BACKGROUND: Although physical activity reduces breast cancer risk, issues critical to providing clear public health messages remain to be elucidated. These include the minimum duration and intensity necessary for risk reduction and the optimal time period for occurrence, as well as subgroup effects, particularly with regard to tumor heterogeneity and body size. METHODS: This study investigated the relationship between recreational physical activity (RPA) and breast cancer risk, in addition to characterizing the joint effects of activity level, weight gain, and body size, through use of a population-based sample of 1504 cases (N = 233 in situ, N = 1271 invasive) and 1555 controls (aged 20-98 years) from the Long Island Breast Cancer Study Project, in Long Island, New York. RESULTS: A nonlinear dose-response association was observed between breast cancer risk and RPA during the reproductive period and after menopause. Women in the third quartile of activity experienced the greatest benefit with an approximate 30% risk reduction for reproductive (odds ratio = 0.67; 95% confidence interval = 0.48-0.94) and postmenopausal activity (odds ratio = 0.70; 95% confidence interval = 0.52-0.95). Little to no difference was observed regarding intensity of activity or hormone receptor status. Joint assessment of RPA, weight gain, and body size revealed that women with unfavorable energy balance profiles were at increased breast cancer risk. A significant multiplicative interaction was observed between RPA and adult weight gain (P = .033). CONCLUSIONS: RPA at any intensity level during the reproductive and postmenopausal years have the greatest benefit for reducing breast cancer risk. Substantial postmenopausal weight gain may eliminate the benefits of regular activity.
BACKGROUND: Although physical activity reduces breast cancer risk, issues critical to providing clear public health messages remain to be elucidated. These include the minimum duration and intensity necessary for risk reduction and the optimal time period for occurrence, as well as subgroup effects, particularly with regard to tumor heterogeneity and body size. METHODS: This study investigated the relationship between recreational physical activity (RPA) and breast cancer risk, in addition to characterizing the joint effects of activity level, weight gain, and body size, through use of a population-based sample of 1504 cases (N = 233 in situ, N = 1271 invasive) and 1555 controls (aged 20-98 years) from the Long Island Breast Cancer Study Project, in Long Island, New York. RESULTS: A nonlinear dose-response association was observed between breast cancer risk and RPA during the reproductive period and after menopause. Women in the third quartile of activity experienced the greatest benefit with an approximate 30% risk reduction for reproductive (odds ratio = 0.67; 95% confidence interval = 0.48-0.94) and postmenopausal activity (odds ratio = 0.70; 95% confidence interval = 0.52-0.95). Little to no difference was observed regarding intensity of activity or hormone receptor status. Joint assessment of RPA, weight gain, and body size revealed that women with unfavorable energy balance profiles were at increased breast cancer risk. A significant multiplicative interaction was observed between RPA and adult weight gain (P = .033). CONCLUSIONS: RPA at any intensity level during the reproductive and postmenopausal years have the greatest benefit for reducing breast cancer risk. Substantial postmenopausal weight gain may eliminate the benefits of regular activity.
Authors: A Guerra; C Rego; E Castro; M J Laires; D Silva; S Sinde; C Monteiro; Z Silva; E Lebre; M Bicho Journal: Rev Port Cardiol Date: 2000-11 Impact factor: 1.374
Authors: A Guerra; C Rego; M J Laires; E M Castro; D Silva; C Monteiro; Z Silva; E Lebre; M Bicho Journal: J Sports Med Phys Fitness Date: 2001-12 Impact factor: 1.637
Authors: Marilie D Gammon; Alfred I Neugut; Regina M Santella; Susan L Teitelbaum; Julie A Britton; Mary Beth Terry; Sybil M Eng; Mary S Wolff; Steven D Stellman; Geoffrey C Kabat; Bruce Levin; H Leon Bradlow; Maureen Hatch; Jan Beyea; David Camann; Martin Trent; Ruby T Senie; Gail C Garbowski; Carla Maffeo; Pat Montalvan; Gertrud S Berkowitz; Margaret Kemeny; Marc Citron; Freya Schnabe; Allan Schuss; Steven Hajdu; Vincent Vincguerra; Gwen W Collman; G Iris Obrams Journal: Breast Cancer Res Treat Date: 2002-06 Impact factor: 4.872
Authors: Xiaohong R Yang; Jenny Chang-Claude; Ellen L Goode; Fergus J Couch; Heli Nevanlinna; Roger L Milne; Mia Gaudet; Marjanka K Schmidt; Annegien Broeks; Angela Cox; Peter A Fasching; Rebecca Hein; Amanda B Spurdle; Fiona Blows; Kristy Driver; Dieter Flesch-Janys; Judith Heinz; Peter Sinn; Alina Vrieling; Tuomas Heikkinen; Kristiina Aittomäki; Päivi Heikkilä; Carl Blomqvist; Jolanta Lissowska; Beata Peplonska; Stephen Chanock; Jonine Figueroa; Louise Brinton; Per Hall; Kamila Czene; Keith Humphreys; Hatef Darabi; Jianjun Liu; Laura J Van 't Veer; Flora E van Leeuwen; Irene L Andrulis; Gord Glendon; Julia A Knight; Anna Marie Mulligan; Frances P O'Malley; Nayana Weerasooriya; Esther M John; Matthias W Beckmann; Arndt Hartmann; Sebastian B Weihbrecht; David L Wachter; Sebastian M Jud; Christian R Loehberg; Laura Baglietto; Dallas R English; Graham G Giles; Catriona A McLean; Gianluca Severi; Diether Lambrechts; Thijs Vandorpe; Caroline Weltens; Robert Paridaens; Ann Smeets; Patrick Neven; Hans Wildiers; Xianshu Wang; Janet E Olson; Victoria Cafourek; Zachary Fredericksen; Matthew Kosel; Celine Vachon; Helen E Cramp; Daniel Connley; Simon S Cross; Sabapathy P Balasubramanian; Malcolm W R Reed; Thilo Dörk; Michael Bremer; Andreas Meyer; Johann H Karstens; Aysun Ay; Tjoung-Won Park-Simon; Peter Hillemanns; Jose Ignacio Arias Pérez; Primitiva Menéndez Rodríguez; Pilar Zamora; Javier Benítez; Yon-Dschun Ko; Hans-Peter Fischer; Ute Hamann; Beate Pesch; Thomas Brüning; Christina Justenhoven; Hiltrud Brauch; Diana M Eccles; William J Tapper; Sue M Gerty; Elinor J Sawyer; Ian P Tomlinson; Angela Jones; Michael Kerin; Nicola Miller; Niall McInerney; Hoda Anton-Culver; Argyrios Ziogas; Chen-Yang Shen; Chia-Ni Hsiung; Pei-Ei Wu; Show-Lin Yang; Jyh-Cherng Yu; Shou-Tung Chen; Giu-Cheng Hsu; Christopher A Haiman; Brian E Henderson; Loic Le Marchand; Laurence N Kolonel; Annika Lindblom; Sara Margolin; Anna Jakubowska; Jan Lubiński; Tomasz Huzarski; Tomasz Byrski; Bohdan Górski; Jacek Gronwald; Maartje J Hooning; Antoinette Hollestelle; Ans M W van den Ouweland; Agnes Jager; Mieke Kriege; Madeleine M A Tilanus-Linthorst; Margriet Collée; Shan Wang-Gohrke; Katri Pylkäs; Arja Jukkola-Vuorinen; Kari Mononen; Mervi Grip; Pasi Hirvikoski; Robert Winqvist; Arto Mannermaa; Veli-Matti Kosma; Jaana Kauppinen; Vesa Kataja; Päivi Auvinen; Ylermi Soini; Reijo Sironen; Stig E Bojesen; David Dynnes Ørsted; Diljit Kaur-Knudsen; Henrik Flyger; Børge G Nordestgaard; Helene Holland; Georgia Chenevix-Trench; Siranoush Manoukian; Monica Barile; Paolo Radice; Susan E Hankinson; David J Hunter; Rulla Tamimi; Suleeporn Sangrajrang; Paul Brennan; James McKay; Fabrice Odefrey; Valerie Gaborieau; Peter Devilee; P E A Huijts; R A E M Tollenaar; C Seynaeve; Gillian S Dite; Carmel Apicella; John L Hopper; Fleur Hammet; Helen Tsimiklis; Letitia D Smith; Melissa C Southey; Manjeet K Humphreys; Douglas Easton; Paul Pharoah; Mark E Sherman; Montserrat Garcia-Closas Journal: J Natl Cancer Inst Date: 2010-12-29 Impact factor: 13.506
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