Dynamic asymmetric organocatalysis: cooperative effects of weak interactions and conformational flexibility in asymmetric organocatalysts.

This review describes recent advances by our research group in the design and applications of conformationally flexible guanidine/bisthiourea organocatalysts to facilitate unique bond-forming processes, including retro-free, enantiodivergent, entropy-controlled, and cycle-specific organocatalysis. Special emphasis is placed on the key requirements to attain high selectivity and on functional switching by exploiting the structural flexibility of our organocatalysts.