Seda Gulec Yilmaz1, Selim Isbir2, Atike Tekeli Kunt3, Turgay Isbir4. 1. Department of Molecular Medicine, Institute of Health Sciences, Faculty of Medicine, Yeditepe University, Istanbul, Turkey seda0802@yahoo.com. 2. Department of Cardiovascular Surgery, Marmara University Pendik Education and Research Hospital, Istanbul, Turkey. 3. Department of Cardiovascular Surgery, Ankara Numune Education and Research Hospital, Ankara, Turkey. 4. Department of Medical Biology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey.
Abstract
BACKGROUND/AIM: In this study, we determined the expression of selected circulating microRNAs (miRNA) and their potential roles as biomarkers in patients with atherosclerosis and a control group. MATERIALS AND METHODS: In order to obtain insight into miRNA expression levels in atherosclerosis, we analyzed miRNA expression levels by real-time polymerase chain reaction (RT-PCR) in case (n=89) and healthy control (n=93) groups. Receiver operating characteristic curve analysis was performed to assess the diagnostic capability of miRNAs. RESULTS: miRNA221 and miRNA221 expression levels were significantly lower in patients than controls (p=0.011 and p=0.004, respectively). Receiver operator curve analysis demonstrated that expression levels of miRNA221 [area under curve (AUC)=0.623, p=0.0086) and miRNA222 (AUC=0.654, p=0.0006) were significantly different between groups. There were positive correlations between miRNA122a and triglyceride (p=0.046) and very-low-density lipoprotein (p=0.029) levels. CONCLUSION: miRNA221 and miRNA222 could be convenient biomarkers for diagnosis of atherosclerosis. Copyright
BACKGROUND/AIM: In this study, we determined the expression of selected circulating microRNAs (miRNA) and their potential roles as biomarkers in patients with atherosclerosis and a control group. MATERIALS AND METHODS: In order to obtain insight into miRNA expression levels in atherosclerosis, we analyzed miRNA expression levels by real-time polymerase chain reaction (RT-PCR) in case (n=89) and healthy control (n=93) groups. Receiver operating characteristic curve analysis was performed to assess the diagnostic capability of miRNAs. RESULTS:miRNA221 and miRNA221 expression levels were significantly lower in patients than controls (p=0.011 and p=0.004, respectively). Receiver operator curve analysis demonstrated that expression levels of miRNA221 [area under curve (AUC)=0.623, p=0.0086) and miRNA222 (AUC=0.654, p=0.0006) were significantly different between groups. There were positive correlations between miRNA122a and triglyceride (p=0.046) and very-low-density lipoprotein (p=0.029) levels. CONCLUSION:miRNA221 and miRNA222 could be convenient biomarkers for diagnosis of atherosclerosis. Copyright
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