald
Journal:  Antimicrob Agents Chemother       Date:  1998-07       Impact factor: 5.191

6.  Malaria cure with sulphadoxine/pyrimethamine combination in 12 semi-immune adults from West-Central Africa with high rates of point mutations in Plasmodium falciparum dhfr and dhps genes.

Authors:  Pedro J Berzosa; Sabino Puente; Agustìn Benito
Journal:  Parasitol Res       Date:  2005-07-13       Impact factor: 2.289

7.  Scaling up of intermittent preventive treatment of malaria in pregnancy using sulphadoxine-pyrimethamine: prospects and challenges.

Authors:  Wellington Aghoghovwia Oyibo; Chimere Obiora Agomo
Journal:  Matern Child Health J       Date:  2011-05

8.  In vitro generation of novel pyrimethamine resistance mutations in the Toxoplasma gondii dihydrofolate reductase.

Authors:  M G Reynolds; J Oh; D S Roos
Journal:  Antimicrob Agents Chemother       Date:  2001-04       Impact factor: 5.191

9.  Novel Saccharomyces cerevisiae screen identifies WR99210 analogues that inhibit Mycobacterium tuberculosis dihydrofolate reductase.

Authors:  A'Lissa B Gerum; Jonathan E Ulmer; David P Jacobus; Norman P Jensen; David R Sherman; Carol Hopkins Sibley
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191

10.  Markers of anti-malarial drug resistance in Plasmodium falciparum isolates from Swaziland: identification of pfmdr1-86F in natural parasite isolates.

Authors:  Sabelo V Dlamini; Khalid Beshir; Colin J Sutherland
Journal:  Malar J       Date:  2010-03-03       Impact factor: 2.979
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