Literature DB >> 22726432

A movie of RNA polymerase II transcription.

Alan C M Cheung1, Patrick Cramer.   

Abstract

We provide here a molecular movie that captures key aspects of RNA polymerase II initiation and elongation. To create the movie, we combined structural snapshots of the initiation-elongation transition and of elongation, including nucleotide addition, translocation, pausing, proofreading, backtracking, arrest, reactivation, and inhibition. The movie reveals open questions about the mechanism of transcription and provides a useful teaching tool.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22726432     DOI： 10.1016/j.cell.2012.06.006

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  47 in total

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3.  RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription.

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Journal:  Cell       Date:  2016-04-07       Impact factor: 41.582

Review 4.  Structural insights into transcription initiation by RNA polymerase II.

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Journal:  Trends Biochem Sci       Date:  2013-10-11       Impact factor: 13.807

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6.  PICking apart Pol II initiation.

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Review 7.  Connecting the dots of RNA-directed DNA methylation in Arabidopsis thaliana.

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8.  Conserved DNA sequence features underlie pervasive RNA polymerase pausing.

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Journal:  Nucleic Acids Res       Date:  2021-05-07       Impact factor: 16.971

9.  RNA polymerase structure, function, regulation, dynamics, fidelity, and roles in gene expression.

Authors:  Maria L Kireeva; Mikhail Kashlev; Zachary F Burton
Journal:  Chem Rev       Date:  2013-11-13       Impact factor: 60.622

10.  The TAF9 C-terminal conserved region domain is required for SAGA and TFIID promoter occupancy to promote transcriptional activation.

Authors:  Malika Saint; Sonal Sawhney; Ishani Sinha; Rana Pratap Singh; Rashmi Dahiya; Anushikha Thakur; Rahul Siddharthan; Krishnamurthy Natarajan
Journal:  Mol Cell Biol       Date:  2014-02-18       Impact factor: 4.272
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