BACKGROUND: The effect of gender on the expression of primary hyperparathyroidism (PHPT) is not well characterized. AIM: We therefore evaluated two Caucasian populations (US and Italian) of men and women with PHPT, matched for age and body mass index (BMI), in a cross-sectional retrospective observational study. METHODS: We studied 74 US (23 men) and 126 Italian (42 men) patients evaluating main biochemical indices of the disease and bone mineral density (BMD) at the spine and proximal femur. RESULTS: Mean serum calcium levels were higher both in Italian men compared to women (11.7 ± 1.22 mg/dl and 11.1 ± 0.83, p<0.01) and in Italian compared to US patients (11.3 ± 1.01 and 10.8 ± 0.58, p<0.001), with similar results for the serum ionized calcium. Mean serum PTH levels were not different either between the genders or between the countries. After controlling for BMI, the mean BMD at both the femoral neck and total hip in females US patients was significantly higher compared with Italian female patients. CONCLUSION: Despite similar levels of circulating PTH, Italian patients have more pronounced effects of the disease as assessed by serum calcium and a more significant cortical involvement in women as assessed by BMD.
BACKGROUND: The effect of gender on the expression of primary hyperparathyroidism (PHPT) is not well characterized. AIM: We therefore evaluated two Caucasian populations (US and Italian) of men and women with PHPT, matched for age and body mass index (BMI), in a cross-sectional retrospective observational study. METHODS: We studied 74 US (23 men) and 126 Italian (42 men) patients evaluating main biochemical indices of the disease and bone mineral density (BMD) at the spine and proximal femur. RESULTS: Mean serum calcium levels were higher both in Italian men compared to women (11.7 ± 1.22 mg/dl and 11.1 ± 0.83, p<0.01) and in Italian compared to US patients (11.3 ± 1.01 and 10.8 ± 0.58, p<0.001), with similar results for the serum ionizedcalcium. Mean serum PTH levels were not different either between the genders or between the countries. After controlling for BMI, the mean BMD at both the femoral neck and total hip in females US patients was significantly higher compared with Italian female patients. CONCLUSION: Despite similar levels of circulating PTH, Italian patients have more pronounced effects of the disease as assessed by serum calcium and a more significant cortical involvement in women as assessed by BMD.
Authors: M Pedrazzoni; G Girasole; F Bertoldo; G Bianchi; C Cepollaro; A Del Puente; S Giannini; S Gonnelli; D Maggio; C Marcocci; S Minisola; E Palummeri; M Rossini; L Sartori; L Sinigaglia Journal: Osteoporos Int Date: 2003-10-03 Impact factor: 4.507
Authors: G Mazzuoli; S Minisola; G Bianchi; M T Pacitti; R Rosso; E Romagnoli; V Carnevale; L Scarnecchia; F S Celi; V Ortore Journal: J Steroid Biochem Mol Biol Date: 1990-11-20 Impact factor: 4.292
Authors: D Sudhaker Rao; Elizabeth A Wallace; Rosella F Antonelli; Gary B Talpos; Mohammed R Ansari; Gordon Jacobsen; George W Divine; A Michael Parfitt Journal: Clin Endocrinol (Oxf) Date: 2003-03 Impact factor: 3.478
Authors: Shonni J Silverberg; Bart L Clarke; Munro Peacock; Francisco Bandeira; Stephanie Boutroy; Natalie E Cusano; David Dempster; E Michael Lewiecki; Jian-Min Liu; Salvatore Minisola; Lars Rejnmark; Barbara C Silva; Marcella D Walker; John P Bilezikian Journal: J Clin Endocrinol Metab Date: 2014-08-27 Impact factor: 5.958
Authors: Özer Makay; Beyza Özçınar; Turgay Şimşek; Cumhur Arıcı; Bülent Güngör; Serdar Özbaş; Tamer Akça; Ali Uğur Emre; Güldeniz Karadeniz Çakmak; Müfide Akçay; Bülent Ünal; Mustafa Girgin; Sadullah Girgin; Semih Görgülü; Atakan Sezer; Adem Karataş; İbrahim Ali Özemir; Nihat Aksakal; Serap Erel; M Ümit Uğurlu; Ali İlker Filiz; Can Atalay; Ali Uzunköy; Uğur Deveci; Çetin Kotan; Gökhan İçöz; Yavuz Kurt; Abut Kebudi; N Zafer Cantürk; Yeşim Erbil; Rumen Pandev; Bahadır M Güllüoğlu Journal: Balkan Med J Date: 2017-01-05 Impact factor: 2.021