Literature DB >> 21636674

MicroRNA processing and binding site polymorphisms are not replicated in the Ovarian Cancer Association Consortium.

Jennifer Permuth-Wey1, Zhihua Chen, Ya-Yu Tsai, Hui-Yi Lin, Y Ann Chen, Jill Barnholtz-Sloan, Michael J Birrer, Stephen J Chanock, Daniel W Cramer, Julie M Cunningham, David Fenstermacher, Brooke L Fridley, Montserrat Garcia-Closas, Simon A Gayther, Aleksandra Gentry-Maharaj, Jesus Gonzalez-Bosquet, Edwin Iversen, Heather Jim, John McLaughlin, Usha Menon, Steven A Narod, Catherine M Phelan, Susan J Ramus, Harvey Risch, Honglin Song, Rebecca Sutphen, Kathryn L Terry, Jonathan Tyrer, Robert A Vierkant, Nicolas Wentzensen, Johnathan M Lancaster, Jin Q Cheng, Andrew Berchuck, Paul D P Pharoah, Joellen M Schildkraut, Ellen L Goode, Thomas A Sellers.   

Abstract

BACKGROUND: Single nucleotide polymorphisms (SNP) in microRNA-related genes have been associated with epithelial ovarian cancer (EOC) risk in two reports, yet associated alleles may be inconsistent across studies.
METHODS: We conducted a pooled analysis of previously identified SNPs by combining genotype data from 3,973 invasive EOC cases and 3,276 controls from the Ovarian Cancer Association Consortium. We also conducted imputation to obtain dense coverage of genes and comparable genotype data for all studies. In total, 226 SNPs within 15 kb of 4 miRNA biogenesis genes (DDX20, DROSHA, GEMIN4, and XPO5) and 23 SNPs located within putative miRNA binding sites of 6 genes (CAV1, COL18A1, E2F2, IL1R1, KRAS, and UGT2A3) were genotyped or imputed and analyzed in the entire dataset.
RESULTS: After adjustment for European ancestry, no overall association was observed between any of the analyzed SNPs and EOC risk.
CONCLUSIONS: Common variants in these evaluated genes do not seem to be strongly associated with EOC risk. IMPACT: This analysis suggests earlier associations between EOC risk and SNPs in these genes may have been chance findings, possibly confounded by population admixture. To more adequately evaluate the relationship between genetic variants and cancer risk, large sample sizes are needed, adjustment for population stratification should be carried out, and use of imputed SNP data should be considered. ©2011 AACR.

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Year:  2011        PMID： 21636674      PMCID： PMC3153581          DOI： 10.1158/1055-9965.EPI-11-0397

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.254


  12 in total

1.  A KRAS-variant in ovarian cancer acts as a genetic marker of cancer risk.

Authors:  Elena Ratner; Lingeng Lu; Marta Boeke; Rachel Barnett; Sunitha Nallur; Lena J Chin; Cory Pelletier; Rachel Blitzblau; Renata Tassi; Trupti Paranjape; Pei Hui; Andrew K Godwin; Herbert Yu; Harvey Risch; Thomas Rutherford; Peter Schwartz; Alessandro Santin; Ellen Matloff; Daniel Zelterman; Frank J Slack; Joanne B Weidhaas
Journal:  Cancer Res       Date:  2010-07-20       Impact factor: 12.701

2.  Principal components analysis corrects for stratification in genome-wide association studies.

Authors:  Alkes L Price; Nick J Patterson; Robert M Plenge; Michael E Weinblatt; Nancy A Shadick; David Reich
Journal:  Nat Genet       Date:  2006-07-23       Impact factor: 38.330

3.  PLINK: a tool set for whole-genome association and population-based linkage analyses.

Authors:  Shaun Purcell; Benjamin Neale; Kathe Todd-Brown; Lori Thomas; Manuel A R Ferreira; David Bender; Julian Maller; Pamela Sklar; Paul I W de Bakker; Mark J Daly; Pak C Sham
Journal:  Am J Hum Genet       Date:  2007-07-25       Impact factor: 11.025

Review 4.  Role of genetic polymorphisms in ovarian cancer susceptibility: development of an international ovarian cancer association consortium.

Authors:  Andrew Berchuck; Joellen M Schildkraut; C Leigh Pearce; Georgia Chenevix-Trench; Paul D Pharoah
Journal:  Adv Exp Med Biol       Date:  2008       Impact factor: 2.622

5.  LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer.

Authors:  Jennifer Permuth-Wey; Donghwa Kim; Ya-Yu Tsai; Hui-Yi Lin; Y Ann Chen; Jill Barnholtz-Sloan; Michael J Birrer; Gregory Bloom; Stephen J Chanock; Zhihua Chen; Daniel W Cramer; Julie M Cunningham; Getachew Dagne; Judith Ebbert-Syfrett; David Fenstermacher; Brooke L Fridley; Montserrat Garcia-Closas; Simon A Gayther; William Ge; Aleksandra Gentry-Maharaj; Jesus Gonzalez-Bosquet; Ellen L Goode; Edwin Iversen; Heather Jim; William Kong; John McLaughlin; Usha Menon; Alvaro N A Monteiro; Steven A Narod; Paul D P Pharoah; Catherine M Phelan; Xiaotao Qu; Susan J Ramus; Harvey Risch; Joellen M Schildkraut; Honglin Song; Heather Stockwell; Rebecca Sutphen; Kathryn L Terry; Jonathan Tyrer; Robert A Vierkant; Nicolas Wentzensen; Johnathan M Lancaster; Jin Q Cheng; Thomas A Sellers
Journal:  Cancer Res       Date:  2011-04-11       Impact factor: 12.701

6.  A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.

Authors:  Honglin Song; Susan J Ramus; Jonathan Tyrer; Kelly L Bolton; Aleksandra Gentry-Maharaj; Eva Wozniak; Hoda Anton-Culver; Jenny Chang-Claude; Daniel W Cramer; Richard DiCioccio; Thilo Dörk; Ellen L Goode; Marc T Goodman; Joellen M Schildkraut; Thomas Sellers; Laura Baglietto; Matthias W Beckmann; Jonathan Beesley; Jan Blaakaer; Michael E Carney; Stephen Chanock; Zhihua Chen; Julie M Cunningham; Ed Dicks; Jennifer A Doherty; Matthias Dürst; Arif B Ekici; David Fenstermacher; Brooke L Fridley; Graham Giles; Martin E Gore; Immaculata De Vivo; Peter Hillemanns; Claus Hogdall; Estrid Hogdall; Edwin S Iversen; Ian J Jacobs; Anna Jakubowska; Dong Li; Jolanta Lissowska; Jan Lubiński; Galina Lurie; Valerie McGuire; John McLaughlin; Krzysztof Medrek; Patricia G Moorman; Kirsten Moysich; Steven Narod; Catherine Phelan; Carole Pye; Harvey Risch; Ingo B Runnebaum; Gianluca Severi; Melissa Southey; Daniel O Stram; Falk C Thiel; Kathryn L Terry; Ya-Yu Tsai; Shelley S Tworoger; David J Van Den Berg; Robert A Vierkant; Shan Wang-Gohrke; Penelope M Webb; Lynne R Wilkens; Anna H Wu; Hannah Yang; Wendy Brewster; Argyrios Ziogas; Richard Houlston; Ian Tomlinson; Alice S Whittemore; Mary Anne Rossing; Bruce A J Ponder; Celeste Leigh Pearce; Roberta B Ness; Usha Menon; Susanne Krüger Kjaer; Jacek Gronwald; Montserrat Garcia-Closas; Peter A Fasching; Douglas F Easton; Georgia Chenevix-Trench; Andrew Berchuck; Paul D P Pharoah; Simon A Gayther
Journal:  Nat Genet       Date:  2009-08-02       Impact factor: 38.330

7.  The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing.

Authors:  Paul D P Pharoah; Rachel T Palmieri; Susan J Ramus; Simon A Gayther; Irene L Andrulis; Hoda Anton-Culver; Natalia Antonenkova; Antonis C Antoniou; David Goldgar; Mary S Beattie; Matthias W Beckmann; Michael J Birrer; Natalia Bogdanova; Kelly L Bolton; Wendy Brewster; Angela Brooks-Wilson; Robert Brown; Ralf Butzow; Trinidad Caldes; Maria Adelaide Caligo; Ian Campbell; Jenny Chang-Claude; Y Ann Chen; Linda S Cook; Fergus J Couch; Daniel W Cramer; Julie M Cunningham; Evelyn Despierre; Jennifer A Doherty; Thilo Dörk; Matthias Dürst; Diana M Eccles; Arif B Ekici; Douglas Easton; Peter A Fasching; Anna de Fazio; David A Fenstermacher; James M Flanagan; Brooke L Fridley; Eitan Friedman; Bo Gao; Olga Sinilnikova; Aleksandra Gentry-Maharaj; Andrew K Godwin; Ellen L Goode; Marc T Goodman; Jenny Gross; Thomas V O Hansen; Paul Harnett; Matti Rookus; Tuomas Heikkinen; Rebecca Hein; Claus Høgdall; Estrid Høgdall; Edwin S Iversen; Anna Jakubowska; Sharon E Johnatty; Beth Y Karlan; Noah D Kauff; Stanley B Kaye; Georgia Chenevix-Trench; Linda E Kelemen; Lambertus A Kiemeney; Susanne Krüger Kjaer; Diether Lambrechts; James P Lapolla; Conxi Lázaro; Nhu D Le; Arto Leminen; Karin Leunen; Douglas A Levine; Yi Lu; Lene Lundvall; Stuart Macgregor; Tamara Marees; Leon F Massuger; John R McLaughlin; Usha Menon; Marco Montagna; Kirsten B Moysich; Steven A Narod; Katherine L Nathanson; Lotte Nedergaard; Roberta B Ness; Heli Nevanlinna; Stefan Nickels; Ana Osorio; Jim Paul; Celeste Leigh Pearce; Catherine M Phelan; Malcolm C Pike; Paolo Radice; Mary Anne Rossing; Joellen M Schildkraut; Thomas A Sellers; Christian F Singer; Honglin Song; Daniel O Stram; Rebecca Sutphen; Annika Lindblom; Kathryn L Terry; Ya-Yu Tsai; Anne M van Altena; Ignace Vergote; Robert A Vierkant; Allison F Vitonis; Christine Walsh; Shan Wang-Gohrke; Barbara Wappenschmidt; Anna H Wu; Argyrios Ziogas; Andrew Berchuck; Harvey A Risch
Journal:  Clin Cancer Res       Date:  2011-03-08       Impact factor: 12.531

8.  PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits.

Authors:  Lei Bao; Mi Zhou; Ligang Wu; Lu Lu; Dan Goldowitz; Robert W Williams; Yan Cui
Journal:  Nucleic Acids Res       Date:  2006-11-11       Impact factor: 16.971

Review 9.  The role of microRNAs in ovarian cancer initiation and progression.

Authors:  Shuang-Di Li; Jia-Rong Zhang; Yan-Qiu Wang; Xiao-Ping Wan
Journal:  J Cell Mol Med       Date:  2010-09       Impact factor: 5.310

10.  SNPinfo: integrating GWAS and candidate gene information into functional SNP selection for genetic association studies.

Authors:  Zongli Xu; Jack A Taylor
Journal:  Nucleic Acids Res       Date:  2009-05-05       Impact factor: 16.971
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  9 in total

1.  Common genetic variants in the microRNA biogenesis pathway are not associated with breast cancer risk in Asian women.

Authors:  Hyuna Sung; Ben Zhang; Ji-Yeob Choi; Jirong Long; Sue K Park; Keun-Young Yoo; Dong-Young Noh; Sei-Hyun Ahn; Wei Zheng; Daehee Kang
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2012-06-19       Impact factor: 4.254

2.  Common variation in Nemo-like kinase is associated with risk of ovarian cancer.

Authors:  Kristen N Stevens; Linda E Kelemen; Xianshu Wang; Brooke L Fridley; Robert A Vierkant; Zachary Fredericksen; Sebastian M Armasu; Ya-Yu Tsai; Andrew Berchuck; Steven A Narod; Catherine M Phelan; Rebecca Sutphen; Michael J Birrer; Joellen M Schildkraut; Thomas A Sellers; Ellen L Goode; Fergus J Couch
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2012-01-17       Impact factor: 4.254

Review 3.  The role of MicroRNA molecules and MicroRNA-regulating machinery in the pathogenesis and progression of epithelial ovarian cancer.

Authors:  Xiyin Wang; Mircea Ivan; Shannon M Hawkins
Journal:  Gynecol Oncol       Date:  2017-08-31       Impact factor: 5.482

4.  Serum endostatin is a genetically determined predictor of survival in pulmonary arterial hypertension.

Authors:  Rachel Damico; Todd M Kolb; Lidenys Valera; Lan Wang; Traci Housten; Ryan J Tedford; David A Kass; Nicholas Rafaels; Li Gao; Kathleen C Barnes; Raymond L Benza; James L Rand; Rizwan Hamid; James E Loyd; Ivan M Robbins; Anna R Hemnes; Wendy K Chung; Eric D Austin; M Bradley Drummond; Stephen C Mathai; Paul M Hassoun
Journal:  Am J Respir Crit Care Med       Date:  2015-01-15       Impact factor: 21.405

5.  A 3' UTR SNP in COL18A1 is associated with susceptibility to HBV related hepatocellular carcinoma in Chinese: three independent case-control studies.

Authors:  Xiaopan Wu; Jia Wu; Zhenhui Xin; Huifen Wang; Xilin Zhu; Liping Pan; Zhuo Li; Hui Li; Ying Liu
Journal:  PLoS One       Date:  2012-03-26       Impact factor: 3.240

6.  A functional variant in HOXA11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer.

Authors:  Edward J Richards; Jennifer Permuth-Wey; Yajuan Li; Y Ann Chen; Domenico Coppola; Brett M Reid; Hui-Yi Lin; Jamie K Teer; Andrew Berchuck; Michael J Birrer; Kate Lawrenson; Alvaro N A Monteiro; Joellen M Schildkraut; Ellen L Goode; Simon A Gayther; Thomas A Sellers; Jin Q Cheng
Journal:  Oncotarget       Date:  2015-10-27

Review 7.  Exosomal MicroRNAs Mediating Crosstalk Between Cancer Cells With Cancer-Associated Fibroblasts and Tumor-Associated Macrophages in the Tumor Microenvironment.

Authors:  Tong Su; Panpan Zhang; Fujun Zhao; Shu Zhang
Journal:  Front Oncol       Date:  2021-04-01       Impact factor: 6.244

Review 8.  The role of microRNAs in cancer susceptibility.

Authors:  Rodolfo Iuliano; Marco Flavio Michele Vismara; Vincenzo Dattilo; Francesco Trapasso; Francesco Baudi; Nicola Perrotti
Journal:  Biomed Res Int       Date:  2013-03-19       Impact factor: 3.411

9.  Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31.

Authors:  Jennifer Permuth-Wey; Kate Lawrenson; Howard C Shen; Aneliya Velkova; Jonathan P Tyrer; Zhihua Chen; Hui-Yi Lin; Y Ann Chen; Ya-Yu Tsai; Xiaotao Qu; Susan J Ramus; Rod Karevan; Janet Lee; Nathan Lee; Melissa C Larson; Katja K Aben; Hoda Anton-Culver; Natalia Antonenkova; Antonis C Antoniou; Sebastian M Armasu; François Bacot; Laura Baglietto; Elisa V Bandera; Jill Barnholtz-Sloan; Matthias W Beckmann; Michael J Birrer; Greg Bloom; Natalia Bogdanova; Louise A Brinton; Angela Brooks-Wilson; Robert Brown; Ralf Butzow; Qiuyin Cai; Ian Campbell; Jenny Chang-Claude; Stephen Chanock; Georgia Chenevix-Trench; Jin Q Cheng; Mine S Cicek; Gerhard A Coetzee; Linda S Cook; Fergus J Couch; Daniel W Cramer; Julie M Cunningham; Agnieszka Dansonka-Mieszkowska; Evelyn Despierre; Jennifer A Doherty; Thilo Dörk; Andreas du Bois; Matthias Dürst; Douglas F Easton; Diana Eccles; Robert Edwards; Arif B Ekici; Peter A Fasching; David A Fenstermacher; James M Flanagan; Montserrat Garcia-Closas; Aleksandra Gentry-Maharaj; Graham G Giles; Rosalind M Glasspool; Jesus Gonzalez-Bosquet; Marc T Goodman; Martin Gore; Bohdan Górski; Jacek Gronwald; Per Hall; Mari K Halle; Philipp Harter; Florian Heitz; Peter Hillemanns; Maureen Hoatlin; Claus K Høgdall; Estrid Høgdall; Satoyo Hosono; Anna Jakubowska; Allan Jensen; Heather Jim; Kimberly R Kalli; Beth Y Karlan; Stanley B Kaye; Linda E Kelemen; Lambertus A Kiemeney; Fumitaka Kikkawa; Gottfried E Konecny; Camilla Krakstad; Susanne Krüger Kjaer; Jolanta Kupryjanczyk; Diether Lambrechts; Sandrina Lambrechts; Johnathan M Lancaster; Nhu D Le; Arto Leminen; Douglas A Levine; Dong Liang; Boon Kiong Lim; Jie Lin; Jolanta Lissowska; Karen H Lu; Jan Lubiński; Galina Lurie; Leon F A G Massuger; Keitaro Matsuo; Valerie McGuire; John R McLaughlin; Usha Menon; Francesmary Modugno; Kirsten B Moysich; Toru Nakanishi; Steven A Narod; Lotte Nedergaard; Roberta B Ness; Heli Nevanlinna; Stefan Nickels; Houtan Noushmehr; Kunle Odunsi; Sara H Olson; Irene Orlow; James Paul; Celeste L Pearce; Tanja Pejovic; Liisa M Pelttari; Malcolm C Pike; Elizabeth M Poole; Paola Raska; Stefan P Renner; Harvey A Risch; Lorna Rodriguez-Rodriguez; Mary Anne Rossing; Anja Rudolph; Ingo B Runnebaum; Iwona K Rzepecka; Helga B Salvesen; Ira Schwaab; Gianluca Severi; Viji Shridhar; Xiao-Ou Shu; Yurii B Shvetsov; Weiva Sieh; Honglin Song; Melissa C Southey; Beata Spiewankiewicz; Daniel Stram; Rebecca Sutphen; Soo-Hwang Teo; Kathryn L Terry; Daniel C Tessier; Pamela J Thompson; Shelley S Tworoger; Anne M van Altena; Ignace Vergote; Robert A Vierkant; Daniel Vincent; Allison F Vitonis; Shan Wang-Gohrke; Rachel Palmieri Weber; Nicolas Wentzensen; Alice S Whittemore; Elisabeth Wik; Lynne R Wilkens; Boris Winterhoff; Yin Ling Woo; Anna H Wu; Yong-Bing Xiang; Hannah P Yang; Wei Zheng; Argyrios Ziogas; Famida Zulkifli; Catherine M Phelan; Edwin Iversen; Joellen M Schildkraut; Andrew Berchuck; Brooke L Fridley; Ellen L Goode; Paul D P Pharoah; Alvaro N A Monteiro; Thomas A Sellers; Simon A Gayther
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919
  9 in total

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