Literature DB >> 22714736

Common genetic variants in the microRNA biogenesis pathway are not associated with breast cancer risk in Asian women.

Hyuna Sung1, Ben Zhang, Ji-Yeob Choi, Jirong Long, Sue K Park, Keun-Young Yoo, Dong-Young Noh, Sei-Hyun Ahn, Wei Zheng, Daehee Kang.   

Abstract

BACKGROUND: Although the role of miRNA in cancer development and progression has been well established, the association between genetic variants in miRNA biogenesis pathway genes and breast cancer risk has been yet unclear.
METHODS: We analyzed data from two genome-wide association studies conducted in East Asian women including 5,066 cases and 4,337 controls. Among the single-nucleotide polymorphisms (SNP), which were directly genotyped or imputed, we selected 237 SNPs in 32 genes involved in miRNA biogenesis pathway and its regulation.
RESULTS: Although eight SNPs were nominally associated with breast cancer risk in combined samples (P < 0.05), none of them were significant after adjustment for multiple comparisons.
CONCLUSIONS: The common genetic variants in miRNA biogenesis pathway genes may not be associated with breast cancer risk. IMPACT: This study suggests no association between the polymorphisms in miRNA biogenesis pathway genes and breast cancer risk. Studies with large sample size and more genetic variants should be warranted to adequately evaluate the potential association. ©2012 AACR.

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Year:  2012        PMID： 22714736      PMCID： PMC4030374          DOI： 10.1158/1055-9965.EPI-12-0600

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.254


  9 in total

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3.  Common genetic polymorphisms of microRNA biogenesis pathway genes and risk of breast cancer: a case-control study in Korea.

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9.  SNPinfo: integrating GWAS and candidate gene information into functional SNP selection for genetic association studies.

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Journal:  Nucleic Acids Res       Date:  2009-05-05       Impact factor: 16.971
  9 in total
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