| Literature DB >> 25461956 |
Minwoo A Song1, Alexandra N Paradis1, Maresha S Gay1, John Shin1, Lubo Zhang2.
Abstract
Recent studies provide evidence that ischemic preconditioning (IP) and ischemia/reperfusion (IR) injury lead to altered expression of microRNAs (miRNAs) that affect the survival and recovery of cardiomyocytes. These endogenous ∼22-nucleotide noncoding RNAs negatively regulate gene expression via degradation and translational inhibition of their target mRNAs. miRNAs are involved in differentiation, proliferation, electrical conduction, angiogenesis and apoptosis. These pathways can lead to physiological and pathological adaptations. This review intends to explore several facets of miRNA expression and the underlying mechanisms involved in IR injury, as well as IP as a cardioprotective strategy. In addition, we will investigate miRNA interaction with the renin-angiotensin system and the potential use of miRNAs in developing sensitive biomarkers for cardiovascular disease.Entities:
Mesh：
Substances：
Year: 2014 PMID： 25461956 PMCID： PMC4336590 DOI： 10.1016/j.drudis.2014.10.004
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851