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Literature DB >> 22713968

Circulating microRNAs as novel and sensitive biomarkers of acute myocardial Infarction.

Chuanwei Li¹, Fang Pei, Xiaoshan Zhu, Dayue D Duan, Chunyu Zeng.

Abstract

Coronary artery disease and acute myocardial infarction (AMI) are the leading causes of death for both men and women. Serum cardiac-specific troponin level is now used for the "early" diagnosis of AMI. However, due to the "delayed" release of troponin, an earlier, more sensitive and specific biomarker is urgently demanded to further reduce AMI mortality. Recent studies have found that circulating microRNAs (miRNAs) are closely linked to myocardial injury. Due to the cell-specific physiological functions and the stability of miRNAs in plasma, serum, and urine, they are emerging as sensitive biomarkers of AMI. This review summarizes the latest insights into the identification and potential application of plasma and serum miRNAs as novel biomarkers for diagnosis and prognosis of AMI.

Entities: CellLine Chemical Disease Gene Species

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Year: 2012 PMID： 22713968 PMCID： PMC3965350 DOI： 10.1016/j.clinbiochem.2012.04.013

Source DB: PubMed Journal: Clin Biochem ISSN： 0009-9120 Impact factor: 3.281

75 in total

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Authors: J Ratajczak; M Wysoczynski; F Hayek; A Janowska-Wieczorek; M Z Ratajczak
Journal: Leukemia Date: 2006-07-20 Impact factor: 11.528

2. The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes.

Authors: Chaoqian Xu; Yanjie Lu; Zhenwei Pan; Wenfeng Chu; Xiaobin Luo; Huixian Lin; Jiening Xiao; Hongli Shan; Zhiguo Wang; Baofeng Yang
Journal: J Cell Sci Date: 2007-09-01 Impact factor: 5.285

3. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond.

Authors: Michael J Pencina; Ralph B D'Agostino; Ralph B D'Agostino; Ramachandran S Vasan
Journal: Stat Med Date: 2008-01-30 Impact factor: 2.373

4. Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.

Authors: Jean-Pierre Bassand; Christian W Hamm; Diego Ardissino; Eric Boersma; Andrzej Budaj; Francisco Fernández-Avilés; Keith A A Fox; David Hasdai; E Magnus Ohman; Lars Wallentin; William Wijns
Journal: Eur Heart J Date: 2007-06-14 Impact factor: 29.983

Circulating microRNAs as novel and sensitive biomarkers of acute myocardial Infarction.

Review 1. Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication.

2. The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes.

3. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond.

4. Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.

5. Control of stress-dependent cardiac growth and gene expression by a microRNA.

6. The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2.

7. ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation.

8. Major causes of death among men and women in China.

9. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.

10. miRBase: tools for microRNA genomics.

Review 1. Role of microRNAs in the trabecular meshwork.

2. Serum Exosomes Attenuate H₂O₂-Induced Apoptosis in Rat H9C2 Cardiomyocytes via ERK1/2.

3. Plasma Exosomal miR-450b-5p as a Possible Biomarker and Therapeutic Target for Transient Ischaemic Attacks in Rats.

Review 4. microRNA-based diagnostics and therapy in cardiovascular disease-Summing up the facts.

Review 5. Far-infrared therapy for cardiovascular, autoimmune, and other chronic health problems: A systematic review.

Review 6. Differential expression of microRNAs in ischemic heart disease.

Review 7. Circulating microRNAs as novel biomarkers for the early diagnosis of acute coronary syndrome.

8. Circulating microRNAs and sudden cardiac arrest outcomes.

9. Circulating microRNAs as Novel Biomarkers for Atherosclerosis.

10. Extracellular MicroRNAs Induce Potent Innate Immune Responses via TLR7/MyD88-Dependent Mechanisms.