Literature DB >> 16012864

Malaria cure with sulphadoxine/pyrimethamine combination in 12 semi-immune adults from West-Central Africa with high rates of point mutations in Plasmodium falciparum dhfr and dhps genes.

Pedro J Berzosa1, Sabino Puente, Agustìn Benito.   

Abstract

We report 12 uncomplicated falciparum-malaria cases from semi-immune people from Central Africa treated with sulfadoxine/pyrimethamine (Fansidar) in a Spanish hospital. We resolved by PCR-RFLP the mutations in dhfr and dhps genes related to resistance to antifolate drugs. The 12 patients presented high frequencies of combined mutations in both genes but they were completely cured after treatment.

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Year:  2005        PMID： 16012864     DOI： 10.1007/s00436-005-1424-5

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.289


  14 in total

1.  Application of a molecular marker for surveillance of chloroquine-resistant falciparum malaria.

Authors:  A Djimdé; O K Doumbo; R W Steketee; C V Plowe
Journal:  Lancet       Date:  2001-09-15       Impact factor: 79.321

2.  Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparum.

Authors:  A M Nzila; E Nduati; E K Mberu; C Hopkins Sibley; S A Monks; P A Winstanley; W M Watkins
Journal:  J Infect Dis       Date:  2000-06-05       Impact factor: 5.226

3.  Plasmodium falciparum: detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion.

Authors:  M T Duraisingh; J Curtis; D C Warhurst
Journal:  Exp Parasitol       Date:  1998-05       Impact factor: 2.011

4.  Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum.

Authors:  A F Cowman; M J Morry; B A Biggs; G A Cross; S J Foote
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

5.  Molecular epidemiology of malaria in Yaounde, Cameroon. VI. Sequence variations in the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene and in vitro resistance to pyrimethamine and cycloguanil.

Authors:  L K Basco; P Ringwald
Journal:  Am J Trop Med Hyg       Date:  2000-02       Impact factor: 2.345

6.  Sequence variations in the genes encoding dihydropteroate synthase and dihydrofolate reductase and clinical response to sulfadoxine-pyrimethamine in patients with acute uncomplicated falciparum malaria.

Authors:  L K Basco; R Tahar; A Keundjian; P Ringwald
Journal:  J Infect Dis       Date:  2000-07-19       Impact factor: 5.226

7.  Towards an understanding of the mechanism of pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenyan parasites.

Authors:  A M Nzila; E K Mberu; J Sulo; H Dayo; P A Winstanley; C H Sibley; W M Watkins
Journal:  Antimicrob Agents Chemother       Date:  2000-04       Impact factor: 5.191

Review 8.  The dihydrofolate reductase-thymidylate synthetase gene in the drug resistance of malaria parasites.

Authors:  J E Hyde
Journal:  Pharmacol Ther       Date:  1990       Impact factor: 12.310

9.  Usefulness of seminested multiplex PCR in surveillance of imported malaria in Spain.

Authors:  J M Rubio; A Benito; P J Berzosa; J Roche; S Puente; M Subirats; R López-Vélez; L García; J Alvar
Journal:  J Clin Microbiol       Date:  1999-10       Impact factor: 5.948

10.  Beyond chloroquine: implications of drug resistance for evaluating malaria therapy efficacy and treatment policy in Africa.

Authors:  P B Bloland; E M Lackritz; P N Kazembe; J B Were; R Steketee; C C Campbell
Journal:  J Infect Dis       Date:  1993-04       Impact factor: 5.226
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  3 in total

1.  Genotypes and in vivo resistance of Plasmodium falciparum isolates in an endemic region of Iran.

Authors:  Aliehsan Heidari; Sabine Dittrich; Tomas Jelinek; Azarmidokht Kheirandish; Kambiz Banihashemi; Hossein Keshavarz
Journal:  Parasitol Res       Date:  2006-09-26       Impact factor: 2.289

2.  Effects of point mutations in Plasmodium falciparum dihydrofolate reductase and dihydropterate synthase genes on clinical outcomes and in vitro susceptibility to sulfadoxine and pyrimethamine.

Authors:  David J Bacon; Doug Tang; Carola Salas; Norma Roncal; Carmen Lucas; Lucia Gerena; Lorena Tapia; A Alejandro Llanos-Cuentas; Coralith Garcia; Lelv Solari; Dennis Kyle; Alan J Magill
Journal:  PLoS One       Date:  2009-08-26       Impact factor: 3.240

3.  Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria.

Authors:  Richard J Pearce; Hirva Pota; Marie-Solange B Evehe; El-Hadj Bâ; Ghyslain Mombo-Ngoma; Allen L Malisa; Rosalynn Ord; Walter Inojosa; Alexandre Matondo; Diadier A Diallo; Wilfred Mbacham; Ingrid V van den Broek; Todd D Swarthout; Asefaw Getachew; Seyoum Dejene; Martin P Grobusch; Fanta Njie; Samuel Dunyo; Margaret Kweku; Seth Owusu-Agyei; Daniel Chandramohan; Maryline Bonnet; Jean-Paul Guthmann; Sian Clarke; Karen I Barnes; Elizabeth Streat; Stark T Katokele; Petrina Uusiku; Chris O Agboghoroma; Olufunmilayo Y Elegba; Badara Cissé; Ishraga E A-Elbasit; Hayder A Giha; S Patrick Kachur; Caroline Lynch; John B Rwakimari; Pascalina Chanda; Moonga Hawela; Brian Sharp; Inbarani Naidoo; Cally Roper
Journal:  PLoS Med       Date:  2009-04-14       Impact factor: 11.069
  3 in total

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